Selenium pp 561-572 | Cite as

Mouse Models that Target Removal or Overexpression of the Selenocysteine tRNA[Ser]Sec Gene to Elucidate the Role of Selenoproteins in Health and Development

  • Bradley A. Carlson
  • Min-Hyuk Yoo
  • Petra A. Tsuji
  • Ryuta Tobe
  • Salvador Naranjo-Suarez
  • Fang Chen
  • Lionel Feigenbaum
  • Lino Tessarollo
  • Byeong Jae Lee
  • Vadim N. Gladyshev
  • Dolph L. Hatfield


Several mouse models targeting the selenocysteine (Sec) tRNA[Ser]Sec gene for removal or overexpression have been generated and they include: (1) mice carrying a conditional knockout of the Sec tRNA gene; (2) transgenic mice encoding wild type or mutant Sec tRNA transgenes; and (3) conditional knockout/transgenic or standard knockout/transgenic mice carrying wild type or mutant Sec tRNA transgenes. These models have provided powerful tools for elucidating the roles of selenoproteins in development and health.


Hair Follicle Heart Disease Prevention Selenoprotein Gene Affected Mouse Selenoprotein Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the National Institutes of Health NCI Intramural Research Program and the Center for Cancer Research (to DLH) and by National Institutes of Health Grants (to VNG).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Bradley A. Carlson
    • 1
  • Min-Hyuk Yoo
    • 1
  • Petra A. Tsuji
    • 1
    • 2
  • Ryuta Tobe
    • 1
  • Salvador Naranjo-Suarez
    • 1
  • Fang Chen
    • 1
  • Lionel Feigenbaum
    • 3
  • Lino Tessarollo
    • 4
  • Byeong Jae Lee
    • 5
  • Vadim N. Gladyshev
    • 6
  • Dolph L. Hatfield
    • 1
  1. 1.Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer ResearchNational Cancer Institute, National Institutes of HealthBethesdaUSA
  2. 2.Cancer Prevention Fellowship ProgramNational Cancer Institute, National Institutes of HealthBethesdaUSA
  3. 3.Laboratory Animal Science ProgramScience Applications International CorporationFrederickUSA
  4. 4.Neural Development Group, Mouse Cancer Genetics Program, Center for Cancer ResearchNational Cancer InstituteFrederickUSA
  5. 5.Department of Biological Sciences, Interdisciplinary Program for BioinformaticsSeoul National UniversitySeoulSouth Korea
  6. 6.Division of Genetics, Department of MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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