Oxygen Toxicity

  • Ola Didrik SaugstadEmail author
  1. I.
    Oxygen toxicity in the newborn period
    1. A.
      Historical aspects
      1. 1.

        Oxygen was discovered independently by Scheele and Priestly in 1772 and 1774, respectively. However, already in 1604 the Polish alchemist Michael Sendivogius had described oxygen as vital air.

      2. 2.

        Lavoisier coined the term oxygen in 1775. Only 5 years later oxygen was used to treat newborns. In 1928, Flagg published in the Journal of the American Medical Association (JAMA) a method to resuscitate newborns with oxygen and CO2.

      3. 3.

        Already Priestly understood that oxygen might be toxic and during the nineteenth century more and more information was collected showing its toxic effects.

      4. 4.

        In the 1950s, oxygen was associated with the development of retrolental fibroplasia today called retinopathy of prematurity (ROP), and at the end of the 1960s oxygen toxicity was associated with the development of bronchopulmonary dysplasia (BPD).

      5. 5.

        Some years later, it was hypothesized oxygen might be toxic during resuscitation and...


Vascular Endothelial Growth Factor Arterial Oxygen Saturation Oxygen Toxicity Delivery Room Late Preterm Infant 
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Pediatric ResearchOslo University Hospital, RikshospitaletOsloNorway

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