Advertisement

Ocular Cicatricial Pemphigoid

Chapter

Abstract

Cicatricial pemphigoid (mucous membrane pemphigoid) is a chronic autoimmune disease of unknown etiology that mainly affects mucous membranes showing conjunctival involvement in about 70% of cases. Skin lesions occur in 10–24% of patients [1]. It is a bilateral sight-threatening disease characterized by progressive conjunctival cicatrization associated with secondary corneal neovascularization and scarring. The disease usually presents between the ages of 30 and 90 years [2].

Keywords

Bullous Pemphigoid Hemorrhagic Cystitis Benzalkonium Chloride Basement Membrane Zone Keratoconjunctivitis Sicca 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Michel B, Thomas CI, Levine MR, et al. Cicatricial pemphigoid and its relationship to ocular pemphigus and essential shrinkage of the conjunctiva. Ann Ophthalmol. 1975;7(1):11–20.PubMedGoogle Scholar
  2. 2.
    Rauz S, Maddison PG, Dart JKG. Evaluation of mucous membrane pemphigoid with ocular involvement in young patients. Ophthalmology. 2005;112:1268–74.PubMedCrossRefGoogle Scholar
  3. 3.
    Buhac J, et al. Coexistence of pemphigus vulgaris and ocular cicitricial pemphigoid. J Am Acad Dermatol. 1996;34:884.PubMedCrossRefGoogle Scholar
  4. 4.
    Frith PA, Venning VA, et al. Conjunctival involvement in cicatricial and bullous pemphigoid: a clinical and immunopathologic study. Br J Ophthalmol. 1989;73:52–6.PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Neumann R, Tauber J, Foster Cs. Remission and recurrence after withdrawal of therapy for ocular cicatricial pemphigoid. Ophthalmology. 1991;98:858–62.PubMedCrossRefGoogle Scholar
  6. 6.
    Hardy KM, et al. Benign mucous membrane pemphigoid. Arch Dermatol. 1971;104:467.PubMedCrossRefGoogle Scholar
  7. 7.
    Power WJ, et al. Increasing the diagnostic yield of conjunctival biopsy in patients with suspected ocular cicatricial pemphigoid. Ophthalmology. 1995;102:1158.PubMedCrossRefGoogle Scholar
  8. 8.
    Bhol K, et al. Differences in the anti-basement membrane zone antibodies in ocular and psuedo-ocular cicatricial pemphigoid. Curr Eye Res. 1996;15:521.PubMedCrossRefGoogle Scholar
  9. 9.
    Haider N, Neumann R, Foster CS, Ahmed AR. Report on the sequence of DQB1 *0301 gene in ocular cicatricial pemphigoid patients. Curr Eye Res. 1992;11:1233.PubMedCrossRefGoogle Scholar
  10. 10.
    Foster CS, Wilson LA, Ekins MB. Immunosuppressive therapy for progressive ocular cicatricial pemphigoid. Ophthalmology. 1989;89:340.CrossRefGoogle Scholar
  11. 11.
    Fiore PM, Jacobs IH, Goldberg DE. Drug-induced pemphigoid. Arch Ophthalmol. 1987;105:1660.PubMedCrossRefGoogle Scholar
  12. 12.
    Petr I. Drops show long term effects. www.Ophthalmologytimes.Com. Accessed 15 Jan 2010.
  13. 13.
    Rosenthal P, Cotter JM. Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. Am J Ophthalmol. 1996;122(1):38–52.Google Scholar
  14. 14.
    Donnenfeld ED, Perry HD, Wallerstein A, et al. Subconjunctival mitomycin C for the treatment of ocular cicatricial pemphigoid. Ophthalmology. 1999;106:72–9.PubMedCrossRefGoogle Scholar
  15. 15.
    Secchi Ag, Tognon MS. Intraoperative mitomycin C in the treatment of cicatricial obliterations of conjunctival fornices. Am J Ophthalmol. 1996;122(5):728–30.PubMedGoogle Scholar
  16. 16.
    Heiligenhans A, Shore JW, Rubin PA, Foster CS. Long-term results of mucous membrane grafting in ocular cicatricial pemphigoid. Ophthalmology. 1993;100:1283.CrossRefGoogle Scholar
  17. 17.
    Sybille Thoma-Uszynski, Wolfgang Uter, Susanne Schwietzke, Silke C Hofmann, Thomas Hunziker, Philippe Bernard, Regina Treudler, Christos C Zouboulis, Gerold Schuler, Luca Borradori and Michael Hertl BP230- and BP180-specific Auto-Antibodies in Bullous Pemphigoid Journal of Investigative Dermatology (2004) 122, 1413–1422; doi:10.1111/j.0022-20X.2004.22603.xGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of OphthalmologyUniversity Hospitals of Cleveland, Cleveland Clinic FoundationClevelandUSA

Personalised recommendations