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Thyroid Cancer pp 109-131 | Cite as

Staging Systems for Differentiated Thyroid Carcinomas

  • Ronnie Meiyi Wong
  • Glenn D. Braunstein
Chapter
Part of the Endocrine Updates book series (ENDO, volume 32)

Abstract

A multitude of retrospective studies have identified prognostic factors for the mortality and recurrence rates of thyroid carcinoma. Using a combination of these factors, many medical institutions have developed their own systems for the staging of thyroid carcinoma and the system used depends on physician or medical center preference. The stage of cancer generally refers to the extent, or invasion of disease, and how far the cancer has metastasized. The goal of each staging system is to provide a more precise depiction of the tumor, to aid the physician in the selection of the best course of treatment for the patient, and to assist in the prediction of disease-specific mortality. Depending on which system is utilized, major prognostic factors can include histologic variant, tumor grade, patient age, tumor size, lymph node involvement, invasion of adjacent structures surrounding the neck, or distant metastasis to other organs.

Most staging systems described in this chapter incorporate these prognostic factors while some may also include gender or extent of thyroidectomy performed as contributing features. Some systems restrict their staging and applicability to the relatively low risk and long-term survivability of the well-differentiated papillary (PTC) and follicular thyroid carcinomas (FTC). Other staging systems include the higher risk, less differentiated thyroid carcinomas, namely medullary (MTC) and the more fatal anaplastic thyroid carcinomas (ATCs).

Keywords

Prognostic factors Histologic variant Tumor grade Lymph node involvement Papillary thyroid carcinoma Follicular thyroid carcinoma Anaplastic thyroid carcinoma 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Divison of Endocrinology, Diabetes, and Metabolism, Department of MedicineCedars-Sinai Medical CenterLos AngelesUSA

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