Abstract
Many optical biosensors detect molecules that either are attached to a surface, or are in close proximity to one. Therefore, understanding the optical properties of surfaces, and how these properties affect molecular interferometry, is a central topic of this book. Surfaces are planes of dielectric discontinuity that split the amplitude of waves into transmitted and reflected partial waves (Fig. 4.1). Surfaces impose electromagnetic boundary conditions that produce constructive or destructive interference of the incident and reflected waves. On the wrong type of surface (unity reflection with a π phase shift, as for a metal surface), a thin protein film can be entirely invisible to an incident plane wave (but not a surface wave), because the electric field strength at the molecular layer is canceled by destructive interference between the incident and reflected waves. In this situation, a light wave can pass right through the layer without ever polarizing it, and hence never sensing any change in the optical path length. This is perhaps the oldest and simplest form of optical cloaking [1].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Selected Bibliography
Selected Bibliography
Heavens, O.S.: Optical Properties of Thin Solid Films. Dover, New York (1991) (An old classic on thin films)
Maier, S.A.: Plasmonics: Fundamentals and Applications. Springer, New York (2007) (A good modern review of plasmonics)
References
Ergin, T., Stenger, N., Brenner, P., Pendry, J.B., Wegener, M.: Three-dimensional invisibility cloak at optical wavelengths. Science 328, 337–339 (2010)
Wang, X., Zhao, M., Nolte, D.D.: Common-path interferometric detection of protein on the BioCD. Appl. Opt. 46, 7836–7849 (2007)
Jenison, R., La, H., Haeberli, A., Ostroff, R., Polisky, B.: Silicon-based biosensors for rapid detection of protein or nucleic acid targets. Clin. Chem. 47, 1894–1900 (2001)
Zhao, M., Wang, X., Nolte, D.D.: Molecular interferometric imaging. Opt. Express 16, 7102–7118 (2008)
Ozkumur, E., Yalcin, A., Cretich, M., Lopez, C.A., Bergstein, D.A., Goldberg, B.B., Chiari, M., Unlu, M.S.: Quantification of DNA and protein adsorption by optical phase shift. Biosens. Bioelectron. 25, 167–172 (2009)
de la Pena, J.L., Gonzalez, F., Saiz, J.M., Moreno, F., Valle, P.J.: Application of a double-interaction model to the backscattering from particulate surfaces. Opt. Eng. 38, 1017–1023 (1999)
Nebeker, B.M., de la Pena, J.L., Hirleman, E.D.: Comparisons of the discrete-dipole approximation and modified double interaction model methods to predict light scattering from small features on surfaces. J. Quant. Spectrosc. Radiat. Transf. 70, 749–759 (2001)
Homola, J.: Surface Plasmon Resonance Based Sensors. Springer, Berlin (2006)
Schasfoort, R.B.M.: Handbook of Surface Plasmon Resonance. Royal Society of Chemistry, Cambridge (2008)
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Nolte, D.D. (2012). Surface Optics. In: Optical Interferometry for Biology and Medicine. Bioanalysis, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0890-1_4
Download citation
DOI: https://doi.org/10.1007/978-1-4614-0890-1_4
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-0889-5
Online ISBN: 978-1-4614-0890-1
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)