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Ordered Mesoporous Silica for the Delivery of Poorly Soluble Drugs

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Controlled Release in Oral Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Ordered mesoporous silica (OMS) materials offer much promise as carriers for poorly soluble drugs because of their high porosity, large specific surface area, and uniform pore shape and dimensions. Liquid as well as solid type phases of drugs, confined and stabilized in the pores of OMS, can exhibit special physicochemical properties and enhanced dissolution rates compared to crystalline forms. The ability to design mesopore size precisely provides the formulation scientist with the potential to readily attain and closely control drug release. Absorption enhancement may require stable supersaturation of released drug. If this can be effected (viz. drug precipitation attenuated by suitable formulation adjuvants), systemic absorption can be enhanced. In vivo proof of concept of OMS as a dissolution-enhancing technology has been demonstrated in various animal species. The findings are promising and suggest that adsorption on OMS can successfully enhance and control absorption of poorly soluble drugs.

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Acknowledgments

The authors acknowledge the Flemish Government for financial support from the Industrial Research Fund (IOF). MVS acknowledges the Flemish Institute for the Promotion of Innovation through Science and Technology (IWT-Vlaanderen) for a PhD grant. RM acknowledges the Research Fund-Flanders (FWO- Vlaanderen) for a postdoctoral research fellowship. JAM acknowledges the Flemish Government for long-term structural funding (Methusalem).

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Authors and Affiliations

  1. Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, Leuven, Belgium

    Michiel Van Speybroeck, Pieter Annaert, Guy Van den Mooter & Patrick Augustijns

  2. Center for Surface Chemistry and Catalysis, Katholieke Universiteit Leuven, Leuven, Belgium

    Randy Mellaerts & Johan Adriaan Martens

Authors
  1. Michiel Van Speybroeck
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  2. Randy Mellaerts
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  3. Johan Adriaan Martens
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  4. Pieter Annaert
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  5. Guy Van den Mooter
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  6. Patrick Augustijns
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Corresponding author

Correspondence to Patrick Augustijns .

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Editors and Affiliations

  1. The John Arbuthnott Building, Strathclyde Institute of Pharmacy and Bi, Taylor Street 27, Glasgow, G4 0NR, United Kingdom

    Clive G. Wilson

  2. Berwyn Baptist Road 571, Devon, 19333, Pennsylvania, USA

    Patrick J. Crowley

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Van Speybroeck, M., Mellaerts, R., Martens, J.A., Annaert, P., Van den Mooter, G., Augustijns, P. (2011). Ordered Mesoporous Silica for the Delivery of Poorly Soluble Drugs. In: Wilson, C., Crowley, P. (eds) Controlled Release in Oral Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-1004-1_10

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