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Targeting the VEGF Pathway in Renal Cell Carcinoma

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Renal Cell Carcinoma

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Abstract

Renal cell carcinoma (RCC) has been classically characterized by its resistance to traditional chemotherapy, radiotherapy, and hormonal therapy treatments. Cytokine therapy has showed therapeutic benefit in a small percentage of RCC patients. The discovery of key molecular pathways involved in the tumorigenesis of RCC has favored the development of new and more effective therapies. The most successful molecular target identified so far is the von Hippel–Lindau (VHL)/hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) pathway, which is known to be altered in most patients with sporadic clear-cell RCC. In the past 6 years, the use of targeted therapies has significantly increased the treatment options for patients with mRCC and improved their perspectives. Sorafenib, the first new generation targeted treatment, received Food and Drug Administration (FDA) approval in 2005 for patients with cytokine-refractory disease. Following sorafenib approval, three other VEGF-targeted agents—sunitinib, bevacizumab, and pazopanib—have been approved for the treatment of metastatic RCC. Currently, these targeted therapies have replaced the use of immunotherapy in the vast majority of mRCC patients.

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Authors and Affiliations

  1. Department of Medical Oncology, Hospital General Vall d”Hebron, Barcelona, Spain

    Cristina Suarez M.D.

  2. Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Glickman Urological and Kidney Institute, 9500 Euclid Avenue/Desk R35, Cleveland, OH, 44195, USA

    Brian I. Rini M.D.

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  1. Cristina Suarez M.D.
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Correspondence to Brian I. Rini M.D. .

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Editors and Affiliations

  1. David Geffen School of Medicine at UCLA, Department of Medicine, Cedars-Sinai Medical Center, n/a, Los Angeles, 90095, California, USA

    Robert A. Figlin

  2. Lineberger Comprehensive Cancer Center, University of North Carolina, Campus Box 7295, Room 21-237, 218, Chapel Hill, 27599-7295, North Carolina, USA

    W. Kimryn Rathmell

  3. Taussig Cancer Institute, Department of Solid Tumor Oncology, Cleveland Clinic, 9500 Euclid Ave, CLEVELAND, 44195-0001, Ohio, USA

    Brian I. Rini

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Suarez, C., Rini, B.I. (2012). Targeting the VEGF Pathway in Renal Cell Carcinoma. In: Figlin, R., Rathmell, W., Rini, B. (eds) Renal Cell Carcinoma. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2400-0_6

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