Optimizing the Formulation of Poorly Water-Soluble Drugs

Chapter
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 3)

Abstract

With as high as 60% of drugs in company pipelines exhibiting poor aqueous solubility, the ability to successfully develop a poorly water-soluble drug has become essential. Gaining a detailed understanding of a compound through preformulation studies can be especially challenging for poorly water-soluble drugs limiting their development. Therefore, this chapter focuses on the application of preformulation studies essential in understanding a poorly water-soluble drug, including solubility studies, solid-state characterization of the active ingredient and formulations thereof, and in vitro and in vivo testing of the lead formulations.

Keywords

Chitosan Paclitaxel Lactose Ibuprofen Gallium 

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Copyright information

© American Association of Pharmaceutical Scientists 2012

Authors and Affiliations

  1. 1.Division of Pharmaceutics, College of PharmacyThe University of Texas at AustinAustinUSA

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