Selenium pp 531-544 | Cite as

Selenium and Adverse Health Conditions of Human Pregnancy

  • Margaret P. RaymanEmail author


There is evidence that selenium affects a number of adverse pregnancy health conditions. While higher selenium status has been associated with a lower risk of miscarriage and preterm birth, the level of evidence is stronger for a benefit of higher selenium intake/status in preeclampsia and autoimmune thyroid disease characterized by raised thyroid peroxidase antibodies. The ability of selenium to reduce oxidative stress, endoplasmic reticulum stress, and inflammation, to protect the endothelium, to control eicosanoid production, to regulate vascular tone, and to reduce infection is likely to be important in the context of these conditions.


Endoplasmic Reticulum Stress Preterm Birth Autoimmune Thyroid Disease Selenium Deficiency Selenium Supplementation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



I gratefully acknowledge helpful collaborations with Prof. Victor Pop and Prof. Chris Redman and financial support from the Wellcome Trust, the Waterloo Foundation, Pharma Nord, and Wassen International.


  1. 1.
    Kasik JW, Rice EJ (1995) Placenta 16:67PubMedCrossRefGoogle Scholar
  2. 2.
    Moses EK, Johnson MP, Tømmerdal L et al (2008) Am J Obstet Gynecol 198:336.e1–5CrossRefGoogle Scholar
  3. 3.
    Duley L (2009) Semin Perinatol 33:130PubMedCrossRefGoogle Scholar
  4. 4.
    Steegers EA, von Dadelszen P, Duvekot JJ et al (2010) Lancet 376:631PubMedCrossRefGoogle Scholar
  5. 5.
    Barker DJ, Osmond C, Golding J et al (1989) BMJ 298:564PubMedCrossRefGoogle Scholar
  6. 6.
    Sattar N, Greer IA (2002) BMJ 325:157PubMedCrossRefGoogle Scholar
  7. 7.
    Redman CW, Sargent IL (2000) Placenta 21:597PubMedCrossRefGoogle Scholar
  8. 8.
    Hubel CA (1999) Proc Soc Exp Biol Med 222:222PubMedCrossRefGoogle Scholar
  9. 9.
    Hung TH, Skepper JN, Charnock-Jones DS et al (2002) Circ Res 90:1274PubMedCrossRefGoogle Scholar
  10. 10.
    Goswami D, Tannetta DS, Magee LA et al (2006) Placenta 27:56PubMedCrossRefGoogle Scholar
  11. 11.
    Redman CW, Sacks GP, Sargent IL (1999) Am J Obstet Gynecol 180:499PubMedCrossRefGoogle Scholar
  12. 12.
    Roberts JM, Taylor RN, Musci TJ et al (1989) Am J Obstet Gynecol 161:1200PubMedGoogle Scholar
  13. 13.
    Levine RJ, Maynard SE, Qian C et al (2004) N Engl J Med 350:672PubMedCrossRefGoogle Scholar
  14. 14.
    Austgulen R, Lien E, Vince G et al (1997) Eur J Obstet Gynecol Reprod Biol 71:53PubMedCrossRefGoogle Scholar
  15. 15.
    Myatt L, Rosenfield R, Eis AL et al (1996) Hypertension 28:488PubMedGoogle Scholar
  16. 16.
    Roggensack AM, Zhang Y, Davidge ST (1999) Hypertension 33:83PubMedGoogle Scholar
  17. 17.
    Chavarría ME, Lara-González L, González-Gleason A et al (2003) Am J Obstet Gynecol 188:986PubMedCrossRefGoogle Scholar
  18. 18.
    Redman CW, Sargent IL (2005) Science 308:1592PubMedCrossRefGoogle Scholar
  19. 19.
    Vanderlelie J, Venardos K, Perkins AV (2004) Reproduction 128:635PubMedCrossRefGoogle Scholar
  20. 20.
    Han L, Zhou S (1994) Chinese Med J 107:870Google Scholar
  21. 21.
    Walsh SW, Wang Y (1993) Am J Obstet Gynecol 169:1456PubMedGoogle Scholar
  22. 22.
    Vanderlelie J, Venardos K, Clifton V et al (2005) Placenta 26:53PubMedCrossRefGoogle Scholar
  23. 23.
    Atamer Y, Koçyigit Y, Yokus B et al (2005) Eur J Obstet Gynecol Reprod Biol 119:60PubMedCrossRefGoogle Scholar
  24. 24.
    Mistry HD, Wilson V, Ramsay MM et al (2008) Hypertension 52:881PubMedCrossRefGoogle Scholar
  25. 25.
    Mistry HD, Kurlak LO, Williams PJ et al (2010) Placenta 31:401PubMedCrossRefGoogle Scholar
  26. 26.
    Rayman MP, Abou-Shakra FR, Ward NI et al (1996) Biol Trace Elem Res 55:9PubMedCrossRefGoogle Scholar
  27. 27.
    Rayman MP, Bode P, Redman CW (2003) Am J Obstet Gynecol 189:1343PubMedCrossRefGoogle Scholar
  28. 28.
    Sattar N, Scott HR, McMillan DC et al (1997) Nutr Cancer 28:308PubMedCrossRefGoogle Scholar
  29. 29.
    Nichol C, Herdman J, Sattar N et al (1998) Clin Chem 44:1764PubMedGoogle Scholar
  30. 30.
    Broome CS, McArdle F, Kyle JA et al (2004) Am J Clin Nutr 80:154PubMedGoogle Scholar
  31. 31.
    Redman CW, Sargent IL (2010) Am J Reprod Immunol 63:534PubMedCrossRefGoogle Scholar
  32. 32.
    Leber A, Zenclussen ML, Teles A et al (2011) Methods Mol Biol 677:397PubMedCrossRefGoogle Scholar
  33. 33.
    Xue H, Wang W, Li Y et al (2010) Endocr J 57:595PubMedCrossRefGoogle Scholar
  34. 34.
    Brigelius-Flohé R, Banning A, Schnurr K (2003) Antioxid Redox Signal 5:205PubMedCrossRefGoogle Scholar
  35. 35.
    Shchedrina VA, Zhang Y, Labunskyy VM et al (2010) Antioxid Redox Signal 12:839PubMedCrossRefGoogle Scholar
  36. 36.
    Stoedter M, Renko K, Hög A et al (2010) Biochem J 429:43PubMedCrossRefGoogle Scholar
  37. 37.
    Lewin MH, Arthur JR, Riemersma RA et al (2002) Biochim Biophys Acta 1593:85PubMedCrossRefGoogle Scholar
  38. 38.
    Miller S, Walker SW, Arthur JR et al (2001) Clin Sci (Lond) 100:543CrossRefGoogle Scholar
  39. 39.
    Thomas JP, Geiger PG, Girotti AW (1993) J Lipid Res 34:479PubMedGoogle Scholar
  40. 40.
    Lu X, Liu SY, Man RY (1994) Cardiovasc Res 28:345PubMedCrossRefGoogle Scholar
  41. 41.
    Arteel GE, Briviba K, Sies H (1999) FEBS Lett 445:226PubMedCrossRefGoogle Scholar
  42. 42.
    Traulsen H, Steinbrenner H, Buchczyk DP et al (2004) Free Radic Res 38:123PubMedCrossRefGoogle Scholar
  43. 43.
    Moschos MP (2000) Cell Mol Life Sci 57:1836PubMedCrossRefGoogle Scholar
  44. 44.
    Sordillo LM, Weaver JA, Cao YZ et al (2005) Prostaglandins Other Lipid Mediat 76:19PubMedCrossRefGoogle Scholar
  45. 45.
    Cao YZ, Reddy CC, Sordillo LM (2000) Free Radic Biol Med 28:381PubMedCrossRefGoogle Scholar
  46. 46.
    Vunta H, Davis F, Palempalli UD et al (2007) J Biol Chem 282:17964PubMedCrossRefGoogle Scholar
  47. 47.
    Vunta H, Belda BJ, Arner RJ et al (2008) Mol Nutr Food Res 52:1316PubMedCrossRefGoogle Scholar
  48. 48.
    Ricote M, Li AC, Willson TM et al (1998) Nature 391:79PubMedCrossRefGoogle Scholar
  49. 49.
    Touyz RM, Schiffrin EL (2006) Vascul Pharmacol 45:19PubMedCrossRefGoogle Scholar
  50. 50.
    Bainbridge SA, Smith GN (2005) Free Radic Biol Med 38:979PubMedCrossRefGoogle Scholar
  51. 51.
    Kirkby KA, Adin CA (2006) Am J Physiol Renal Physiol 290:F563PubMedCrossRefGoogle Scholar
  52. 52.
    Trigona WL, Mullarky IK, Cao Y, Sordillo LM et al (2006) Biochem J 394:207PubMedCrossRefGoogle Scholar
  53. 53.
    Ejima K, Layne MD, Carvajal IM et al (2002) Antioxid Redox Signal 4:569PubMedCrossRefGoogle Scholar
  54. 54.
    Krönke G, Kadl A, Ikonomu E et al (2007) Arterioscler Thromb Vasc Biol 27:1276PubMedCrossRefGoogle Scholar
  55. 55.
    Lee TS, Tsai HL, Chau LY (2003) J Biol Chem 278:19325PubMedCrossRefGoogle Scholar
  56. 56.
    Gao Y, Hannan NR, Wanyonyi S et al (2006) Cytokine 33:246PubMedCrossRefGoogle Scholar
  57. 57.
    Rayman MP (2010) Chapter 19. In: Milner JA, Romagnolo DF (eds) Bioactive compounds and cancer, Humana Press/Springer, New YorkGoogle Scholar
  58. 58.
    Shah TJ, Walsh SW (2007) Am J Obstet Gynecol 196:48.e1CrossRefGoogle Scholar
  59. 59.
    Jahnova E, Horvathova M, Gazdik F et al (2002) Bratisl Lek Listy 103:12PubMedGoogle Scholar
  60. 60.
    Zhang F, Wu Y, Hargrove JL et al (2002) Atherosclerosis 161:381PubMedCrossRefGoogle Scholar
  61. 61.
    Banning A, Schnurr K, Bol GF et al (2004) Free Radic Biol Med 36:135PubMedCrossRefGoogle Scholar
  62. 62.
    Maddox JF, Aherne KM, Reddy CC et al (1999) J Leukoc Biol 65:658PubMedGoogle Scholar
  63. 63.
    Ahmed A, Rahman M, Zhang X et al (2000) Mol Med 6:391PubMedGoogle Scholar
  64. 64.
    Cudmore M, Ahmad S, Al-Ani B et al (2007) Circulation 115:1789PubMedCrossRefGoogle Scholar
  65. 65.
    Zenclussen ML, Anegon I, Bertoja AZ et al (2006) J Reprod Immunol 69:35PubMedCrossRefGoogle Scholar
  66. 66.
    Curran JE, Jowett JB, Elliott KS et al (2005) Nat Genet 37:1234PubMedCrossRefGoogle Scholar
  67. 67.
    Allison JL, Schust DJ (2009) Curr Opin Endocrinol Diabetes Obes 16:446PubMedCrossRefGoogle Scholar
  68. 68.
    Underwood EJ (1977) Trace elements in human and animal nutrition, 4th edn. Academic Press, New YorkGoogle Scholar
  69. 69.
    Barrington JW, Lindsay P, James D et al (1996) Br J Obs Gynaecol 103:130CrossRefGoogle Scholar
  70. 70.
    Barrington JW, Taylor M, Smith S et al (1997) J Obs Gyn 17:199CrossRefGoogle Scholar
  71. 71.
    Al-Kunani AS, Knight R, Haswell SJ et al (2001) BJOG 108:1094PubMedCrossRefGoogle Scholar
  72. 72.
    Kumar KS, Kumar A, Prakash S et al (2002) J Obstet Gynaecol 22:181PubMedCrossRefGoogle Scholar
  73. 73.
    Zachara BA, Dobrzyński W, Trafikowska U et al (2001) BJOG 108:244PubMedCrossRefGoogle Scholar
  74. 74.
    Nicoll AE, Norman J, MacPherson A et al (1999) BJOG 106:1188CrossRefGoogle Scholar
  75. 75.
    Butler JA, Whanger PD, Tripp MJ (1982) Am J Clin Nutr 36:15PubMedGoogle Scholar
  76. 76.
    Christiansen OB, Nielsen HS, Kolte AM (2006) Semin Fetal Neonatal Med 11:302PubMedCrossRefGoogle Scholar
  77. 77.
    Hesse-Bähr K, Dreher I, Köhrle J (2000) Biofactors 11:83PubMedCrossRefGoogle Scholar
  78. 78.
    Goldenberg RL, Culhane JF, Iams JD et al (2008) Lancet 371:75PubMedCrossRefGoogle Scholar
  79. 79.
    Saigal S, Doyle LW (2008) Lancet 371:261PubMedCrossRefGoogle Scholar
  80. 80.
    Rayman MP, Wijnen H, Vader H et al (2011) CMAJ 14 Feb (Epub ahead of print)Google Scholar
  81. 81.
    Tara F, Rayman MP, Boskabadi H et al (2010) Obstet Gynaecol 30:30CrossRefGoogle Scholar
  82. 82.
    van den Brandt PA, Goldbohm RA, van’t Veer P et al (1993) Cancer Epidemiol Biomarkers Prev 2:107PubMedGoogle Scholar
  83. 83.
    Romero R, Espinoza J, Gonçalves LF et al (2006) Semin Fetal Neonatal Med 11:317PubMedCrossRefGoogle Scholar
  84. 84.
    Cleary-Goldman J, Malone FD, Lambert-Messerlian G et al (2008) Obstet Gynecol 112:85PubMedCrossRefGoogle Scholar
  85. 85.
    Parry S, Strauss JF 3rd (1998) N Engl J Med 338:663PubMedCrossRefGoogle Scholar
  86.  86.
    Rayman MP (2000) Lancet 356:233PubMedCrossRefGoogle Scholar
  87.  87.
    Holst D, Garnier Y (2008) Eur J Obstet Gynecol Reprod Biol 141:3PubMedCrossRefGoogle Scholar
  88.  88.
    Toulis KA, Anastasilakis A, Tzellos TG et al (2010) Thyroid 20:1163PubMedCrossRefGoogle Scholar
  89.  89.
    Zeng H, Briske-Anderson M, Idso JP et al (2006) J Nutr 136:1528PubMedGoogle Scholar
  90.  90.
    Krassas GE, Poppe K, Glinoer D (2010) Endocr Rev 31:702PubMedCrossRefGoogle Scholar
  91.  91.
    Abbassi-Ghanavati M, Casey BM, Spong CY et al (2010) Obstet Gynecol 116:381PubMedCrossRefGoogle Scholar
  92.  92.
    Smyth PP, Wijeyaratne CN, Kaluarachi WN et al (2005) Thyroid 15:474PubMedCrossRefGoogle Scholar
  93.  93.
    Pearce EN, Farwell AP, Braverman LE (2003) N Engl J Med 348:2646PubMedCrossRefGoogle Scholar
  94.  94.
    Prummel MF, Wiersinga WM (2004) Eur J Endocrinol 150:751PubMedCrossRefGoogle Scholar
  95.  95.
    Männistö T, Vääräsmäki M, Pouta A et al (2009) J Clin Endocrinol Metab 94:772PubMedCrossRefGoogle Scholar
  96.  96.
    Haddow JE, Cleary-Goldman J, McClain MR et al (2010) Obstet Gynecol 116:58PubMedCrossRefGoogle Scholar
  97.  97.
    Schomburg L, Köhrle J (2008) Mol Nutr Food Res 52:1235PubMedCrossRefGoogle Scholar
  98.  98.
    Negro R, Greco G, Mangieri T et al (2007) J Clin Endocrinol Metab 92:1263PubMedCrossRefGoogle Scholar
  99.  99.
    Zimmermann MB (2009) Endocr Rev 30:376PubMedCrossRefGoogle Scholar
  100. 100.
    Bailey RL, Gahche JJ, Lentino CV et al (2011) J Nutr 141:261PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.University of SurreyGuildfordUK

Personalised recommendations