Abstract
Phase II detoxification enzymes play an important role in antioxidant defense by eliminating electrophilic intermediates and reactive oxygen species. This is done by up regulating the mechanisms that keep reactive intermediates at a minimum level and improving the mechanisms that scavenge oxidants. The ability of individuals to remove chemically active metabolites from the body plays a crucial role in reducing the risk of a variety of disease conditions. Oxidative stress occurs when reactive electrophilic species are neither readily detoxified by phase II enzymes nor compensated for by the body’s antioxidant defense systems. It has been reported that oxidative stress causes inflammation and damages to cells and tissues, which could attribute to many disease conditions (e.g., cancer, atherosclerosis, heart disease, chronic fatigue syndrome, and Alzheimer). Diseases associated with aging also have underlying oxidative stress and inflammatory components.
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Chen, CH. (2012). Induction of Enzymes for Health Benefits. In: Activation and Detoxification Enzymes. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1049-2_12
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DOI: https://doi.org/10.1007/978-1-4614-1049-2_12
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