Clinical Applications of Tissue Oxygen Saturation Measurements

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (volume 737)

Abstract

This paper describes a number of clinical applications of non-invasive tissue haemoglobin oxygen saturation (StO2) measurements using both visible and near infrared spectrophotometric techniques. In two cases they became routine clinical tools. The applications of visible spectrophotometry described include amputation level viability prediction in critical limb ischaemia, continuous post-operative monitoring of TRAM (transverse rectus abdominis myocutaneous) flaps and the measurement of StO2 in the colon in order to investigate the presence of colonic ischaemia. Near infrared spectroscopy was applied to measure subcutaneous StO2 in abdominal surgical wounds during the post-operative period in order to investigate whether low levels of tissue oxygenation were associated with subsequent surgical site infections (SSIs) and whether there may be a predictive minimum level of subcutaneous SO2 (SsctO2) that could be used as an indicator for early intervention to prevent SSIs. All of the above applications demonstrated the significant contribution that tissue oxygen saturation measurements can make to clinical diagnosis and monitoring.

Keywords

Catheter Spectrophotometry 

Notes

Acknowledgments

It is not possible here to list everyone who has helped in some way with the above projects. However, the author is most grateful for the collaboration of many clinical colleagues in facilitating the studies and, in particular, to former Surgical Research Fellows Charlotte Ives and Daya Singh for carrying them out.

References

  1. 1.
    Newton DJ, Harrison DK, Hanna GB et al (1997) Microvascular blood flow and oxygen supply in ulcerated skin of the lower limb. Adv Exp Med Biol 428:21–26PubMedCrossRefGoogle Scholar
  2. 2.
    Harrison DK, McCollum PT, Newton DJ et al (1995) Amputation level assessment using lightguide spectrophotometry. Prosthet Orthot Int 19:139–147PubMedGoogle Scholar
  3. 3.
    Hanson JM, Harrison DK and Hawthorn IE (2002) Tissue spectrophotometry and thermographic imaging applied to routine clinical prediction of amputation level viability. In: Müller GJ, Kessler M (eds) Progress in biomedical optics and imaging: functional monitoring and drug-tissue interaction. Spie Proc Series 4623, pp 187–194Google Scholar
  4. 4.
    Harrison DK, Hawthorn IE (2005) Amputation level viability in critical limb ischaemia: setting new standards. Adv Exp Med Biol 566:325–332PubMedCrossRefGoogle Scholar
  5. 5.
    Harrison DK, Gaylard LG, Singh DB (2007) Thermographic imaging for amputation level viability assessment: just a pretty picture or a quantitative tool? Thermology Int 17:79–80Google Scholar
  6. 6.
    Caddick J, Raine C, Harrison D et al (2006) Lightguide spectrophotometry to monitor free TRAM flaps. Adv Exp Med Biol 578:351–356PubMedCrossRefGoogle Scholar
  7. 7.
    Harrison DK, Evans SD, Abbot NC et al (1992) Spectrophotometric measurements of haemoglobin saturation and concentration in skin during the tuberculin reaction in normal human subjects. Clin Phys Physiol Meas 13:349–363PubMedCrossRefGoogle Scholar
  8. 8.
    Hopf HW, Hunt TK, West JM et al (1997) Wound tissue oxygen tension predicts the risk of wound infection in surgical patients. Arch Surg 132:997–1004PubMedCrossRefGoogle Scholar
  9. 9.
    Ives CL, Harrison DK, Stansby G (2006) Prediction of surgical site infections using spectrophotometry: preliminary results. Adv Exp Med Biol 578:149–154PubMedCrossRefGoogle Scholar
  10. 10.
    Ives CL, Harrison DK, Stansby G (2007) Tissue oxygen saturation, measured by near-infrared spectroscopy, and its relationship to surgical-site infections. Br J Surg 94:87–91PubMedCrossRefGoogle Scholar
  11. 11.
    Singh DB, Stansby G, Bain I, Harrison DK (2009) Intraoperative measurement of colonic oxygenation during bowel resection. Adv Exp Med Biol 645:261–266PubMedCrossRefGoogle Scholar
  12. 12.
    Santora RJ, Moore FA (2009) Monitoring trauma and intensive care unit resuscitation with tissue hemoglobin oxygen saturation. Crit Care 13(Suppl 5):S10PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Institute of Cellular MedicineNewcastle UniversityNewcastle upon TyneUK

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