Advertisement

Physical Activity and Recovery from Hematological Malignancy

  • Luisa Soares-Miranda
  • Carmen Fiuza-Luces
  • Alejandro Lucia
Chapter
Part of the Energy Balance and Cancer book series (EBAC, volume 5)

Abstract

Traditionally, physicians would recommend cancer patients to rest during and after treatments and to avoid activity. However, recently, physical activity has been associated with benefits during and after cancer treatments. There is growing interest in physical activity interventions as a way to ameliorate the side effects of cancer treatments. Studies have shown that physical activity is safe and feasible during and after hematological cancer treatments. Improvements in aerobic capacity, muscular strength, body composition, fatigue, depression, and quality of life were observed in hematological cancer patients engaging in physical activity interventions. However the optimal physical activity dose for these patients is not known and further research is needed.

Keywords

Physical Activity Hematopoietic Stem Cell Transplantation Resistance Training Exercise Intervention Physical Activity Intervention 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Courneya KS, Friedenreich CM (2001) Framework PEACE: an organizational model for examining physical exercise across the cancer experience. Ann Behav Med 23(4):263–272PubMedCrossRefGoogle Scholar
  2. 2.
    Lucia A, Earnest C, Perez M (2003) Cancer-related fatigue: can exercise physiology assist oncologists? Lancet Oncol 4(10):616–625PubMedCrossRefGoogle Scholar
  3. 3.
    Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA et al (2007) Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 39(8):1423–1434PubMedCrossRefGoogle Scholar
  4. 4.
    Turner-Gomes SO, Lands LC, Halton J, Hanning RM, Heigenhauser GJ, Pai M et al (1996) Cardiorespiratory status after treatment for acute lymphoblastic leukemia. Med Pediatr Oncol 26(3):160–165PubMedCrossRefGoogle Scholar
  5. 5.
    Felder-Puig R, di Gallo A, Waldenmair M, Norden P, Winter A, Gadner H et al (2006) Health-related quality of life of pediatric patients receiving allogeneic stem cell or bone marrow transplantation: results of a longitudinal, multi-center study. Bone Marrow Transplant 38(2):119–126PubMedCrossRefGoogle Scholar
  6. 6.
    Duggan C, Bechard L, Donovan K, Vangel M, O’Leary A, Holmes C et al (2003) Changes in resting energy expenditure among children undergoing allogeneic stem cell transplantation. Am J Clin Nutr 78(1):104–109PubMedGoogle Scholar
  7. 7.
    White AC, Terrin N, Miller KB, Ryan HF (2005) Impaired respiratory and skeletal muscle strength in patients prior to hematopoietic stem-cell transplantation. Chest 128(1):145–152PubMedCrossRefGoogle Scholar
  8. 8.
    Wiskemann J, Huber G (2008) Physical exercise as adjuvant therapy for patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant 41(4):321–329PubMedCrossRefGoogle Scholar
  9. 9.
    Warner JT, Bell W, Webb DK, Gregory JW (1997) Relationship between cardiopulmonary response to exercise and adiposity in survivors of childhood malignancy. Arch Dis Child 76(4):298–303PubMedCrossRefGoogle Scholar
  10. 10.
    Watson T, Mock V (2004) Exercise as an intervention for cancer-related fatigue. Phys Ther 84(8):736–743PubMedGoogle Scholar
  11. 11.
    Mock V (2004) Evidence-based treatment for cancer-related fatigue. J Natl Cancer Inst Monogr 32:112–118PubMedCrossRefGoogle Scholar
  12. 12.
    Lajous M, Mozaffarian D, Mozaffarian R, Schrag D, Adami HO (2011) Lifestyle prescriptions for cancer survivors and their communities. J Intern Med 269(1):88–93PubMedCrossRefGoogle Scholar
  13. 13.
    Courneya KS, Friedenreich CM (2007) Physical activity and cancer control. Semin Oncol Nurs 23(4):242–252PubMedCrossRefGoogle Scholar
  14. 14.
    Doyle C, Kushi LH, Byers T, Courneya KS, Demark-Wahnefried W, Grant B et al (2006) Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. CA Cancer J Clin 56(6):323–353PubMedCrossRefGoogle Scholar
  15. 15.
    Physical Activity Guidelines Committee (2008) Physical Activity Guidelines Advisory Committee Report. Physical Activity Guidelines Committee Services DoHaH, Washington, DCGoogle Scholar
  16. 16.
    Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, Pinto BM et al (2010) American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42(7):1409–1426PubMedCrossRefGoogle Scholar
  17. 17.
    Walsh NP, Gleeson M, Shephard RJ, Woods JA, Bishop NC, Fleshner M et al (2011) Position statement. Part one: Immune function and exercise. Exerc Immunol Rev 17:6–63PubMedGoogle Scholar
  18. 18.
    Ehrman JK (ed) (2010) ACSM’s Resource Manual for Guidelined for exercise testing and prescription, 6th edn. Wolters Kluwer, Lippincott Williams & Wilkins, New YorkGoogle Scholar
  19. 19.
    Holmes MD, Chen WY, Feskanich D, Kroenke CH, Colditz GA (2005) Physical activity and survival after breast cancer diagnosis. JAMA 293(20):2479–2486PubMedCrossRefGoogle Scholar
  20. 20.
    Irwin ML, Smith AW, McTiernan A, Ballard-Barbash R, Cronin K, Gilliland FD et al (2008) Influence of pre- and postdiagnosis physical activity on mortality in breast cancer survivors: the health, eating, activity, and lifestyle study. J Clin Oncol 26(24):3958–3964PubMedCrossRefGoogle Scholar
  21. 21.
    Meyerhardt JA, Giovannucci EL, Holmes MD, Chan AT, Chan JA, Colditz GA et al (2006) Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol 24(22):3527–3534PubMedCrossRefGoogle Scholar
  22. 22.
    Meyerhardt JA, Heseltine D, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ et al (2006) Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol 24(22):3535–3541PubMedCrossRefGoogle Scholar
  23. 23.
    Hayes S, Davies PS, Parker T, Bashford J, Newman B (2004) Quality of life changes following peripheral blood stem cell transplantation and participation in a mixed-type, moderate-intensity, exercise program. Bone Marrow Transplant 33(5):553–558PubMedCrossRefGoogle Scholar
  24. 24.
    Hayes SC, Davies PS, Parker TW, Bashford J, Green A (2004) Role of a mixed type, moderate intensity exercise programme after peripheral blood stem cell transplantation. Br J Sports Med 38(3):304–309, discussion 309Google Scholar
  25. 25.
    Ruiz JR, Fleck SJ, Vingren JL, Ramirez M, Madero L, Fragala MS et al (2009) Preliminary findings of a 4-month intra-hospital exercise training intervention on IGFs and IGFBPs in children with leukemia. J Strength Cond Res 24(5):1292–1297CrossRefGoogle Scholar
  26. 26.
    San Juan AF, Chamorro-Vina C, Moral S, Fernandez del Valle M, Madero L, Ramirez M et al (2008) Benefits of intrahospital exercise training after pediatric bone marrow transplantation. Int J Sports Med 29(5):439–446PubMedCrossRefGoogle Scholar
  27. 27.
    Battaglini CL, Hackney AC, Garcia R, Groff D, Evans E, Shea T (2009) The effects of an exercise program in leukemia patients. Integr Cancer Ther 8(2):130–138PubMedCrossRefGoogle Scholar
  28. 28.
    Blaauwbroek R, Bouma MJ, Tuinier W, Groenier KH, de Greef MH, Meyboom-de Jong B et al (2008) The effect of exercise counselling with feedback from a pedometer on fatigue in adult survivors of childhood cancer: a pilot study. Support Care Cancer. 2009 August; 17(8):1041–1048 Published online 2008 November 18. doi: 10.1007/s00520-008-0533-yGoogle Scholar
  29. 29.
    Chang PH, Lai YH, Shun SC, Lin LY, Chen ML, Yang Y et al (2008) Effects of a walking intervention on fatigue-related experiences of hospitalized acute myelogenous leukemia patients undergoing chemotherapy: a randomized controlled trial. J Pain Symptom Manage 35(5):524–534PubMedCrossRefGoogle Scholar
  30. 30.
    Courneya KS, Sellar CM, Stevinson C, McNeely ML, Peddle CJ, Friedenreich CM et al (2009) Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. J Clin Oncol 27(27):4605–4612PubMedCrossRefGoogle Scholar
  31. 31.
    Courneya KS, Sellar CM, Stevinson C, McNeely ML, Friedenreich CM, Peddle CJ et al (2009) Moderator effects in a randomized controlled trial of exercise training in lymphoma patients. Cancer Epidemiol Biomarkers Prev 18(10):2600–2607PubMedCrossRefGoogle Scholar
  32. 32.
    Elter T, Stipanov M, Heuser E, von Bergwelt-Baildon M, Bloch W, Hallek M et al (2009) Is physical exercise possible in patients with critical cytopenia undergoing intensive chemotherapy for acute leukaemia or aggressive lymphoma? Int J Hematol 90(2):199–204PubMedCrossRefGoogle Scholar
  33. 33.
    Cohen L, Warneke C, Fouladi RT, Rodriguez MA, Chaoul-Reich A (2004) Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma. Cancer 100(10):2253–2260PubMedCrossRefGoogle Scholar
  34. 34.
    Oldervoll LM, Kaasa S, Knobel H, Loge JH (2003) Exercise reduces fatigue in chronic fatigued Hodgkins disease survivors–results from a pilot study. Eur J Cancer 39(1):57–63PubMedCrossRefGoogle Scholar
  35. 35.
    Cunningham BA, Morris G, Cheney CL, Buergel N, Aker SN, Lenssen P (1986) Effects of resistive exercise on skeletal muscle in marrow transplant recipients receiving total parenteral nutrition. J Parenter Enteral Nutr 10(6):558–563Google Scholar
  36. 36.
    Dimeo F, Schwartz S, Fietz T, Wanjura T, Boning D, Thiel E (2003) Effects of endurance ­training on the physical performance of patients with hematological malignancies during ­chemotherapy. Support Care Cancer 11(10):623–628PubMedCrossRefGoogle Scholar
  37. 37.
    Kim SD, Kim HS (2006) A series of bed exercises to improve lymphocyte count in allogeneic bone marrow transplantation patients. Eur J Cancer Care (Engl) 15(5):453–457CrossRefGoogle Scholar
  38. 38.
    DeFor TE, Burns LJ, Gold EM, Weisdorf DJ (2007) A randomized trial of the effect of a walking regimen on the functional status of 100 adult allogeneic donor hematopoietic cell transplant patients. Biol Blood Marrow Transplant 13(8):948–955PubMedCrossRefGoogle Scholar
  39. 39.
    Dimeo F, Bertz H, Finke J, Fetscher S, Mertelsmann R, Keul J (1996) An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation. Bone Marrow Transplant 18(6):1157–1160PubMedGoogle Scholar
  40. 40.
    Mello M, Tanaka C, Dulley FL (2003) Effects of an exercise program on muscle performance in patients undergoing allogeneic bone marrow transplantation. Bone Marrow Transplant 32(7):723–728PubMedCrossRefGoogle Scholar
  41. 41.
    Hayes S, Davies PS, Parker T, Bashford J (2003) Total energy expenditure and body composition changes following peripheral blood stem cell transplantation and participation in an exercise programme. Bone Marrow Transplant 31(5):331–338PubMedCrossRefGoogle Scholar
  42. 42.
    Hayes SC, Rowbottom D, Davies PS, Parker TW, Bashford J (2003) Immunological changes after cancer treatment and participation in an exercise program. Med Sci Sports Exerc 35(1):2–9PubMedCrossRefGoogle Scholar
  43. 43.
    Carlson LE, Smith D, Russell J, Fibich C, Whittaker T (2006) Individualized exercise program for the treatment of severe fatigue in patients after allogeneic hematopoietic stem-cell transplant: a pilot study. Bone Marrow Transplant 37(10):945–954PubMedCrossRefGoogle Scholar
  44. 44.
    Coleman EA, Coon S, Hall-Barrow J, Richards K, Gaylor D, Stewart B (2003) Feasibility of exercise during treatment for multiple myeloma. Cancer Nurs 26(5):410–419PubMedCrossRefGoogle Scholar
  45. 45.
    Coleman EA, Coon SK, Kennedy RL, Lockhart KD, Stewart CB, Anaissie EJ et al (2008) Effects of exercise in combination with epoetin alfa during high-dose chemotherapy and autologous peripheral blood stem cell transplantation for multiple myeloma. Oncol Nurs Forum 35(3):E53–E61PubMedCrossRefGoogle Scholar
  46. 46.
    Coleman EA, Hall-Barrow J, Coon S, Stewart CB (2003) Facilitating exercise adherence for patients with multiple myeloma. Clin J Oncol Nurs 7(5):529–534, 540Google Scholar
  47. 47.
    Decker WA, Turner-McGlade J, Fehir KM (1989) Psychosocial aspects and the physiological effects of a cardiopulmonary exercise program in patients undergoing bone marrow transplantation (BMT) for acute leukemia (AL). Transplant Proc 21(1 Pt 3):3068–3069PubMedGoogle Scholar
  48. 48.
    Shelton ML, Lee JQ, Morris GS, Massey PR, Kendall DG, Munsell MF et al (2009) A randomized control trial of a supervised versus a self-directed exercise program for allogeneic stem cell transplant patients. Psychooncology 18(4):353–359PubMedCrossRefGoogle Scholar
  49. 49.
    Wilson RW, Jacobsen PB, Fields KK (2005) Pilot study of a home-based aerobic exercise program for sedentary cancer survivors treated with hematopoietic stem cell transplantation. Bone Marrow Transplant 35(7):721–727PubMedCrossRefGoogle Scholar
  50. 50.
    Wiskemann J, Dreger P, Schwerdtfeger R, Bondong A, Huber G, Kleindienst N et al (2011) Effects of a partly self-administered exercise program before, during, and after allogeneic stem cell transplantation. Blood 117(9):2604–2613PubMedCrossRefGoogle Scholar
  51. 51.
    Dimeo F, Fetscher S, Lange W, Mertelsmann R, Keul J (1997) Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood 90(9):3390–3394PubMedGoogle Scholar
  52. 52.
    Wilson DB, Porter JS, Parker G, Kilpatrick J (2005) Anthropometric changes using a walking intervention in African American breast cancer survivors: a pilot study. Prev Chronic Dis 2(2):A16PubMedGoogle Scholar
  53. 53.
    Schmitz KH, Holtzman J, Courneya KS, Masse LC, Duval S, Kane R (2005) Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 14(7):1588–1595PubMedCrossRefGoogle Scholar
  54. 54.
    Marchese VG, Chiarello LA, Lange BJ (2004) Effects of physical therapy intervention for children with acute lymphoblastic leukemia. Pediatr Blood Cancer 42(2):127–133PubMedCrossRefGoogle Scholar
  55. 55.
    Takken T, van der Torre P, Zwerink M, Hulzebos EH, Bierings M, Helders PJ et al (2009) Development, feasibility and efficacy of a community-based exercise training program in pediatric cancer survivors. Psychooncology 18(4):440–448PubMedCrossRefGoogle Scholar
  56. 56.
    San Juan AF, Fleck SJ, Chamorro-Vina C, Mate-Munoz JL, Moral S, Perez M et al (2007) Effects of an intrahospital exercise program intervention for children with leukemia. Med Sci Sports Exerc 39(1):13–21PubMedCrossRefGoogle Scholar
  57. 57.
    San Juan AF, Fleck SJ, Chamorro-Vina C, Mate-Munoz JL, Moral S, Garcia-Castro J et al (2007) Early-phase adaptations to intrahospital training in strength and functional mobility of children with leukemia. J Strength Cond Res 21(1):173–177PubMedCrossRefGoogle Scholar
  58. 58.
    Moyer-Mileur LJ, Ransdell L, Bruggers CS (2009) Fitness of children with standard-risk acute lymphoblastic leukemia during maintenance therapy: response to a home-based exercise and nutrition program. J Pediatr Hematol Oncol 31(4):259–266PubMedCrossRefGoogle Scholar
  59. 59.
    Sharkey AM, Carey AB, Heise CT, Barber G (1993) Cardiac rehabilitation after cancer therapy in children and young adults. Am J Cardiol 71(16):1488–1490PubMedCrossRefGoogle Scholar
  60. 60.
    Shore S, Shepard RJ (1999) Immune responses to exercise in children treated for cancer. J Sports Med Phys Fitness 39(3):240–243PubMedGoogle Scholar
  61. 61.
    Keats MR, Culos-Reed SN (2008) A community-based physical activity program for adolescents with cancer (project TREK): program feasibility and preliminary findings. J Pediatr Hematol Oncol 30(4):272–280PubMedCrossRefGoogle Scholar
  62. 62.
    Hartman A, Te Winkel ML, Van Beek RD, de Muinck Keizer-Schrama SM, Kemper HC, Hop WC et al (2009) A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 53(1):64–71PubMedCrossRefGoogle Scholar
  63. 63.
    Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B et al (1998) Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351(9113):1393–1396PubMedCrossRefGoogle Scholar
  64. 64.
    Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P et al (1998) Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 279(5350):563–566PubMedCrossRefGoogle Scholar
  65. 65.
    Tower RL, Spector LG (2007) The epidemiology of childhood leukemia with a focus on birth weight and diet. Crit Rev Clin Lab Sci 44(3):203–242PubMedCrossRefGoogle Scholar
  66. 66.
    Ladha AB, Courneya KS, Bell GJ, Field CJ, Grundy P (2006) Effects of acute exercise on neutrophils in pediatric acute lymphoblastic leukemia survivors: a pilot study. J Pediatr Hematol Oncol 28(10):671–677PubMedCrossRefGoogle Scholar
  67. 67.
    Chamorro-Vina C, Ruiz JR, Santana-Sosa E, Vicent MG, Madero L, Perez M et al (2009) Exercise during hematopoietic stem cell transplant hospitalization in children. Med Sci Sports Exerc 42(6):1045–1053Google Scholar
  68. 68.
    Courneya KS (2009) Effects of aerobic exercise on physical functioning and quality of life in lymphoma patients: a randomized controlled trial. J Clin Oncol 2009:1–21Google Scholar
  69. 69.
    Demark-Wahnefried W, Aziz NM, Rowland JH, Pinto BM (2005) Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer. J Clin Oncol 23(24):5814–5830PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Luisa Soares-Miranda
    • 1
  • Carmen Fiuza-Luces
    • 2
  • Alejandro Lucia
    • 2
  1. 1.Research Center in Physical Activity, Health and Leisure, Faculty of SportUniversity of PortoPortoPortugal
  2. 2.Exercise PhysiologyUniversidad Europea de MadridMadridSpain

Personalised recommendations