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Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)

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Neural Metabolism In Vivo

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 4))

Abstract

Fluorodeoxyglucose labeled with [18F] (FDG) is a chemical analog of glucose, where a hydrogen atom of a glucose molecule is replaced with a positron emitter [18F]. Like glucose, FDG is metabolized by hexokinase during glycolysis in the cytosol of the cell; however, unlike glucose-6-phosphate, FDG-6-phosphate is not metabolized further but accumulates intracellularly thus allowing visualization and measurement of local metabolic activity. Relatively long-life of FDG as [18F] compound (110 min) and ability to achieve reliable quantitative estimates of cerebral metabolic rate of glucose and distinguish local changes in FDG uptake with visual inspection and semi-quantitative measures make FDG the most commonly used tracer in PET research and clinical neuroimaging. Besides demonstrating high-quality images of the baseline state of brain activity, FDG also provides accurate measures of the magnitude of changes in brain metabolism in response to various physiological stimulations, pharmacological interventions, and functional tests.

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Authors and Affiliations

  1. Department of Radiology, Washington University School of Medicine, 4525 Scott Ave, East Building, 8225, St. Louis, MO, 63110, USA

    Andrei G. Vlassenko M.D., Ph.D.

  2. Department of Radiology, Avid Radiopharmaceuticals, Philadelphia, PA, USA

    Mark A. Mintun M.D.

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  1. Andrei G. Vlassenko M.D., Ph.D.
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  2. Mark A. Mintun M.D.
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Correspondence to Andrei G. Vlassenko M.D., Ph.D. .

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Editors and Affiliations

  1. School of Medicine, Hoglund Brain Imaging Center, University of Kansas, Rainbow Blvd. 3901, Kansas City, 66160, Kansas, USA

    In-Young Choi

  2. Inst. Physique de la Matière Complexe, Labo. d'Imagerie Fonctionnelle et, Ecole Polytechnique Fédérale de Lausanne, Lausanne, 1015, Switzerland

    Rolf Gruetter

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Vlassenko, A.G., Mintun, M.A. (2012). Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET). In: Choi, IY., Gruetter, R. (eds) Neural Metabolism In Vivo. Advances in Neurobiology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-1788-0_10

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