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Trends in Cell Culture Technology

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New Technologies for Toxicity Testing

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 745))

Abstract

Dynamic macroscale bioreactor systems are the most recent breakthrough in cell culture technology. This major achievement, at the beginning of the 21st century, fortunately coincided with an embarrassing gap in the measures to predict the safety and modes of action of chemicals, cosmetics, air particles and pharmaceuticals. The major hurdles to the translation of these breakthrough achievements of cell culture technology into meaningful solutions for predictive high throughput substance testing remain miniaturization from the milliliter to the microliter scale and the supply of relevant amounts of standardized human tissue. This chapter provides insights into the latest developments in this area, illustrates an original multi-micro-organ bioreactor concept and identifies highways for closing the gap.

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Author information

Authors and Affiliations

  1. ProBioGen AG, Berlin, Germany

    Uwe Marx

Authors
  1. Uwe Marx
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Editor information

Editors and Affiliations

  1. FRAME, Nottingham, UK

    Michael Balls DPhil

  2. Norwich, UK

    Robert D. Combes PhD (Independent Consultant) (Independent Consultant)

  3. Nottingham, UK

    Nirmala Bhogal PhD (Independent Consultant) (Independent Consultant)

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© 2012 Landes Bioscience and Springer Science+Business Media

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Marx, U. (2012). Trends in Cell Culture Technology. In: Balls, M., Combes, R.D., Bhogal, N. (eds) New Technologies for Toxicity Testing. Advances in Experimental Medicine and Biology, vol 745. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3055-1_3

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