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New Techniques for Optical and Molecular Visualization of Lung Cancer

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Molecular Pathology of Lung Cancer

Part of the book series: Molecular Pathology Library ((MPLB,volume 6))

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Abstract

Current imaging techniques do not allow visualization of the histology of pulmonary lesions prior to biopsy and, thus, sampling errors may lead to incorrect diagnoses, optimal areas of a tumor may not be sampled for diagnosis and heterogeneous patterns within a single cancer having an impact on treatment may not be sampled. Several imaging modalities are under investigation to provide real-time in vivo histologic images with subcellular resolution, equivalent to traditional histologic sections, and potential identification of molecular targets in vivo, greatly enhancing biopsy procurement and possibly replacing traditional biopsy with “optical biopsy” in the future. Potential benefits of these investigational techniques include avoiding sampling errors that necessitate repeat biopsies, significantly shortening the time for diagnosis and treatment of lung cancers, permit sampling of differing histologic patterns within a single lung cancer which may expand options for biomarker testing and therapy selection, and permit diagnosis of earlier cancers which is likely to improve outcome. These new techniques would be able to visualize specific receptors or other molecular targets on neoplastic cells in vivo using tagged ligands or probes specific to the receptor or other target. The identification of specific molecular targets in vivo could enhance time to treatment. These modalities include optical coherence tomography, endoscopic confocal microscopy, and coherent anti-Stokes Raman scattering microscopy. Image-guided multimodality theranostic systems could provide in vivo therapy as well as in vivo diagnosis in real-time with minimal invasion.

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Authors and Affiliations

  1. Department of Pathology, The Methodist Hospital, 6565 Fannin Street, Houston, TX, 77030, USA

    Philip T. Cagle MD

  2. Weill Medical College of Cornell University, New York, NY, USA

    Philip T. Cagle MD

Authors
  1. Philip T. Cagle MD
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Correspondence to Philip T. Cagle MD .

Editor information

Editors and Affiliations

  1. , Department of Pathology, The Methodist Hospital, 6565 Fannin Street, Houston, 77030, Texas, USA

    Philip T. Cagle

  2. Health Science Center at Tyler, Department of Pathology, The University of Texas, 11937 US Highway 271, Tyler, 75708, Texas, USA

    Timothy Craig Allen

  3. , Department of Pathology, Mount Sinai Medical Center, 1 Gustave L. Levy Place, New York, 10029, New York, USA

    Mary Beth Beasley

  4. , Department of Pathology, Brigham and Women's Hospital, 75 Francis St., Boston, 02115, Massachusetts, USA

    Lucian R. Chirieac

  5. Medical Center, Department of Pathology, University of Pittsburgh, 200 Lothrop St. - PUH C608, Pittsburgh, 15213, Pennsylvania, USA

    Sanja Dacic

  6. Medical Center, Department of Pathology &, Columbia University, 630 W. 168th Street VC-14-215, New York, 10032, New York, USA

    Alain C. Borczuk

  7. Medical School, Department of Pathology, Aberdeen University, Foresterhill, Aberdeen, Scotland, AB25 2ZD, United Kingdom

    Keith M. Kerr

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© 2012 Springer Science+Business Media New York

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Cagle, P.T. (2012). New Techniques for Optical and Molecular Visualization of Lung Cancer. In: Cagle, P., et al. Molecular Pathology of Lung Cancer. Molecular Pathology Library, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3197-8_12

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  • DOI: https://doi.org/10.1007/978-1-4614-3197-8_12

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-3196-1

  • Online ISBN: 978-1-4614-3197-8

  • eBook Packages: MedicineMedicine (R0)

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