SLE Epidemiology: Epidemiologic Subtypes and Risk Factors for Development
While the etiology of systemic lupus erythematosus (SLE) is still enigmatic, epidemiologic research is continuously informing our understanding, with new insights into environmental risk factors and gene–environment interactions that play a role in disease susceptibility. SLE is a heterogeneous multisystem autoimmune disorder characterized by organ system manifestations which vary over time and autoantibodies that target mainly intracellular constituents. Antinuclear antibodies (ANA) are observed in over 95% of patients, while other characteristic autoantibodies [anti-double-stranded DNA (anti-dsDNA), anti-Smith (anti-Sm), anti-Ro, and anti-La antibodies] are less common. These autoantibodies have been detected years prior to first symptoms of SLE and are responsible for certain disease manifestations such as photosensitive rashes, cytopenias, thromboses, and glomerulonephritis.
KeywordsArthritis Mercury Petroleum Corticosteroid Testosterone
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