Efflux-Mediated Antimicrobial Resistance

  • Keith Poole


Efflux, or the energy-dependent export or exclusion of antimicrobials from bacterial cells was first reported in the early 1980s and is now recognized as an increasingly important determinant of resistance in bacterial pathogens [275, 276]. Bacterial efflux systems capable of accommodating antimicrobials generally fall into five classes: (1) the major facilitator (MF) superfamily, (2) the ATP-binding cassette (ABC) family, (3) the resistance-nodulation-division (RND) family, (4) the small multidrug resistance (SMR) family [a member of the much larger drug/metabolite transporter (DMT) superfamily] and (5) the multidrug and toxic compound extrusion (MATE) family [289].


Antimicrobial Resistance Efflux System Macrolide Resistance Efflux Mechanism Aminoglycoside Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Microbiology and ImmunologyQueen’s UniversityKingstonCanada

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