Influence of Different Stem Cell Mobilization Strategies on Graft Composition and Outcome of Autologous or Allogeneic Transplantation

Chapter

Abstract

Autologous and allogeneic hematopoietic stem cell (HSC) transplantation are considered the standard of care for many malignancies including lymphoma, myeloma, and some leukemias. In many cases, mobilized peripheral blood has become the preferred source for HSCs. The efficacy of different mobilization regimens and transplant outcomes based on cell doses has been well studied. However, the characteristics of the stem cell graft may be of equal importance with respect to patient outcomes following autologous or allogeneic transplant. This review summarizes available preclinical and clinical data for bone marrow and mobilized peripheral blood HSC graft characteristics, defined as the cell types found in the graft as well as their gene expression profiles. This manuscript also explores how graft characteristics can impact bone marrow homing, engraftment, immune reconstitution, and other posttransplant outcomes in both the allogeneic and autologous settings.

Keywords

Autologous transplant Allogeneic transplant Plerixafor Chemomobilization Graft characteristics 

Notes

Acknowledgments

S.F. received research funding and honoraria from Genzyme Corporation for clinical studies and oral presentation regarding plerixafor. G.T has nothing to disclose. Financial support for medical editorial assistance was provided by Genzyme Corporation. The authors thank Richard Balzer, Ph.D. (MediTech Media) for medical editorial assistance with this manuscript. We gratefully acknowledge Elsevier’s permission to reuse material.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Center for Tumor Diagnostics and Therapy, Paracelsus KlinikOsnabrückGermany
  2. 2.Department of Medicine, Utah Blood and Marrow Transplant and Myeloma ProgramUniversity of Utah School of MedicineSalt Lake CityUSA

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