NIRS: Theoretical Background and Practical Aspects

Chapter

Abstract

In this chapter, an introduction to near-infrared spectroscopy (NIRS) as a tool for brain functional monitoring and imaging is presented. The basic physical principles are outlined for the measurement of physiological parameters like cortical haemoglobin oxygenation and blood flow. The advantages of spatially resolved as well as time- and frequency-domain techniques are discussed and compared with the modified Lambert–Beer approach which is used in most topographic imaging systems.

References

  1. Alerstam E, Svensson T, Andersson-Engels S (2008) Parallel computing with graphics processing units for high speed Monte Carlo simulation of photon migration. J Biomed Opt 13:060504CrossRefGoogle Scholar
  2. Arridge SR (1999) Optical tomography in medical imaging. Inverse Probl 5:41–93CrossRefGoogle Scholar
  3. Arridge S, Cope M, Delpy DT (1992) The theoretical basis for the determination of optical pathlengths in tissue: temporal and frequency analysis. Phys Med Biol 37:1531–1560PubMedCrossRefGoogle Scholar
  4. Atsumori H, Kiguchi M, Katura T, Funane T, Obata A, Sato H, Manaka T, Iwamoto M, Maki A, Koizumi H, Kubota K (2010) Noninvasive imaging of prefrontal activation during attention-demanding tasks performed while walking using a wearable optical topography system. J Biomed Opt 15:046002PubMedCrossRefGoogle Scholar
  5. Boas DA, Chen K, Grebert D, Franceschini MA (2004) Improving the diffuse optical imaging spatial resolution of the cerebral hemodynamic response to brain activation in humans. Opt Lett 29:506–1508CrossRefGoogle Scholar
  6. Boden S, Obrig H, Kohncke C, Benav H, Koch SP, Steinbrink J (2007) The oxygenation response to functional stimulation: is there a physiological meaning to the lag between parameters? Neuroimage 36:100–107PubMedCrossRefGoogle Scholar
  7. Bonner R, Nossal R (1981) Model for laser Doppler measurements of blood flow in tissue. Appl Opt 20:2097–2107PubMedCrossRefGoogle Scholar
  8. Briers JD (2001) Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging. Physiol Meas 22:R35–R66PubMedCrossRefGoogle Scholar
  9. Chance B, Nioka S, Kent J, McCully K, Fountain M, Greenfeld R, Holtom G (1988) Time resolved spectroscopy of hemoglobin and myoglobin in resting and ischemic muscle. Anal Biochem 174:698–707PubMedCrossRefGoogle Scholar
  10. Chance B, Zhuang Z, UnAh C, Alter C, Lipton L (1993) Cognition-activated low-frequency modulation of light absorption in human brain. Proc Natl Acad Sci USA 90:3770–3774PubMedCrossRefGoogle Scholar
  11. Chance B, Cope M, Gratton E, Ramanujam N, Tromberg B (1998) Phase measurement of light absorption and scatter in human tissues. Rev Sci Instrum 69:3457–3481CrossRefGoogle Scholar
  12. Cohen LB, Keynes RD, Hille B (1968) Light scattering and birefringence changes during nerve activity. Nature 218:438–441PubMedCrossRefGoogle Scholar
  13. Cooper CE, Springett R (1997) Measurement of cytochrome oxidase and mitochondrial energetics by nearinfrared spectroscopy. Philos Trans R Lond B Biol Sci 352(1354):669–676CrossRefGoogle Scholar
  14. Delpy DT, Cope M (1997) Quantification in tissue near-infrared spectroscopy. Philos Trans R Soc Lond B Biol Sci 352(1354):649–659CrossRefGoogle Scholar
  15. Delpy DT, Cope M, van der Zee P, Arridge SR, Wray S, Wyatt JS (1988) Estimation of optical pathlength through tissue from direct time of flight measurements. Phys Med Biol 33:1433–1442PubMedCrossRefGoogle Scholar
  16. Dunn AK, Devor A, Dale AM, Boas DA (2005) Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex. Neuroimage 27:279–290PubMedCrossRefGoogle Scholar
  17. Durduran T, Yu G, Burnett MG, Detre JA, Greenberg JH, Wang J, Zhou C, Yodh AG (2004) Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation. Opt Lett 29:1766–1768PubMedCrossRefGoogle Scholar
  18. Essenpreis M, Elwell CE, Cope M, van der Zee P, Arridge SR, Delpy DT (1993) Spectral dependence of temporal point spread functions in human tissues. Appl Opt 32:418–425PubMedCrossRefGoogle Scholar
  19. Fantini S, Franceschini MA, Fishkin JB, Barbieri B, Gratton E (1994) Quantitative determination of the absorption spectra of chromophores in strongly scattering media: a light emitting diode based technique. Appl Opt 33:5204–5213PubMedCrossRefGoogle Scholar
  20. Fishkin JB, So PT, Cerussi AE, Fantini S, Franceschini MA, Gratton E (1995) Frequency-domain method for measuring spectral properties in multiple-scattering media: methemoglobin absorption spectrum in a tissue like phantom. Appl Opt 34:1143–1155PubMedCrossRefGoogle Scholar
  21. Franceschini MA, Fantini S, Thompson JH, Culver JP, Boas DA (2003) Hemodynamic evoked response of the sensorimotor cortex measured non-invasively with near-infrared optical imaging. Psychophysiology 40:548–560PubMedCrossRefGoogle Scholar
  22. Gora F, Shinde S, Elwell CE, Goldstone JC, Cope M, Delpy DT, Smith M (2002) Measurement of cerebral blood flow in adults using near infrared spectroscopy and indocyanine green. J Neurosurg Anesthesiol 14:218–222PubMedCrossRefGoogle Scholar
  23. Gratton G, Brumback CR, Gordon BA, Pearson MA, Low KA, Fabiani M (2006) Effects of measurement method, wavelength, and source-detector distance on the fast optical signal. Neuroimage 32:1576–1590PubMedCrossRefGoogle Scholar
  24. Hebden JC, Gibson A, Yusof R, Everdell N, Hillman E, Delpy DT, Arridge S, Austin T, Meek J, Wyatt J (2002) Three-dimensional optical tomography of the premature infant brain. Phys Med Biol 47:4155–4166PubMedCrossRefGoogle Scholar
  25. Hillman EM (2007) Optical brain imaging in vivo: techniques and applications from animal to man. J Biomed Opt 12:051402PubMedCrossRefGoogle Scholar
  26. Hoshi Y (2003) Functional near-infrared optical imaging: utility and limitations in human brain mapping. Psychophysiology 40:511–520PubMedCrossRefGoogle Scholar
  27. Hoshi Y, Tamura M (1993) Dynamic multichannel near-infrared optical imaging of human brain activity. J Appl Physiol 75:1842–1846PubMedGoogle Scholar
  28. Jobsis F (1977) Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198:1264–1267PubMedCrossRefGoogle Scholar
  29. Kato T, Kamei A, Takashima S, Ozaki T (1993) Human visual cortical function during photic stimulation monitoring by means of near-infrared spectroscopy. J Cereb Blood Flow Metab 13:516–520PubMedCrossRefGoogle Scholar
  30. Kawaguchi H, Hayashi T, Kato T, Okada E (2004) Theoretical evaluation of accuracy in position and size of brain activity obtained by near-infrared topography. Phys Med Biol 49:2753–2765PubMedCrossRefGoogle Scholar
  31. Kohl M, Watson R, Cope M (1997) Optical properties of highly scattering media from changes in attenuation and phase and modulation depths. Appl Opt 36:105–115PubMedCrossRefGoogle Scholar
  32. Koizumi H, Yamamoto T, Maki A, Yamashita Y, Sato H, Kawaguchi H, Ichikawa N (2003) Optical topography: practical problems and new applications. Appl Opt 42:3054–3062PubMedCrossRefGoogle Scholar
  33. Kuebler WM, Sckell A, Habler O, Kleen M, Kuhnle GEH, Welte M, Messmer K, Goetz AE (1998) Noninvasive measurement of regional cerebral blood flow by near-infrared spectroscopy and indocyanine green. J Cereb Blood Flow Metab 18:445–456PubMedCrossRefGoogle Scholar
  34. Li J, Dietsche G, Iftime D, Skipetrov SE, Maret G, Elbert T, Rockstroh B, Gisler T (2005) Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy. J Biomed Opt 10:44002CrossRefGoogle Scholar
  35. Liebert A, Wabnitz H, Steinbrink J, Obrig H, Möller M, MacDonald R, Villringer A, Rinneberg H (2004) Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons. Appl Opt 43:3037–3047PubMedCrossRefGoogle Scholar
  36. Liebert A, Wabnitz H, Steinbrink J, Moller M, Macdonald R, Rinneberg H, Villringer A, Obrig H (2005) Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance. Neuroimage 24:426–435PubMedCrossRefGoogle Scholar
  37. Liebert A, Wabnitz H, Obrig H, Erdmann R, Möller M, Macdonald R, Rinneberg H, Villringer A, Steinbrink J (2006) Non-invasive detection of fluorescence from exogenous chromophores in the adult human brain. Neuroimage 31:600–608PubMedCrossRefGoogle Scholar
  38. Madsen PL, Secher NH (1999) Near-infrared oximetry of the brain. Prog Neurobiol 58:541–560PubMedCrossRefGoogle Scholar
  39. Matcher SJ, Cope M, Delpy DT (1993) Use of the water absorption spectrum to quantify tissue chromophore concentration changes in near-infrared spectroscopy. Phys Med Biol 38:177–196Google Scholar
  40. Matcher SJ, Kirkpatrick P, Nahid K, Cope M, Delpy DT (1995) Absolute quantification methods in tissue near infrared spectroscopy. Proc SPIE 2389:486–495CrossRefGoogle Scholar
  41. Matcher SJ, Cope M, Delpy DT (1997) In vivo measurements of the wavelength dependence of tissue scattering coefficients between 760 and 900 nm measured with time resolved spectroscopy. Appl Opt 36:386–396PubMedCrossRefGoogle Scholar
  42. McGown AD, Makker H, Elwell C, Rawi PGA, Valipour A, Spiro SG (2003) Measurement of changes in cytochrome oxidase redox state during obstructive sleep apnea using near-infrared spectroscopy. Sleep 26:1–7Google Scholar
  43. Miyai I, Tanabe HC, Sase I, Eda H, Oda I, Konishi I, Tsunazawa Y, Suzuki T, Yanagida T, Kubota K (2001) Cortical mapping of gait in humans: a near-infrared spectroscopic topography study. Neuroimage 14:1186–1192PubMedCrossRefGoogle Scholar
  44. Obrig H, Villringer A (2003) Beyond the visible – imaging the human brain with light. J Cereb Blood Flow Metab 23:1–18PubMedCrossRefGoogle Scholar
  45. Obrig H, Neufang M, Wenzel R, Kohl M, Steinbrink J, Einhaupl K, Villringer A (2000) Spontaneous low frequency oscillations of cerebral hemodynamics and metabolism in human adults. Neuroimage 12:623–639PubMedCrossRefGoogle Scholar
  46. Okada E, Firbank M, Schweiger M, Arridge SR, Cope M, Delpy DT (1997) Theoretical and experimental investigation of near-infrared light propagation in a model of the adult head. Appl Opt 36:21–31PubMedCrossRefGoogle Scholar
  47. Patterson MS, Chance B, Wilson BC (1989) Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. Appl Opt 28:2331–2336PubMedCrossRefGoogle Scholar
  48. Patterson MS, Moulton JD, Wilson BC, Berndt KW, Lakowicz JR (1991) Frequency-domain reflectance for the determination of the scattering and absorption properties of tissue. Appl Opt 30:4474–4476PubMedCrossRefGoogle Scholar
  49. Pogue BW, Patterson MS (1994) Frequency-domain optical absorption spectroscopy of finite tissue volumes using diffusion theory. Phys Med Biol 39:1157–1180PubMedCrossRefGoogle Scholar
  50. Prahl S (2001) Optical properties spectra. http://omlc.ogi.edu/spectra
  51. Rector DM, Carter KM, Volegov PL, George JS (2005) Spatio-temporal mapping of rat whisker barrels with fast scattered light signals. Neuroimage 26:619–627PubMedCrossRefGoogle Scholar
  52. Schmidt FEW, Fry ME, Hillman EMC, Hebden JC, Delpy DT (2000) A 32-channel time-resolved instrument for medical optical tomography. Rev Sci Instrum 71:256–265CrossRefGoogle Scholar
  53. Schmitz Ch, Löcker M, Lasker J, Hielsher AH, Barbour RL (2002) Instrumentation for fast functional optical tomography. Rev Sci Instrum 73:429–439CrossRefGoogle Scholar
  54. Steinbrink J, Wabnitz H, Obrig H, Villringer A, Rinneberg H (2001) Determining changes in NIR absorption using a layered model of the human head. Phys Med Biol 46:879–896PubMedCrossRefGoogle Scholar
  55. Steinbrink J, Kempf FC, Villringer A, Obrig H (2005) The fast optical signal – robust or elusive when noninvasively measured in the human adult? Neuroimage 26:996–1008PubMedCrossRefGoogle Scholar
  56. Suzuki S, Takasaki S, Ozaki T, Kobayashi Y (1999) A tissue Oxygenation monitor using NIR spatially resolved spectroscopy. Proc SPIE 3597:582–592CrossRefGoogle Scholar
  57. Suzuki M, Miyai I, Ono T, Kubota K (2008) Activities in the frontal cortex and gait performance are modulated by preparation. An fNIRS study. Neuroimage 39:600–607PubMedCrossRefGoogle Scholar
  58. Torricelli A, Pifferi A, Taroni P, Giambattistelli E, Cubeddu R (2001) In vivo optical characterization of human tissues from 610 to 1010 nm by time-resolved reflectance Spectroscopy. Phys Med Biol 46:2227–2237PubMedCrossRefGoogle Scholar
  59. Tromberg BJ, Svaasand LO, Tsay T-T, Haskell RC (1993) Properties of photon density waves in multiple-scattering media. Appl Opt 32:607–616PubMedCrossRefGoogle Scholar
  60. Villringer A, Chance B (1997) Non-invasive optical spectroscopy and imaging of human brain function. Trends Neurosci 20:435–442PubMedCrossRefGoogle Scholar
  61. Villringer A, Planck J, Hock C, Schleinkofer L, Dirnagl U (1993) Near infrared spectroscopy (NIRS): a new tool to study hemodynamic changes during activation of brain function in human adults. Neurosci Lett 154:101–104PubMedCrossRefGoogle Scholar
  62. Wang L-H, Jacques SL, Zheng L-Q (1995) MCML – Monte Carlo modeling of photon transport in multi-layered tissues. Comput Methods Prog Biomed 47:131–146CrossRefGoogle Scholar
  63. Wolf M, Ferrari M, Quaresima V (2007) Progress of near-infrared spectroscopy and topography for brain and muscle clinical applications. J Biomed Opt 12(062104):1–14Google Scholar
  64. Wray S, Cope M, Delpy DT, Wyatt JS, Reynolds EO (1988) Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation. Biochim Biophys Acta 933:184–192PubMedCrossRefGoogle Scholar
  65. Yamashita Y, Maki A, Koizumi H (1996) Near-infra-red topographic measurement system: imaging of absorbers localized in a scattering medium. Rev Sci Instrum 67:730–732CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.RheinAhrCampusUniversity of Applied Sciences KoblenzRemagenGermany

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