Changing Concepts in the 1990s, 2000s, and 2010s: More Overlap and Similarities

  • C. Raymond Lake


In addition to more clinical reports of overlapping phenomenology, an expanding number of recent, comparative, basic science, and preclinical studies from various US and UK laboratories found surprising similarities between patients diagnosed with schizophrenia and bipolar disorder (Table 11.1). Over 150 studies from the 1990s and 2000s were reviewed that either compared some aspects of the two diagnoses and/or supported bipolar disorder as a “bona fide” disorder. Some of these comparative studies are summarized with selected authors’ quotes in Tables 11.2, 11.3, 11.4, 11.5, 11.6, 11.7, 11.8, 11.9, and 11.61.


Bipolar Disorder Mood Disorder Negative Symptom Psychotic Symptom Bipolar Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Authors and Affiliations

  1. 1.Department Psychiatry and Behavioral SciencesUniversity of Kansas, School of MedicineKansas CityUSA

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