Abstract
Thyroid disorders are common in pregnancy. Both hyperthyroidism and hypothyroidism need to be monitored closely during pregnancy and the postpartum period. Etiology of thyrotoxicosis in pregnancy includes HCG-mediated thyrotoxicosis, Graves’ disease (i.e., autoimmune), and postpartum thyroiditis.
Antithyroid drugs can be prescribed for Graves’ disease. Fetal thyrotoxicosis, goiter, and even fetal hypothyroidism (i.e., secondary to overtreatment) are potential complications. In patients with hypothyroidism, thyroid hormone replacement may need to be increased by as much as 25–50 % during the course of pregnancy.
Both diffuse and nodular growth of the thyroid gland can occur in pregnancy; however, thyroid cancer and compressive symptoms are rare.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Goodwin TM, Montoro M, Mestman JH. Transient hyperthyroidism and hyperemesis gravidarum: clinical aspects. Am J Obstet Gynecol. 1992;167:648–52.
Patil-Sisodia K, Mestman JH. Graves hyperthyroidism and pregnancy: a clinical update. Endocr Pract. 2010;16:118–29.
Stagnaro-Green A. Postpartum thyroiditis. Best Pract Res Clin Endocrinol Metab. 2004;18:303–16.
Allan WC, Haddow JE, Palomaki GE, Williams JR, Mitchell ML, Hermos RJ, Faix JD, Klein RZ. Maternal thyroid deficiency and pregnancy complications: implications for population screening. J Med Screen. 2000;7:127–30.
Struve CW, Haupt S, Ohlen S. Influence of frequency of previous pregnancies on the prevalence of thyroid nodules in women without clinical evidence of thyroid disease. Thyroid. 1993;3:7–9.
Smith LH, Danielsen B, Allen ME, Cress R. Cancer associated with obstetric delivery: results of linkage with the California cancer registry. Am J Obstet Gynecol. 2003;189:1128–35.
Keely E, Barbour L. Thyroid Disorders. In: Rosene-Montella K, Keely E, Barbour LA, Lee R, editors. Medical care of the pregnant patient. Philadelphia: Sheridan Press; 2008. p. 253–70.
Stagnaro-Green A, et al. Guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21:1081.
Goodwin TM, Hershman JM. Hyperthyroidism due to inappropriate production of human chorionic gonadotropin. Clin Obstet Gynecol. 1997;40:32–44.
Mandel SJ, Cooper DS. The use of antithyroid drugs in pregnancy and lactation. J Clin Endocrinol Metab. 2001;86:2354–9.
Hamburger JI. Diagnosis and management of Graves’ disease in pregnancy. Thyroid. 1992;2:219–24.
Zimmerman D. Fetal and neonatal hyperthyroidism. Thyroid. 1999;9:727–33.
Stagnaro-Green A. Clinical review 152: postpartum thyroiditis. J Clin Endocrinol Metab. 2002;87:4042–7.
Abalovich M, Gutierrez S, Alcaraz G, Maccallini G, Garcia A, Levalle O. Overt and subclinical hypothyroidism complicating pregnancy. Thyroid. 2002;12:63–8.
Negro R, Formoso G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. J Clin Endocrinol Metab. 2006;91:2587–91.
Cooper DS, Doherty GM, Haugen BR, et al. Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. The American thyroid association (ATA) guidelines taskforce on thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19(11):1167–281.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this chapter
Cite this chapter
Whelan, M., Gopalakrishnan, G. (2015). Thyroid Disease. In: Rosene-Montella, K. (eds) Medical Management of the Pregnant Patient. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1244-1_14
Download citation
DOI: https://doi.org/10.1007/978-1-4614-1244-1_14
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-1243-4
Online ISBN: 978-1-4614-1244-1
eBook Packages: MedicineMedicine (R0)