Comparison of the Kinetics of Pulmonary Oxygen Uptake and Middle Cerebral Artery Blood Flow Velocity During Cycling Exercise

  • Mikio HiuraEmail author
  • Norimitsu Kinoshita
  • Sigeki Izumi
  • Tadashi Nariai
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 737)


The present study investigated the changes of pulmonary oxygen uptake (VO2) and the regional cerebral blood flow (rCBF) in constant load of exercise and compared the kinetics of the two parameters. Eight healthy young males performed two sets of constant workload of exercise bouts (10 min) by cycle ergometer with different intensities of moderate and heavy, corresponding to the level of 10–20% below lactate threshold (LT) and between LT and respiratory compensation point (RC), respectively. The kinetics of VO2 and middle cerebral artery blood flow velocity (MCA V mean) at the initial phase of the exercise was expressed by a monoexponential curve fitting model. The response of MCA V mean during the transition from rest to exercise mimicked that of VO2 and the time constant (τ) for VO2 was related to τ for MCA V mean in both the moderate- and heavy-intensity exercise. We speculate that an increase in both cardiac output and skeletal muscle metabolism, as the contributing factors for VO2 during exercise, would be related to the neuronal activation in the corresponding areas of brain and CBF.


Lactate Threshold Cycling Exercise Respiratory Compensation Respiratory Compensation Point Heavy Intensity 
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We acknowledge the technical support provided by Dr. Muneyuki Sakata (Positron Medical Center, Tokyo Metropolitan Institute of Gerontology) and the subjects for their participation.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Mikio Hiura
    • 1
    Email author
  • Norimitsu Kinoshita
    • 1
  • Sigeki Izumi
    • 1
  • Tadashi Nariai
    • 2
  1. 1.Faculty of Sports and Health StudiesHosei UniversityTokyoJapan
  2. 2.Department of NeurosurgeryTokyo Medical and Dental UniversityTokyoJapan

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