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Signaling Pathways in Cancer Pathogenesis and Therapy pp 55–79Cite as

The Hedgehog Signaling Pathway in Cancer Pathogenesis and Therapy

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Abstract

Elucidation of the hedgehog signaling pathway in Drosophila represented a series of beautiful studies in developmental biology. As is often true in science, research in one area can have a significant impact in seemingly unrelated areas. Starting with studies on genetic predisposition to cancer, it soon became clear that mutations affecting the hedgehog pathway occur in a broad spectrum of human cancers. Understanding the biology of this pathway and its role in cancer pathogenesis has also provided significant opportunities for the development of novel-targeted therapies for a variety of cancers.

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  1. Infinity Pharmaceuticals, Inc., Cambridge, MA, 02139, USA

    Margaret A. Read & Vito J. Palombella

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  1. Margaret A. Read
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  2. Vito J. Palombella
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Correspondence to Margaret A. Read .

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  1. Dana-Farber Cancer Institute, Dept. Medical Oncology, Harvard Medical School, Binney St. 44, Boston, 02115, Massachusetts, USA

    David A. Frank

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Read, M.A., Palombella, V.J. (2012). The Hedgehog Signaling Pathway in Cancer Pathogenesis and Therapy. In: Frank, D. (eds) Signaling Pathways in Cancer Pathogenesis and Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1216-8_5

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