Oxygen Therapy

  1. I.
    1. A.

      “The clinician must bear in mind that oxygen is a drug and must be used in accordance with well recognized pharmacologic principles; i.e., since it has certain toxic effects and is not completely harmless (as widely believed in clinical circles) it should be given only in the lowest dosage or concentration required by the particular patient.” [Julius Comroe, 1945].

    2. B.

      Oxygen is the most commonly used therapy in neonatal intensive care units, and ocular oxygen toxicity in newborns (cicatricial retinopathy of prematurity, ROP) was first described more than 50 years ago.

    3. C.

      The ultimate aim of oxygen therapy is to achieve adequate tissue oxygenation, but without creating oxygen toxicity and oxidative stress.

  2. II.
    Physiological considerations
    1. A.
      Tissue oxygenation depends upon:
      1. 1.

        Fractional-inspired oxygen (FiO2).

      2. 2.

        Gas exchange mechanism within the lungs.

      3. 3.

        Cardiac output.

      4. 4.

        Oxygen carrying capacity of the blood. Approximately 97% of oxygen transported...


Oxygen Tension Pulse Oximetry Oxygen Therapy High Oxygen Affinity Fetal Oxygen 
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Suggested Reading

  1. Askie LM, Henderson-Smart DJ, Irwig L, Simpson JM. Oxygen saturation targets and outcomes in extremely preterm infants. N Engl J Med. 2003;349:959–67.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Neonatal MedicineThe James Cook University HospitalMiddlesbroughUK

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