Abstract
The first epidemic of Minamata disease was observed in Minamata and surrounding areas mainly from the mid-1950s to the mid-1970s, and the second one in the Agano River basin mainly in the 1960s. There are some difficulties in conducting epidemiological study on the health effects of methylmercury among residents of the previously contaminated site. The evaluation of the past exposure level is difficult for methylmercury that has a relatively short biological half-life of 50–70 days in the human body. The limited data on hair mercury concentration obtained in the early 1960s, difference assumed in the exposure level among subpopulations and areas of residence, or methylmercury concentrations of preserved umbilical cord have been used in studies on the health effects of the past exposure. Subjective complaints are important to be considered as possible outcomes on the effects of chronic exposure to methylmercury. However, diagnostic or selection bias should not be underestimated, especially given the possibility of linkage with the compensation of patients. Despite these limitations, epidemiological studies have clarified associations between methylmercury exposure and a variety of health impairments including nonspecific clinical manifestations.
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References
Akagi H, Grandjean P, Takizawa Y, Weihe P. Methylmercury dose estimation from umbilical cord concentrations in patients with Minamata disease. Environ Res. 1998;77:98–103.
Eto K. Minamata disease. Neuropathology. 2000;20(Suppl s1):14–9.
Fujino T. Clinical and epidemiological studies on chronic Minamata disease, part I: study on Katsurajima Island. Kumamoto Med J. 1994;44:139–55.
Fukuda Y, Ushijima K, Kitano T, et al. An analysis of subjective complaints in a population living in a methylmercury-polluted area. Environ Res. 1999;81:100–7.
Futatsuka M. Effects of methylmercury exposure on junior high school children bone in 1955–58 near Minamat bay. Environ Sci. 2001;8:521–31.
Futatsuka M, Nomura S. Studies on epidemiological analysis on clinical signs appearing in areas contaminated with methyl mercury (text in Japanese). Kumamoto Igakkai Zasshi. 1978;52:76–94.
Futatsuka M, Matsushita T, Arimatsu Y, et al. Survey on physical functions of school children in mercury-contaminated districts (text in Japanese). Jpn J Public Health. 1973;20:299–314.
Grandjean P, Satoh H, Murata K, Eto K. Adverse effects of methylmercury: environmental health research implications. Environ Health Perspect. 2010;118:1137–45.
Hachiya N. The history and the present of Minamata disease—entering the second half a century. Jpn Med Assoc J. 2006;49:112–8.
Harada M. Congenital Minamata disease: intrauterine methylmercury poisoning. Teratology. 1978;18:285–8.
Harada M. Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. Crit Rev Toxicol. 1995;25:1–24.
Harada M, Nakanishi J, Konuma S, et al. The present mercury contents of scalp hair and clinical symptoms in inhabitants of the Minamata area. Environ Res. 1998;77:160–4.
Harada M, Akagi TT, et al. Methylmercury level in umbilical cords from patients with congenital Minamata disease. Sci Total Environ. 1999;234:59–62.
Hunter D, Russell D. Focal cerebral and cerebellar atrophy in a human subject due to organic mercury compounds. J Neurol Neurosurg Phychiatry. 1954;17:235–41.
Igata A. Epidemiological and clinical features of Minamata disease. Environ Res. 1993;63:157–69.
Irukayama K. Case history of Minamata. In: Tsubaki T, Irukayama K, editors. Minamata disease. Tokyo: Kodansha-Elsevier; 1977.
Itai Y, Fujino T, Ueno K, Motomatsu Y. An epidemiological study of the incidence of abnormal pregnancy in areas heavily contaminated with methylmercury. Environ Sci. 2004;11:83–97.
Kinjo Y, Akiba S, Yamaguchi N, et al. Cancer mortality in Minamata disease patients exposed to methylmercury through fish diet. J Epidemiol. 1996;6:134–8.
Kitamura S, Miyata C, Tomita M, et al. Epidemiological investigation of the unknown central nervous disorder in the Minamata district (in Japanese). Kumamoto Igakkai Zasshi. 1957;31 Suppl 1:1–9.
Kitamura S, Ueda K, Niino J, et al. Chemical examination on the cause of Minamata disease V (in Japanese). Kumamoto Igakkai Zasshi. 1960;34 Suppl 3:593–601.
Kondo K. Incidence of Minamata disease in communities along the Agano River, Niigata, Japan, Patterns of the exposure and official diagnosis of patients (text in Japanese). Jpn J Hyg. 1996;51:599–611.
Kumamoto Prefecture (1998) Environmental restoration of Minamata Bay. In An outline of the environmental restoration of Minamata Bay, Kumamoto Prefecture, Kumamoto.
Kurland LT, Faro SN, Siedler H. Minamata disease. The outbreak of a neurologic disorder in Minamata, Japan, and its relationship to the ingestion of seafood contaminated by mercuric compounds. World Neurol. 1960;1:370–95.
Matsushima Y. Survey on mercury concentration in hair for Minamata disease (in Japanese). Ann Kumamoto Pref Inst Health Res. 1970;1970:13–45.
Moriyama H, Futatsuka M, Kinjo Y. Fetal Minamata disease. Environ Sci. 1994;3:15–23.
Nakagawa M, Kodama T, Akiba S, et al. Logistic model analysis of neurological findings in Mnamata disease and the predicting index. Intern Med. 2002;41:14–9.
Nishimura H, Okamoto T. Science of Minamata disease (Japanese). Tokyo: Nippon Hyoronsha; 2001.
Oka T, Matsukura M, Okamoto M, et al. Autonomic nervous functions in fetal type Minamata disease patients: assessment of heart rate variability. Tohoku J Exp Med. 2003;198:215–21.
Rice DC. Evidence for delayed neurotoxicity produced by methylmercury. Neurotoxicology. 1996;17:583–96.
Sakamoto M, Nakano A, Akagi H. Declining Minamata male birth ratio associated with increased male fetal death due to heavy methylmercury pollution. Environ Res. 2001;87:92–8.
Sakamoto M, Murata K, Tsuruta K, et al. Retrospective study on temporal and regional variations of methylmercury concentrations in preserved umbilical cords collected from inhabitants of the Minamata area. Ecotoxicol Environ Saf. 2010;73:1144–9.
Sakata A, Orita T, Koriyama M, et al. Hair mercury survey on inhabitants in Izumi [Japanese]. Ann Kagoshima Prefect Inst Public Health. 1962;2:53–6.
Social Scientific Study Group on Minamata Disease. In the hope of avoiding repetition of tragedy of Minamata disease, National Institute for Minamata disease. 2001. http://www.nimd.go.jp/syakai/webversion/SSSGMDreport.html. Accessed 19 March 2011.
Stern AH. A review of the studies of the cardiovascular health effects of methylmercury with consideration of their suitability for risk assessment. Environ Res. 2005;98:133–42.
Takizawa Y. Epidemioogy of mercury poisoning. In: Nriagu JO, editor. The biogeochemistry of mercury in the environment. New York: Elsevier; 1979.
Tamashiro H, Arakaki M, Futatsuka M, Lee ES. Methylmercury exposure and mortality in southern Japan: a close look at causes of death. J Epidemiol Community Health. 1986;40:181–5.
Tsubaki T, Shirakawa K, Hirota K, Kondo K. Epidemiology of methylmercury poisoning in Niigata. In: Tsubaki T, Irukayama K, editors. Minamata disease. Tokyo: Kodansha-Elsevier; 1977.
Tsuda T, Mino Y, Yamamoto E, et al. Causal inference in medicine: a reaction to the report, “incidence of Minamata disease in communities along the Agano River, Niigata, Japan, Patterns of the exposure and official diagnosis of patients” (text in Japanese). Jpn J Hyg. 1997;52:511–29.
Uchino M, Tanaka Y, Ando Y, et al. Neurologic features of chronic Minamata disease (organic mercury poisoning) and incidence of complications with aging. J Environ Sci Health. 1995;B30:699–715.
Weiss B, Clarkson TW, Simom W. Silent latency periods in methylmercury poisoning and in neurodegenerative disease. Environ Health Perspect. 2002;110 Suppl 5:851–4.
Yasutake A, Matsumoto M, Yamaguchi M, Hachiya N. Current hair mercury levels in Japanese for estimation of methylmercury exposure. J Health Sci. 2004;50:120–5.
Yorifuji T, Tsuda T, Kawakami N. Age standardized cancer mortality ratios in areas heavily exposed to methyl mercury. Int Arch Occup Environ Health. 2007;80:679–88.
Yorifuji T, Tsuda T, Inoue S, et al (2011) Long-term exposure to methylmercury and psychiatric symptoms in residents of Minamata, Japan. Environ Int, 37:907–913.
Yorifuji T, Tsuda T, Takao S, et al. Total mercury content in hair and neurologic signs: historic data from Minamata. Epidemiology. 2009a;20:188–93.
Yorifuji T, Kashima S, Tsuda T, Harada M. What has methylmercury in umbilical cords told us?—Minamata disease. Sci Total Environ. 2009b;408:272–6.
Yorifuji T, Tsuda T, Kashima S, et al. Long-term exposure to methylmercury and its effects on hypertension in Minamata. Environ Res. 2010;110:40–6.
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Hachiya, N. (2012). Epidemiological Update of Methylmercury and Minamata Disease. In: Ceccatelli, S., Aschner, M. (eds) Methylmercury and Neurotoxicity. Current Topics in Neurotoxicity, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2383-6_1
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