Selenium pp 561-572 | Cite as

Mouse Models that Target Removal or Overexpression of the Selenocysteine tRNA[Ser]Sec Gene to Elucidate the Role of Selenoproteins in Health and Development

  • Bradley A. Carlson
  • Min-Hyuk Yoo
  • Petra A. Tsuji
  • Ryuta Tobe
  • Salvador Naranjo-Suarez
  • Fang Chen
  • Lionel Feigenbaum
  • Lino Tessarollo
  • Byeong Jae Lee
  • Vadim N. Gladyshev
  • Dolph L. Hatfield
Chapter

Abstract

Several mouse models targeting the selenocysteine (Sec) tRNA[Ser]Sec gene for removal or overexpression have been generated and they include: (1) mice carrying a conditional knockout of the Sec tRNA gene; (2) transgenic mice encoding wild type or mutant Sec tRNA transgenes; and (3) conditional knockout/transgenic or standard knockout/transgenic mice carrying wild type or mutant Sec tRNA transgenes. These models have provided powerful tools for elucidating the roles of selenoproteins in development and health.

Keywords

Migration Hydrogen Peroxide Codon Glutathione Cysteine 

Notes

Acknowledgements

This work was supported by the National Institutes of Health NCI Intramural Research Program and the Center for Cancer Research (to DLH) and by National Institutes of Health Grants (to VNG).

References

  1. 1.
    Hatfield DL, Berry MJ, Gladyshev VN (2006) Selenium: its molecular biology and role in human health. Springer Science+Business Media LLC, New YorkGoogle Scholar
  2. 2.
    Birringer M, Pilawa S, Flohé L (2002) Nat Prod Rep 19:693PubMedCrossRefGoogle Scholar
  3. 3.
    Hatfield DL, Gladyshev VN (2002) Mol Cell Biol 22:3565PubMedCrossRefGoogle Scholar
  4. 4.
    Stadtman TC (2002) Annu Rev Biochem 71:1PubMedCrossRefGoogle Scholar
  5. 5.
    Xu XM, Carlson BA, Mix H et al (2006) PLoS Biol 5:e4CrossRefGoogle Scholar
  6. 6.
    Yuan J, Palioura S, Salazar JC et al (2006) Proc Natl Acad Sci USA 103:18923PubMedCrossRefGoogle Scholar
  7. 7.
    Hatfield DL, Choi IS, Ohama T et al (1994) Selenium in biology and human health. In: Burk RF (ed) Springer, New York, p 25Google Scholar
  8. 8.
    Kryukov GV, Castellano S, Novoselov SV et al (2003) Science 300:1439PubMedCrossRefGoogle Scholar
  9. 9.
    Moustafa ME, Carlson BA, El-Saadani MA et al (2001) Mol Cell Biol 21:3840PubMedCrossRefGoogle Scholar
  10. 10.
    Carlson BA, Xu XM, Gladyshev VN et al (2005) J Biol Chem 280:5542PubMedCrossRefGoogle Scholar
  11. 11.
    Diamond AM, Choi IS, Crain PF et al (1993) J Biol Chem 268:14215PubMedGoogle Scholar
  12. 12.
    Hatfield DL, Carlson BA, Xu XM et al (2006) Prog Nucleic Acid Res Mol Biol 81:97PubMedCrossRefGoogle Scholar
  13. 13.
    Kim LK, Matsufuji T, Matsufuji S et al (2000) RNA 6:1306PubMedCrossRefGoogle Scholar
  14. 14.
    Carlson BA, Moustafa ME, Sengupta A et al (2007) J Biol Chem 282:32591PubMedCrossRefGoogle Scholar
  15. 15.
    Martin GW 3rd, Harney JW, Berry MJ (1996) RNA 2:171PubMedGoogle Scholar
  16. 16.
    Irons R, Carlson BA, Hatfield DL et al (2006) J Nutr 136:1311PubMedGoogle Scholar
  17. 17.
    Diwadkar-Navsariwala V, Prins GS, Swanson SM et al (2006) Proc Natl Acad Sci USA 103:8179PubMedCrossRefGoogle Scholar
  18. 18.
    Bosl MR, Takaku K, Oshima M et al (1997) Proc Natl Acad Sci USA 94:5531PubMedCrossRefGoogle Scholar
  19. 19.
    Kumaraswamy E, Carlson BA, Morgan F et al (2003) Mol Cell Biol 23:1477PubMedCrossRefGoogle Scholar
  20. 20.
    Hoffmann PR, Berry MJ (2008) Mol Nutr Food Res 52:1273PubMedCrossRefGoogle Scholar
  21. 21.
    Shrimali RK, Irons RD, Carlson BA et al (2008) J Biol Chem 283:20818CrossRefGoogle Scholar
  22. 22.
    Suzuki T, Kelly VP, Motohashi H et al (2008) J Biol Chem 283:2021PubMedCrossRefGoogle Scholar
  23. 23.
    Carlson BA, Yoo MY, Sano Y et al (2009) BMC Immunol 10:57PubMedCrossRefGoogle Scholar
  24. 24.
    Carlson BA, Yoo MY, Shrimali RK et al (2010) Proc Nutr Soc 69:300PubMedCrossRefGoogle Scholar
  25. 25.
    Burke MP, Opeskin K (2002) Med Sci Law 42:10PubMedGoogle Scholar
  26. 26.
    Shrimali RK, Weaver JA, Miller GF et al (2007) Neuromuscul Disord 17:135PubMedCrossRefGoogle Scholar
  27. 27.
    Schweizer U, Bräuer AU, Köhrle J et al (2004) Brain Res Brain Res Rev 45:164PubMedCrossRefGoogle Scholar
  28. 28.
    Wirth EK, Conrad M, Winterer J et al (2010) FASEB J 24:844PubMedCrossRefGoogle Scholar
  29. 29.
    McKenzie RC (2000) Clin Experi Derma 25:631CrossRefGoogle Scholar
  30. 30.
    Sengupta A, Lichti UF, Carlson BA et al (2010) PLoS One 5:e12249PubMedCrossRefGoogle Scholar
  31. 31.
    Carlson BA, Novoselov SV, Kumaraswamy E et al (2004) J Biol Chem 279:8011PubMedCrossRefGoogle Scholar
  32. 32.
    Kelly VP, Suzuki T, Nakajima O et al (2005) Mol Cell Biol 25:3658PubMedCrossRefGoogle Scholar
  33. 33.
    Carlson BA, Schweizer U, Perella C et al (2009) Biochem J 418:61PubMedCrossRefGoogle Scholar
  34. 34.
    Hatfield D, Gladyshev V, Park JM et al (1999) Comprehensive natural products chemistry. In: Kelly JW (ed) Elsevier Science, Oxford, p 353Google Scholar
  35. 35.
    Schomburg L, Schweizer U, Holtmann B et al (2003) Biochem J 370:397PubMedCrossRefGoogle Scholar
  36. 36.
    Conrad M, Schweizer U (2010) Antioxid Redox Signal 12:851PubMedCrossRefGoogle Scholar
  37. 37.
    Reeves MA, Hoffmann PR (2009) Cell Mol Life Sci 66:2457PubMedCrossRefGoogle Scholar
  38. 38.
    Brigelius-Flohé R (2008) Chem Biodivers 5:389PubMedCrossRefGoogle Scholar
  39. 39.
    Hornberger TA, McLoughlin TJ, Leszczynski JK et al (2003) J Nutr 133:3091PubMedGoogle Scholar
  40. 40.
    Sheridan PA, Zhong N, Carlson BA et al (2007) J Nutr 137:1466PubMedGoogle Scholar
  41. 41.
    Baliga MS, Diwadkar-Navsariwala V, Koh T et al (2008) Mol Nutr Food Res 52:1300PubMedCrossRefGoogle Scholar
  42. 42.
    Blauwkamp MN, Yu J, Schin MA et al (2008) BMC Nephrol 9:7PubMedCrossRefGoogle Scholar
  43. 43.
    Downey CM, Horton CR, Carlson BA et al (2009) PLoS Genet 5:e1000616PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Bradley A. Carlson
    • 1
  • Min-Hyuk Yoo
    • 1
  • Petra A. Tsuji
    • 1
    • 2
  • Ryuta Tobe
    • 1
  • Salvador Naranjo-Suarez
    • 1
  • Fang Chen
    • 1
  • Lionel Feigenbaum
    • 3
  • Lino Tessarollo
    • 4
  • Byeong Jae Lee
    • 5
  • Vadim N. Gladyshev
    • 6
  • Dolph L. Hatfield
    • 1
  1. 1.Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer ResearchNational Cancer Institute, National Institutes of HealthBethesdaUSA
  2. 2.Cancer Prevention Fellowship ProgramNational Cancer Institute, National Institutes of HealthBethesdaUSA
  3. 3.Laboratory Animal Science ProgramScience Applications International CorporationFrederickUSA
  4. 4.Neural Development Group, Mouse Cancer Genetics Program, Center for Cancer ResearchNational Cancer InstituteFrederickUSA
  5. 5.Department of Biological Sciences, Interdisciplinary Program for BioinformaticsSeoul National UniversitySeoulSouth Korea
  6. 6.Division of Genetics, Department of MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

Personalised recommendations