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Cancer Stem Cells and Tumor Dormancy

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Systems Biology of Tumor Dormancy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 734))

Abstract

The cancer stem cell hypothesis postulates that only a subpopulation of cancer cells in a tumor is capable of initiating, sustaining, and reinitiating tumors, while the bulk of the population comprises non-stem cancer cells that lack tumor initiation potential. The interactions of these two phenotypically distinct populations can provoke various nonlinear growth kinetics in the emerging tumor. An environmentally independent, intrinsic dormant state is an inevitable early tumor progression bottleneck within a range of biologically realistic cell kinetic parameters. In certain conditions, cell kinetics can combine to enable escape to tumor progression, yielding morphologically distinct self-metastatic expansion of multiple self-limiting tumor clones.

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Acknowledgments

This project was supported by the AACR Centennial Postdoctoral Fellowship in Cancer Research 08-40-02-ENDE and the National Cancer Institute under Award Number U54CA149233 (to L. Hlatky). The content is solely the responsibility of the author and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.

I would like to thank Lynn Hlatky and Philip Hahnfeldt for their mentorship, vision, and contribution to the work discussed and reviewed in this chapter. I would also like to thank Jan Poleszczuk for help with Fig. 4.7, and Charles Morton for critical reading of the manuscript.

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  1. Center of Cancer Systems Biology, Steward Research & Specialty Projects Corp., St. Elizabeth’s Medical Center, Tufts University School of Medicine, 736 Cambridge St., Boston, MA, 02135, USA

    Heiko Enderling PhD

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Correspondence to Heiko Enderling PhD .

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Editors and Affiliations

  1. St. Elizabeth's Medical Center, Tufts University School of Medicine, 145 Harrison Avenue, Boston, 02135, Massachusetts, USA

    Heiko Enderling

  2. , Center of Cancer Systems Biology, Tufts University School of Medicine, 736 Cambridge Street, Boston, 02135, Massachusetts, USA

    Nava Almog

  3. , Center of Cancer Systems Biology, Tufts University School of Medicine, 736 Cambridge Street, Boston, 02135, Massachusetts, USA

    Lynn Hlatky

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Enderling, H. (2013). Cancer Stem Cells and Tumor Dormancy. In: Enderling, H., Almog, N., Hlatky, L. (eds) Systems Biology of Tumor Dormancy. Advances in Experimental Medicine and Biology, vol 734. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1445-2_4

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