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Engineering Graded Tissue Interfaces

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Structural Interfaces and Attachments in Biology

Abstract

Native tissue interfaces show transitions in cell type, structure, composition, and organization of extracellular matrix, chemical signals, mineralization, mechanical properties, and biological function. In this chapter, we discuss engineering of tissue interfaces, with an emphasis on scaffold design. An ideal scaffold should be able to accommodate transitions in tissue elements in order to transmit the properties of one tissue to another. Regenerative medicine strategies for synthesizing tissue interfaces are reviewed, including the generation of continuous physical and chemical gradients for the formation of strong attachments. We highlight the importance of the scaffold for directing cellular behavior to form an interface similar to native tissue.

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Authors and Affiliations

  1. Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS, USA

    Neethu Mohan & Michael Detamore

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  1. Neethu Mohan
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  2. Michael Detamore
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Correspondence to Michael Detamore .

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Editors and Affiliations

  1. , Department of Orthopedic Surgery, Washington University, South Euclid 660, St. Louis, 63110, Missouri, USA

    Stavros Thomopoulos

  2. , Engineering Education Center, Missouri University of Science and Tech., University Blvd. One, St. Louis, 63121, Missouri, USA

    Victor Birman

  3. , Mechanical Engineering, Washington University, 1 Brookings Drive, St. Louis, 63130, Missouri, USA

    Guy M. Genin

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Mohan, N., Detamore, M. (2013). Engineering Graded Tissue Interfaces. In: Thomopoulos, S., Birman, V., Genin, G. (eds) Structural Interfaces and Attachments in Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3317-0_14

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