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A Ribosomal Perspective on the Mechanism of Selenocysteine Incorporation

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Abstract

Selenocysteine (Sec) is cotranslationally inserted into polypeptides during the elongation phase of protein synthesis in response to specific UGA codons. As UGA normally signals translation termination, the Sec incorporation complex is required to modify the canonical translation machinery. Thus, a thorough understanding of the Sec incorporation mechanism necessitates careful consideration of the intricacies of general translation, specifically during the elongation phase. Here, we consider the current body of evidence that supports a key role for the ribosome in regulating the process of Sec incorporation.

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Acknowledgements

This work was supported by National Institutes of Health grants to PRC and a National Research Service Award to KC.

Author information

Authors and Affiliations

  1. Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA

    Kelvin Caban & Paul R. Copeland

Authors
  1. Kelvin Caban
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  2. Paul R. Copeland
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Corresponding author

Correspondence to Paul R. Copeland .

Editor information

Editors and Affiliations

  1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Dolph L. Hatfield

  2. University of Hawaii, Monoa, Dole Street 2444, Honolulu, 96822, Hawaii, USA

    Marla J. Berry

  3. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Avenue Louis Pasteur 77, Boston, 02115, USA

    Vadim N. Gladyshev

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Caban, K., Copeland, P.R. (2011). A Ribosomal Perspective on the Mechanism of Selenocysteine Incorporation. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_5

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