Skip to main content

Synthetic Fillers

  • Chapter
  • First Online:

Abstract

Soft tissue augmentation has a history spanning over a century, but the field has seen a renaissance over the past two decades, with an explosion of available agents and an evolution of techniques. With advances in medicine and changes in lifestyle, people are leading longer, more active lives. With a healthier aging population, there has been a desire to maintain or recreate a youthful appearance.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   149.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. American Society of Plastic Surgeons Survey Data. http://www.plasticsurgery.org. Accessed 31 July 2010.

  2. Rohrich RJ, Pessa JE. The retaining system of the face: histologic evaluation of the septal boundaries of the subcutaneous fat compartments. Plast Reconstr Surg. 2008;121(5):1804–9.

    Article  PubMed  CAS  Google Scholar 

  3. Schaverien MV, Pessa JE, Rohrich RJ. Vascularized membranes determine the anatomical boundaries of the subcutaneous fat compartments. Plast Reconstr Surg. 2009;123(2):695–700.

    Article  PubMed  CAS  Google Scholar 

  4. Le Louarn CL, Buthiau D, Buis J. Structural aging: the facial recurve concept. Aesthetic Plast Surg. 2007;31:213–8.

    Article  PubMed  Google Scholar 

  5. Pessa JE. An algorithm of facial aging: verification of Lambros’s theory by three-dimensional stereolithography, with reference to the pathogenesis of midfacial aging, scleral show, and the lateral suborbital trough deformity. Plast Reconstr Surg. 2000;106:479–88.

    Article  PubMed  CAS  Google Scholar 

  6. Wang F, Garza LA, Kang S, et al. In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Arch Dermatol. 2007;143:155–63.

    Article  PubMed  CAS  Google Scholar 

  7. Gravier MH, Bass LS, Busso M, Jasin ME, Narins RS, Tzikas TL. Calcium hydroxylapatite (Radiesse) for correction of the mid- and lower face: concensus recommendations. Plast Reconstr Surg. 2007;120(6 Suppl):55S–66S.

    Article  Google Scholar 

  8. Coleman KM, Voigts R, Devore DP, Termin P, Coleman III WP. Neocollagenesis after Injection of Calcium Hydroxylapatite Composition in a Canine Model. Dermatol Surg. 2008;34:S53–5.

    Article  PubMed  CAS  Google Scholar 

  9. Marmur ES, Phelps R, Goldberg DJ. Clinical, histologic, and electron microscopic findings after injection of a calcium hydroxylapatite filler. J Cosmet Laser Ther. 2004;6(4):223–6.

    Article  PubMed  Google Scholar 

  10. Lizzul PF, Narurkar VA. The role of calcium hydroxylapatite (Radiesse) in nonsurgical aesthetic rejuvenation. J Drugs Dermatol. 2010;9(5):446–50.

    PubMed  Google Scholar 

  11. Busso M, Voigts R. An investigation of changes in physical properties of injectable calcium hydroxylapatite in a carrier gel when mixed with lidocaine and with lidocaine/epinephrine. Dermatol Surg. 2008;34:S16–24.

    Article  PubMed  CAS  Google Scholar 

  12. Berlin AL, Hussain M, Goldberg DJ. Calcium hydroxylapatite filler for facial rejuvenation: a histologic and immunohistochemical analysis. Dermatol Surg. 2008;34:S64–7.

    Article  PubMed  CAS  Google Scholar 

  13. Monheit GD, Coleman KM. Hyaluronic acid fillers. Dermatol Ther. 2006;19:141–50.

    Article  PubMed  Google Scholar 

  14. Tezel A, Fredrickson GH. The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther. 2008;10:3–42.

    Article  Google Scholar 

  15. Kinney BM. Injecting Puragen Plus into the nasolabial folds: preliminary observation of FDA trial. Aesthetic Surg J. 2006;26(6):741–8.

    Article  CAS  Google Scholar 

  16. FDA Approval Order for Sculptra Aesthetic (P030050/S2). 28 July 2009.

    Google Scholar 

  17. Narins RS. Minimizing adverse events associated with poly-l-lactic acid injection. Dermatol Surg. 2008;34:S100–4.

    Article  PubMed  CAS  Google Scholar 

  18. Cohen JL. Understanding, avoiding, and managing dermal filler complications. Dermatol Surg. 2008;34 Suppl 1:S92–9.

    Article  PubMed  CAS  Google Scholar 

  19. Rossner F, Rossner M, Harmann V, Erdmann R, Wiest LG, Rzany B. Decrease of reported adverse events to injectable polylactic acid after recommending an increased dilution: 8-year results from the Injectable Filler Safety study. J Cosmet Dermatol. 2009;8(1):14–8.

    Article  PubMed  Google Scholar 

  20. Rotunda AM, Narins RS. Poly-l-lactic acid: a new dimension in soft tissue augmentation. Dermatol Ther. 2006;19(3):151–8.

    Article  PubMed  Google Scholar 

  21. Cohen SR, Berner CR, Busso M, et al. ArteFill: a long-lasting injectable wrinkle filler material – summary of the U.S. Food and Drug Administration trials and a progress report on 4- to 5-year outcomes. Plast Reconstr Surg. 2006;118(Suppl):64S.

    Article  PubMed  CAS  Google Scholar 

  22. Smith KC. New fillers for the new man. Dermatol Ther. 2007;20(6):388–93.

    Article  PubMed  Google Scholar 

  23. Brown JB, Fryer MP, Randall P, Lu M. Silicones in plastic surgery; laboratory and clinical investigations, a preliminary report. Plast Reconstr Surg. 1953;12:374–6.

    Article  CAS  Google Scholar 

  24. Balkin SW. DPM injectable silicone and the foot: a 41-year clinical and histologic history. Dermatol Surg. 2005;31:1557.

    Article  Google Scholar 

  25. Narins RS, Beer K. Liquid injectable silicone: a review of its history, immunology, technical considerations, complications, and potential. Plast Reconstr Surg. 2006;118(Suppl):77S–84S.

    Article  PubMed  CAS  Google Scholar 

  26. Orentreich DS, Jones DH. Liquid injectable silicone. In: Carruthers J, Carruthers A, editors. Soft tissue augmentation. Philadelphia, PA: Elsevier Saunders; 2005. p. 77–91.

    Google Scholar 

  27. Lupo MP, Swetman G, Waller W. The effect of lidocaine when mixed with large gel particle hyaluronic acid filler on tolerability and longevity: a six-month trial. J Drugs Dermatol. 2010;9(9):1097–100.

    PubMed  Google Scholar 

  28. Lambros VS. Discussion: quantitative evaluation of volume augmentation in the tear trough with a hyaluronic-based filler: a three-dimensional analysis. Plast Reconstr Surg. 2010;125:1523–4.

    Article  PubMed  CAS  Google Scholar 

  29. Lambros VS. Hyaluronic acid injections for correction of the tear trough deformity. Plast Reconstr Surg. 2007;120(6S):74S–80S.

    Article  PubMed  Google Scholar 

  30. Lambros V. Observations on periorbital and midface aging. Plast Reconstr Surg. 2007;120(5):1367–76.

    Article  PubMed  CAS  Google Scholar 

  31. Goldberg RA, McCann JD, Fiaschetti D, Ben Simon GJ. What causes eyelid bags? Analysis of 114 consecutive patients. Plast Reconstr Surg. 2005;115:1395–402.

    Article  PubMed  CAS  Google Scholar 

  32. Matros E, Garcia JA, Yaremchuk MJ. Changes in eyebrow position and shape with aging. Plast Reconstr Surg. 2009;124(4):1296–301.

    Article  PubMed  CAS  Google Scholar 

  33. Rohrich RJ, Pessa JE, Ristow B. The youthful cheek and the deep medial fat compartment. Plast Reconstr Surg. 2008;121(6):2107–12.

    Article  PubMed  CAS  Google Scholar 

  34. Rohrich RJ, Pessa JE. The fat compartments of the face: anatomy and clinical implications for cosmetic surgery. Plast Reconstr Surg. 2007;119(7):2219–27.

    Article  PubMed  CAS  Google Scholar 

  35. Sykes JM. Applied anatomy of the temporal region and forehead for injectable fillers. J Drugs Dermatol. 2009;8(10S):s24–7.

    PubMed  Google Scholar 

  36. Shaw Jr RB, Kahn DM. Aging of the midface bony elements: a three-dimensional computed tomographic study. Plast Reconstr Surg. 2007;119:675–81.

    Article  PubMed  CAS  Google Scholar 

  37. Humphrey CD, Arkins JP, Dayan SH. Soft tissue fillers in the nose. Aesthet Surg J. 2009;29:477–84.

    Article  PubMed  Google Scholar 

  38. deLacerda DA, Zancanaro P. Filler rhinoplasty. Dermatol Surg. 2007;33:S207–12.

    Article  CAS  Google Scholar 

  39. Becker H. Nasal augmentation with calcium hydroxylapatite in a carrier-based gel. Plast Reconstr Surg. 2008;121(6):2142–7.

    Article  PubMed  CAS  Google Scholar 

  40. Mandy S. Art of the Lip. Dermatol Surg. 2007;33:521–2.

    Article  PubMed  CAS  Google Scholar 

  41. Pessa JE, Slice DE, Hanz KR, Broadbent Jr TH, Rohrich RJ. Aging and the shape of the mandible. Plast Reconstr Surg. 2008;121(1):196–200.

    Article  PubMed  CAS  Google Scholar 

  42. Reece EM, Pessa JE, Rohrich RJ. The mandibular septum: anatomical observations of the jowls in aging – implications for facial rejuvenation. Plast Reconstr Surg. 2008;121(4):1414–20.

    Article  PubMed  CAS  Google Scholar 

  43. Rohrich RJ, Pessa JE. The anatomy and clinical implications of perioral submuscular fat. Plast Recontr Surg. 2009;124(1):266–71.

    Article  CAS  Google Scholar 

  44. Vleggar D, Fitzgerald R. Dermatological implications of skeletal aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol. 2008;7(3):209. 12.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Brad T. Kovach .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Kovach, B.T., Sengelmann, R.S. (2012). Synthetic Fillers. In: Hartstein, M., Wulc, A., Holck, D. (eds) Midfacial Rejuvenation. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1007-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-1007-2_12

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-1006-5

  • Online ISBN: 978-1-4614-1007-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics