Diversified Classes of Enzyme Modulators
Enzymatic catalyses are mediated by functional groups present in amino acid side chains. The amino acid side chains of enzymes that are frequently directly involved in enzyme catalytic processes include histidine, serine, cystein, lysine, glutamate, and aspartate. The active site of an enzyme is usually larger than the substrate, since in most cases the substrate is partially surrounded by the active site. The structure of an enzyme is required to stabilize the conformation of the active site for achieving enzymatic function.
KeywordsPhenol Tyrosine Glutathione Superoxide Cysteine
- Dinkova-Kostova AT, Abeygunawardana C, Talalay P (1998) Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers. J Med Chem 41:5287–5296PubMedCrossRefGoogle Scholar