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Efflux-Mediated Antimicrobial Resistance

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Antibiotic Discovery and Development

Abstract

Efflux, or the energy-dependent export or exclusion of antimicrobials from bacterial cells was first reported in the early 1980s and is now recognized as an increasingly important determinant of resistance in bacterial pathogens [275, 276]. Bacterial efflux systems capable of accommodating antimicrobials generally fall into five classes: (1) the major facilitator (MF) superfamily, (2) the ATP-binding cassette (ABC) family, (3) the resistance-nodulation-division (RND) family, (4) the small multidrug resistance (SMR) family [a member of the much larger drug/metabolite transporter (DMT) superfamily] and (5) the multidrug and toxic compound extrusion (MATE) family [289].

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  1. Department of Microbiology and Immunology, Queen’s University, Kingston, ON, K7L 3 N6, Canada

    Keith Poole

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    Thomas J. Dougherty

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    Michael J. Pucci

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Poole, K. (2012). Efflux-Mediated Antimicrobial Resistance. In: Dougherty, T., Pucci, M. (eds) Antibiotic Discovery and Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-1400-1_10

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