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Regulation of Vasculogenesis and Angiogenesis

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Coronary Heart Disease

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Abstract

This chapter covers the two major processes involved in the development of blood vessels in embryos and adults: vasculogenesis and angiogenesis, respectively. Vasculogenesis refers to the de novo formation of blood vessels from endothelial progenitors or angioblasts and was believed to be restricted to embryogenesis. The dogma that postnatal neovascularization resulted exclusively from angiogenesis – the proliferation, migration, and remodeling from preexisting blood vessels – was challenged in 1997 with the identification of adult circulating endothelial progenitor cells (EPCs). These findings have important implications not only for a better understanding of the vascular system but also for regenerative medicine since these circulating endothelial progenitors could potentially be useful in the treatment of ischemic conditions.

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Authors and Affiliations

  1. Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, MN, USA

    Rita C. R. Perlingeiro PhD, MSc, BSc

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  1. Rita C. R. Perlingeiro PhD, MSc, BSc
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Correspondence to Rita C. R. Perlingeiro PhD, MSc, BSc .

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    Zeev Vlodaver

  2. University of Minnesota, Delaware Street S.E. 420, Minneapolis, 55455, Minnesota, USA

    Robert F. Wilson

  3. 4-112 Nils Hasselmo Hall, University of Minnesota, Church Street S.E. 312, Minneapolis, 55455, Minnesota, USA

    Daniel J. Garry

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Perlingeiro, R.C.R. (2012). Regulation of Vasculogenesis and Angiogenesis. In: Vlodaver, Z., Wilson, R., Garry, D. (eds) Coronary Heart Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-1475-9_14

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