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Oxygen Toxicity

  • Ola Didrik SaugstadEmail author
Chapter
  1. I.
    Oxygen toxicity in the newborn period
    1. A.
      Historical aspects
      1. 1.

        Oxygen was discovered independently by Scheele and Priestly in 1772 and 1774, respectively. However, already in 1604 the Polish alchemist Michael Sendivogius had described oxygen as vital air.

         
      2. 2.

        Lavoisier coined the term oxygen in 1775. Only 5 years later oxygen was used to treat newborns. In 1928, Flagg published in the Journal of the American Medical Association (JAMA) a method to resuscitate newborns with oxygen and CO2.

         
      3. 3.

        Already Priestly understood that oxygen might be toxic and during the nineteenth century more and more information was collected showing its toxic effects.

         
      4. 4.

        In the 1950s, oxygen was associated with the development of retrolental fibroplasia today called retinopathy of prematurity (ROP), and at the end of the 1960s oxygen toxicity was associated with the development of bronchopulmonary dysplasia (BPD).

         
      5. 5.

        Some years later, it was hypothesized oxygen might be toxic during resuscitation and...

Keywords

Vascular Endothelial Growth Factor Arterial Oxygen Saturation Oxygen Toxicity Delivery Room Late Preterm Infant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Suggested Reading

  1. Bhandari V. Molecular mechanisms of hyperoxia-induced acute lung injury. Front Biosci. 2008;13:6653–61.PubMedCrossRefGoogle Scholar
  2. Bhandari V. Hyperoxia-derived lung damage in preterm infants. Semin Fetal Neonatal Med. 2010;15:223–9.PubMedCrossRefGoogle Scholar
  3. Barrington KJ, Finer N. Inhaled nitric oxide for respiratory failure in preterm infants. Cochrane Database Syst Rev. 2010 Dec 8; (12):CD000509.Google Scholar
  4. Chen J, Smith LE. Retinopathy of prematurity. Angiogenesis. 2007;10:133–40.PubMedCrossRefGoogle Scholar
  5. Chen ML, Guo L, Smith LE, Dammann CE, Dammann O. High or low oxygen saturation and severe retinopathy of prematurity: a meta-analysis. Pediatrics. 2010;125:e1483–92.PubMedCrossRefGoogle Scholar
  6. Dawson JA, Kamlin CO, Vento M, Wong C, Cole TJ, Donath SM, Davis PG, Morley CJ. Defining the reference range for oxygen saturation for infants after birth. Pediatrics. 2010;125:e1340–7.PubMedCrossRefGoogle Scholar
  7. Dennery PA. Oxidative stress in development: nature or nurture? Free Radic Biol Med. 2010;49:1147–51.PubMedCrossRefGoogle Scholar
  8. Gerstner B, DeSilva TM, Genz K, Armstrong A, Brehmer F, Neve RL, Felderhoff-Mueser U, Volpe JJ, Rosenberg PA. Hyperoxia causes maturation-dependent cell death in the developing white matter. J Neurosci. 2008;28:1236–45.PubMedCrossRefGoogle Scholar
  9. Haynes RL, Baud O, Li J, Kinney HC, Volpe JJ, Folkerth DR. Oxidative and nitrative injury in periventricular leukomalacia: a review. Brain Pathol. 2005;15:225–33.PubMedCrossRefGoogle Scholar
  10. Khwaja O, Volpe JJ. Pathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed. 2008;93:F153–61.PubMedCrossRefGoogle Scholar
  11. Lane N. Oxygen: the molecule that made the world. Oxford: Oxford University Press; 2002.Google Scholar
  12. Saugstad OD. Oxidative stress in the newborn–a 30-year perspective. Biol Neonate. 2005;88:228–36.PubMedCrossRefGoogle Scholar
  13. Saugstad OD. Oxygen and oxidative stress in bronchopulmonary dysplasia. J Perinat Med. 2010;38:571–7.PubMedCrossRefGoogle Scholar
  14. Saugstad OD, Aune D. In search of the optimal oxygen saturation for extremely low birth weight infants: a systematic review and meta-analysis. Neonatology. 2011;100:1–8.PubMedCrossRefGoogle Scholar
  15. Tyson JE, Wright LL, Oh W, Kennedy KA, Mele L, Ehrenkranz RA, Stoll BJ, Lemons JA, Stevenson DK, Bauer CR, Korones SB, Fanaroff AA. Vitamin A supplementation for extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. N Engl J Med. 1999;340:1962–8.PubMedCrossRefGoogle Scholar
  16. Vento M, Saugstad OD. Oxygen supplementation in the delivery room: updated information. J Pediatr. 2011;158(2 Suppl):e5–7.PubMedGoogle Scholar
  17. Volpe JJ, Kinney HC, Jensen FE, Rosenberg PA. The developing oligodendrocyte: key cellular target in brain injury in the premature infant. Int J Dev Neurosci. 2011;29:423–40.PubMedCrossRefGoogle Scholar
  18. Wright CJ, Dennery PA. Manipulation of gene expression by oxygen: a primer from bedside to bench. Pediatr Res. 2009;66:3–10.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Pediatric ResearchOslo University Hospital, RikshospitaletOsloNorway

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