Weaning and Extubation

  • Steven M. Donn
  • Sunil K. Sinha


Minute Ventilation Peak Inspiratory Pressure Alveolar Ventilation Respiratory Drive Double Aortic Arch 
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Suggested Reading

  1. Balsan MJ, Jones JG, Watchko JF, Guthrie RD. Measurements of pulmonary mechanics prior to the elective extubation of neonates. Pediatr Pulmonol. 1990;9:238–43.PubMedCrossRefGoogle Scholar
  2. Barrington KJ, Finer NN. A randomized, controlled trial of aminophylline in ventilatory weaning of premature infants. Crit Care Med. 1993;21:846–50.PubMedCrossRefGoogle Scholar
  3. Baumeister BL, El-Khatib M, Smith PG, Blumer JL. Evaluation of predictors of weaning from mechanical ventilation in pediatric patients. Pediatr Pulmonol. 1997;24:344–52.PubMedCrossRefGoogle Scholar
  4. Bernstein G, Mannino FL, Heldt GP, et al. Randomized multicenter trial comparing synchronized and conventional intermittent mandatory ventilation in neonates. J Pediatr. 1996;128:453–63.PubMedCrossRefGoogle Scholar
  5. Browne LP. What is the optimal imaging for vascular rings and slings? Pediatr Radiol. 2009;39:S191–5.PubMedCrossRefGoogle Scholar
  6. Chan V, Greenough A. Comparison of weaning by patient triggered ventilation or synchronous intermittent mandatory ventilation in preterm infants. Acta Paediatr. 1994;83:335–7.PubMedCrossRefGoogle Scholar
  7. Davis P, Jankow R, Doyle L, Henschke P. Randomised, controlled trial of nasal continuous positive pressure in the extubation of infants weighing 600 to 1250 g. Arch Dis Child. 1998;79:F54–7.Google Scholar
  8. Dimitriou G, Greenough A, Laubscher B. Lung volume measurements immediately after extubation by prediction of “extubation failure” in premature infants. Pediatr Pulmonol. 1996;21:250–4.PubMedCrossRefGoogle Scholar
  9. Donn SM, Sinha SK. Controversies in patient-triggered ventilation. Clin Perinatol. 1998;25:49–61.PubMedGoogle Scholar
  10. El-Khatib MF, Baumeister B, Smith PG, et al. Inspiratory pressure/maximal inspiratory pressure: does it predict successful extubation in critically ill infants and children? Intensive Care Med. 1996;22:264–8.PubMedCrossRefGoogle Scholar
  11. Fiastro JF, Habib MP, Quan SF. Pressure support compensation for inspiratory work due to endotracheal tubes and demand continuous positive airway pressure. Chest. 1988;93:499–505.PubMedCrossRefGoogle Scholar
  12. Gillespie LM, White SD, Sinha SK, Donn SM. Usefulness of the minute ventilation test in predicting successful extubation in newborn infants: a randomized clinical trial. J Perinatol. 2003;23:205–7.PubMedCrossRefGoogle Scholar
  13. Gupta S, Sinha S, Tin W, Donn SM. A randomized controlled trial of post-extubation bubble continuous positive airway pressure versus infant flow driver continuous positive airway pressure in preterm infants with respiratory distress syndrome. J Pediatr. 2009;154:645–50.PubMedCrossRefGoogle Scholar
  14. Halliday HL. Towards earlier neonatal extubation. Lancet. 2000;355:2091.PubMedCrossRefGoogle Scholar
  15. McIntyre NR, Leatherman NE. Mechanical loads on the ventilatory muscles. Am Rev Respir Dis. 1989;139:968–72.Google Scholar
  16. Robertson NJ, Hamilton PA. Randomised trial of elective continuous positive airway pressure (CPAP) compared with rescue CPAP after extubation. Arch Dis Child. 1998;79:F58–60.Google Scholar
  17. Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, Solimano A, Tin W. Caffeine for apnea of prematurity trial group. N Engl J Med. 2006;354(20):2112–21.PubMedCrossRefGoogle Scholar
  18. Sheth RD, Pryse-Phillips WEM, Riggs JE, Bodensteiner JB. Critical illness neuromuscular disease in children manifested as ventilator dependence. J Pediatr. 1995;126:259–61.PubMedCrossRefGoogle Scholar
  19. Sillos EM, Veber M, Schulman M, et al. Characteristics associated with successful weaning in ventilator-dependent preterm infants. Am J Perinatol. 1992;9:374–7.PubMedCrossRefGoogle Scholar
  20. Sinha SK, Donn SM. Weaning newborns from mechanical ventilation. Semin Neonatol. 2002a;7:421–8.PubMedCrossRefGoogle Scholar
  21. Sinha SK, Donn SM. Difficult extubation in babies receiving assisted mechanical ventilation. Arch Dis Child Educ Pract Ed. 2006;91:ep42–6.CrossRefGoogle Scholar
  22. Sinha SK, Donn SM, Gavey J, McCarty M. A randomised trial of volume-controlled versus time-cycled, pressure-limited ventilation in preterm infants with respiratory distress syndrome. Arch Dis Child. 1997;77:F202–5.Google Scholar
  23. Sinha SK, Donn SM. Weaning newborns from mechanical ventilation. Semin Neonatol. 2002b;7:421–8.PubMedCrossRefGoogle Scholar
  24. Tapia JL, Cancalari A, Gonzales A, Mercado ME. Does continuous positive airway pressure (CPAP) during weaning from intermittent mandatory ventilation in very low birth weight infants have risks or benefits? A controlled trial. Pediatr Pulmonol. 1995;19:269–74.PubMedCrossRefGoogle Scholar
  25. Veness-Meehan KA, Richter S, Davis JM. Pulmonary function testing prior to extubation in infants with respiratory distress syndrome. Pediatr Pulmonol. 1990;9:2–6.PubMedCrossRefGoogle Scholar
  26. Walsh MC, Fanaroff JM. Meconium stained fluid: approach to the mother and the baby. Clin Perinatol. 2007;34:653–65.PubMedCrossRefGoogle Scholar
  27. Wilson Jr BJ, Becker MA, Linton ME, Donn SM. Spontaneous minute ventilation predict readiness for extubation in mechanically ventilated preterm infants? J Perinatol. 1998;18:436–9.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Division of Neonatal-Perinatal MedicineC.S. Mott Children’s Hospital, F5790 Mott Hospital/5254, University of Michigan Health SystemAnn ArborUSA
  2. 2.Department of Neonatal MedicineThe James Cook University Hospital, University of DurhamMiddlesbroughUK

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