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Mitochondria in Neurodegeneration

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Neural Metabolism In Vivo

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 4))

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Abstract

In neurodegenerative diseases, particular parts of the brain, spinal cord, or peripheral nerves functionally fail and the neurons of the dysfunctional region die. Neuroanatomically localizable functional impairment and neurodegeneration associate with recognizable clinical syndromes. Mitochondrial dysfunction is found in numerous neurodegenerative diseases and justifies a “neurodegenerative mitochondriopathy” classification system. The role mitochondrial dysfunction plays in the etiology, pathophysiology, and histopathology of the neurodegenerative mitochondriopathies is not entirely clear at this time, but in different diseases mitochondria may represent a final common pathway, an intermediate step, or even primary driver of neurodegeneration. Mitochondria sit at the nexus of various hypotheses that attempt to explain particular neurodegenerative diseases, and are a therapeutic target.

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  1. Departments of Neurology, Molecular & Integrative Physiology, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA

    Russell H. Swerdlow M.D.

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Correspondence to Russell H. Swerdlow M.D. .

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  1. School of Medicine, Hoglund Brain Imaging Center, University of Kansas, Rainbow Blvd. 3901, Kansas City, 66160, Kansas, USA

    In-Young Choi

  2. Inst. Physique de la Matière Complexe, Labo. d'Imagerie Fonctionnelle et, Ecole Polytechnique Fédérale de Lausanne, Lausanne, 1015, Switzerland

    Rolf Gruetter

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Swerdlow, R.H. (2012). Mitochondria in Neurodegeneration. In: Choi, IY., Gruetter, R. (eds) Neural Metabolism In Vivo. Advances in Neurobiology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-1788-0_30

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