Chances are the major professor has a clear idea of what a student project will be and what methods to use. It may involve the operation of an important piece of laboratory equipment in the lab. Sometimes, however, projects take a turn requiring development of a specific method to provide specific data. This chapter will cover some of the things to consider when developing methodology. First let us review the two previous unit operations—Problem definition (Chap. 3) and critical evaluation of the literature (Chap. 4).