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SLE Epidemiology: Epidemiologic Subtypes and Risk Factors for Development

  • Julia F. Simard
  • Karen H. Costenbader
Chapter

Abstract

While the etiology of systemic lupus erythematosus (SLE) is still enigmatic, epidemiologic research is continuously informing our understanding, with new insights into environmental risk factors and gene–environment interactions that play a role in disease susceptibility. SLE is a heterogeneous multisystem autoimmune disorder characterized by organ system manifestations which vary over time and autoantibodies that target mainly intracellular constituents. Antinuclear antibodies (ANA) are observed in over 95% of patients, while other characteristic autoantibodies [anti-double-stranded DNA (anti-dsDNA), anti-Smith (anti-Sm), anti-Ro, and anti-La antibodies] are less common. These autoantibodies have been detected years prior to first symptoms of SLE and are responsible for certain disease manifestations such as photosensitive rashes, cytopenias, thromboses, and glomerulonephritis.

Keywords

Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Systemic Lupus Erythematosus Disease Activity Undifferentiated Connective Tissue Disease Silicone Breast Implant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Clinical Epidemiology UnitT2, Karolinska University HospitalStockholmSweden
  2. 2.Lupus CenterBrigham and Women’s HospitalBostonUSA
  3. 3.Harvard Medical SchoolBostonUSA

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