3 Scanning Electrochemical Microscopy Imaging of DNA Arrays for High Throughput Analysis Applications

Abstract

With the completion of the human genome sequencing efforts, functional genomics, which aims to understand the relationship between an organism's genome and its phenotype, has become a primary research field. Various kinds of biochips, a bio-microarray device, are extensively used for substantial analysis purposes by promoting the effective use of the vast wealth of data produced by genomic projects. The strength of biochips lies in the spatial grid of miniaturized specific binding sites, at which unique binding events can be analyzed simultaneously. Moreover, by introduction into a microfluidic device, the next generation of biochips has been found to possess both biochemical reaction capabilities, including amplification, and chemical analysis. Such a device will be used on a single platform with multiple reactions being carried out on individual sites.