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Formulating Poorly Water Soluble Drugs pp 443–500Cite as

Pharmaceutical Cryogenic Technologies

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Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 3))

Abstract

Poor bioavailability associated with poorly water-soluble compounds remains a challenging issue in drug development. Particle engineering may be used to improve the physicochemical properties of poorly water-soluble compounds, thereby enhancing the bioavailability. Cryogenic technologies, including spray freeze drying (SFD), spray freezing into liquid (SFL), and thin film freezing (TFF), are “bottom-up” precipitation processes to generate amorphous nanostructured aggregates with significantly enlarged surface area, higher dissolution rates, and supersaturation, via rapidly inducing nucleation followed by particle growth arrest through stabilization via polymers and solidification of the solvent. This chapter provides detailed description of each cryogenic process, formulation guidelines, and characterization analyses. Finally, examples of cryogenically engineered drug compositions with improved in vitro and in vivo macroscopic performance are provided to illustrate the potential benefits of cryogenic technologies, especially TFF.

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Authors and Affiliations

  1. Enavail, LLC., 11412 Bee Caves Road, Suite 300, Austin, TX, 78738, USA

    Wei Yang & Donald E. Owens III

  2. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, 2409 West University Avenue, PHR 4.214, Austin, TX, 78712, USA

    Robert O. Williams III

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  1. Wei Yang
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  2. Donald E. Owens III
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  3. Robert O. Williams III
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Correspondence to Wei Yang .

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Editors and Affiliations

  1. , Division of Pharmacy, University of Texas at Austin, Mailstop A1920, Austin, 78712, USA

    Robert O. Williams III

  2. College of Pharmacy, Drug Dynamics Institute, University of Texas, Austin, 78712, Texas, USA

    Alan B. Watts

  3. , Pharmaceutical and Analytical R&D, Hoffmann-La Roche, Inc., Kingsland St 340, Nutley, 07110, USA

    Dave A. Miller

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Yang, W., Owens, D.E., Williams, R.O. (2012). Pharmaceutical Cryogenic Technologies. In: Williams III, R., Watts, A., Miller, D. (eds) Formulating Poorly Water Soluble Drugs. AAPS Advances in the Pharmaceutical Sciences Series, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1144-4_11

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