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Retinal Degenerative Diseases pp 199–205Cite as

The Role of Monocytes and Macrophages in Age-Related Macular Degeneration

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 801))

Abstract

White blood cells, particularly monocytes and their descendants, macrophages, have been implicated in age-related macular degeneration (AMD) pathology. In this minireview, we describe the current knowledge of monocyte and macrophage involvement in AMD. Chemokine receptors present on these cells such as CCR1, CCR2, and CX3CR1, and their roles in monocyte/macrophage recruitment to sites of injury and inflammation in the context of AMD will be reviewed. Mice models for perturbation of chemokine receptors that recapitulate some of the features of AMD are also described. The body of evidence from human and rodent studies at this point in time suggests that monocyte and macrophages may modulate the course of AMD.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Hadassah-Hebrew University Medical Center, 91120, Jerusalem, Israel

    Michelle Grunin, Shira Hagbi-Levi & Itay Chowers

Authors
  1. Michelle Grunin
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  2. Shira Hagbi-Levi
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  3. Itay Chowers
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Corresponding author

Correspondence to Itay Chowers .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, University of Florida, Gainesville, Florida, USA

    John D. Ash

  2. University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

  3. Cole Eye Institute at the Cleveland Clin Division of Ophthalmology, Cleveland, Ohio, USA

    Joe G. Hollyfield

  4. Dean A. McGee Eye Inst., University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  5. Beckman Vision Center, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Matthew M. LaVail

  6. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

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Grunin, M., Hagbi-Levi, S., Chowers, I. (2014). The Role of Monocytes and Macrophages in Age-Related Macular Degeneration. In: Ash, J., Grimm, C., Hollyfield, J., Anderson, R., LaVail, M., Bowes Rickman, C. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 801. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3209-8_26

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  • DOI: https://doi.org/10.1007/978-1-4614-3209-8_26

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-3208-1

  • Online ISBN: 978-1-4614-3209-8

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