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B Lymphocyte-Derived Humoral Immune Defenses in Breast Milk Transmission of the HIV-1

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Human Immunodeficiency Virus type 1 (HIV-1) and Breastfeeding

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 743))

Abstract

The UNAIDS estimated that more than 370,000 (230,000–510,000) children were infected by human immunodeficiency virus (HIV) type 1 through mother-to-child transmission (MTCT) worldwide in 2009, with the majority (>90%) occurring in sub-Saharan Africa (a drop of 24% from 5 years earlier) [1]. The majority of MTCT occurs during pregnancy and birth. In addition, postnatal transmission of HIV from HIV-infected mother to her child through prolonged breastfeeding is well recognized, and may account for one-third to half of new infant HIV infections worldwide [2–10]. While studies of maternal or infant antiretroviral prophylaxis during the period of breastfeeding have shown substantial potential for reduction of infant HIV infections [11–14], postnatal virus transmissions may continue to occur even in the setting of optimal antiretroviral prophylaxis. Therefore, development of immunologic strategies to reduce HIV transmission via breast milk remains important to improving survival of infants born to HIV-infected mothers in the developing world.

The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

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  1. Sorbonne Paris Cité (Paris V), and Laboratoire de Virologie, Hôpital Européen Georges Pompidou, Université Paris Descartes, 15-20 rue Leblanc, 75 908, Paris Cedex 15, France

    Laurent Bélec M.D., Ph.D., M.P.H.

  2. Division of Reproductive Health, NCCDPHP, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, MSK34, Atlanta, GA, 30341, USA

    Athena P. Kourtis M.D., Ph.D., M.P.H.

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  1. Laurent Bélec M.D., Ph.D., M.P.H.
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  1. School of Medicine, Emory University, Buford Highway 4770, Atlanta, 30341, Georgia, USA

    Athena P. Kourtis

  2. and Prevention, Global AIDS Program - China, Centers for Disease Control, Emory University School of Medicine, Beijing, 100600, China, People's Republic

    Marc Bulterys

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Bélec, L., Kourtis, A.P. (2012). B Lymphocyte-Derived Humoral Immune Defenses in Breast Milk Transmission of the HIV-1. In: Kourtis, A., Bulterys, M. (eds) Human Immunodeficiency Virus type 1 (HIV-1) and Breastfeeding. Advances in Experimental Medicine and Biology, vol 743. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-2251-8_10

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