Theoretical Analysis of Molecular Transport Across Membrane Channels and Nanopores
A successful functioning of cellular systems requires that some molecules and ions be transferred out of the cell while other particles should be taken in. The bidirectional flux is accomplished with the help of a complex system of membrane protein channels and pores [1, 2]. It is known that molecular transport across cellular membranes is fast, efficient, selective, and that the functioning of channels is robust with respect to strong nonequilibrium fluctuations in the cellular environment . These observations are especially surprising because in many cases molecular translocation does not involve the use of metabolic energy or significant conformational changes . Although in recent years significant advances in studying molecular transport in biological systems have been achieved, the mechanisms of translocation phenomena are still not well understood.
KeywordsParticle Flux Molecular Transport Particle Current Significant Conformational Change Uniform Channel
- 1.Lodish, H., Berk, A., Zipursky, S.L., Matsudaira, P., Baltimore, D., Darnell, J.: Molecular Cell Biology, 4th edn. W.H. Freeman and Company, New York (2002)Google Scholar
- 2.Hille, B.: Ionic Channels of Excitable Membranes, 3rd edn. Sinauer Associates, Sunderland Massachusetts (2001)Google Scholar
- 4.Wickner, W., Schekman, R.: Protein translocation across biological membranes. Science 310, 1452–1456 (2005)Google Scholar