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Spectroscopy and Electrochemistry of Peptide-Based Self-Assembled Monolayers

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Sensors and Microsystems

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 109))

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Abstract

Mono and bi-component peptide-based self-assembled monolayers (SAMs) immobilized on a gold surface were studied by electrochemical and spectroscopic techniques. The peptides investigated were exclusively formed by Cα-tetrasubstituted amino acids. These residues, due to their peculiar conformational properties, constrain the peptide in a helical conformation, as confirmed by X-ray diffraction structure determinations, and Circular Dichroism and NMR experiments in solution. Both mono-and bi-component peptide SAMs were functionalized with electroactive, fluorescent chromophores strongly absorbing in the UV region. While electrochemical experiments indicated the formation of densely-packed films on the gold surface, fluorescence spectroscopy revealed the occurrence of aromatic-aromatic interactions between the pyrene units functionalizing the peptide chains, obtaining important information on the structural and dynamical properties of the peptide SAMs investigated.

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References

  1. Niemeyer CM, Mirkin CA (eds) (2004) Nanobiotechnology. Wiley-VCH, Weinheim

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  2. Bianco A, Venanzi M, Aleman C (2011) Peptide-based materials: from nanostructures to applications. J Pept Sci 17:73–74

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  3. Gatto E, Caruso M, Porchetta A, Toniolo C, Formaggio F, Crisma M, Venanzi M (2011) Photocurrent generation through peptide-based self-assembled monolayers on a gold surface: antenna and junction effects. J Pept Sci 17:124–131

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Acknowledgments

The financial support (PRIN 2008, Project 20088NTBKR) of the Italian Ministry for University and Research (MIUR) is acknowledged.

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Authors and Affiliations

  1. Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, Italy

    M. Caruso, A. Porchetta, E. Gatto & M. Venanzi

  2. ICB, Padova Unit, CNR, Department of Chemistry, University of Padova, Padova, Italy

    M. Crisma, F. Formaggio & C. Toniolo

Authors
  1. M. Caruso
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  2. A. Porchetta
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  3. E. Gatto
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  4. M. Venanzi
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  5. M. Crisma
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  6. F. Formaggio
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  7. C. Toniolo
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Corresponding author

Correspondence to M. Venanzi .

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Editors and Affiliations

  1. University of Rome Tor Vergata, Rome, Italy

    Arnaldo D’Amico

  2. University of Rome Tor Vergata, Rome, Italy

    Corrado Di Natale

  3. Technologies, Energy and the Environment, ENEA, Italian National Agency for New, Rome, Italy

    Lucia Mosiello

  4. Technologies, Energy and the Environment, ENEA, Italian National Agency for New, Rome, Italy

    Giovanna Zappa

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© 2012 Springer Science+Business Media, LLC

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Caruso, M. et al. (2012). Spectroscopy and Electrochemistry of Peptide-Based Self-Assembled Monolayers. In: D’Amico, A., Di Natale, C., Mosiello, L., Zappa, G. (eds) Sensors and Microsystems. Lecture Notes in Electrical Engineering, vol 109. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0935-9_13

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  • DOI: https://doi.org/10.1007/978-1-4614-0935-9_13

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4614-0934-2

  • Online ISBN: 978-1-4614-0935-9

  • eBook Packages: EngineeringEngineering (R0)

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