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Tissue Engineering in Drug Delivery

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Fundamentals and Applications of Controlled Release Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

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Abstract

Over the last 20 years, the fields of tissue engineering and regenerative medicine have emerged with the goals of restoring, maintaining, or improving tissue function. This is currently addressed with the creation of biologically active biomaterials or scaffolds seeded with either progenitor or differentiated cells that substitute for tissue or organs. Paracrine factors or other drugs are incorporated into these scaffolds to promote tissue regeneration and function. Precise control of both timing and presentation of these drugs is necessary for sufficient efficacy. This chapter provides an overview of the common biomaterials and drugs encountered in bone, cartilage, neural, and cardiovascular tissue engineering, as well as current strategies and future directions for drug delivery in tissue engineering.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of Texas at Austin, 1 University Station, C0800, Austin, TX, 78712, USA

    Charles T. Drinnan & Laura J. Suggs

  2. Department of Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA

    Laura R. Geuss

  3. Department of Biomedical Engineering, University of Akron, Akron, OH, USA

    Ge Zhang

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  1. Charles T. Drinnan
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  2. Laura R. Geuss
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  3. Ge Zhang
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  4. Laura J. Suggs
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Correspondence to Laura J. Suggs .

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  1. Rue Maurice Schumann 3, Phalempin, 59133, France

    Juergen Siepmann

  2. , Department of Pharmaceutics, University of Minnesota, Harvard Street SE 308, Minneapolis, 55455, Minnesota, USA

    Ronald A. Siegel

  3. , School of Pharmacy, Griffith University, Parklands Drive 1, Southport, 4215, Queensland, Australia

    Michael J. Rathbone

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Drinnan, C.T., Geuss, L.R., Zhang, G., Suggs, L.J. (2012). Tissue Engineering in Drug Delivery. In: Siepmann, J., Siegel, R., Rathbone, M. (eds) Fundamentals and Applications of Controlled Release Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0881-9_17

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