Skip to main content

Surgical Management of Thyroid Cancer

  • Chapter
  • First Online:
Thyroid Cancer

Part of the book series: Endocrine Updates ((ENDO,volume 32))

  • 1816 Accesses

Abstract

Surgery on the thyroid gland was first performed around 500 a.d. Later, Abū al-Qāsim, a surgeon innovator also known as Albucasis, wrote a 30-volume treatise on numerous instruments he developed as well as procedures he performed. Prior to his death in 1013 a.d., he performed the first thyroid surgery that was successful. Prior to 1850, thyroid surgery was plagued with morbidity and mortality related to hemorrhage, lack of anesthesia, and infection. Two key discoveries brought surgical technique closer to avoiding this complication. Sandstrom first described the human parathyroid glands in 1880 (Rogers-Stevane and Kauffman, Otolaryngol Clin North Am 41:1059, 2008). His discovery led to the anatomical understanding of parathyroid gland blood supply in 1907 by Halstead and Evans. With the further understanding of the parathyroids’ role in calcium physiology, these discoveries led to the development of surgical techniques that spared the glands in order to maintain calcium homeostasis. Contemporary advancements continue to build on these discoveries. The advent of electrocautery followed by the ultrasonic shears encourages hemostasis and decreases operating time. Minimally invasive techniques have decreased the trauma and improved the cosmesis of the procedure. Finally, intraoperative nerve monitoring provides an additional defense against dreaded RLN injury which impact airway integrity as well as phonation. Postoperative parathyroid hormone levels help predict likelihood of postoperative hypocalcemia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. DuBose J, Barnett R, Ragsdale T. Honest and sensible surgeons: the history of thyroid surgery. Curr Surg. 2004;61:213–9.

    PubMed  Google Scholar 

  2. Hegner CF. A history of thyroid surgery. Ann Surg. 1932;95:481–92.

    CAS  PubMed  Google Scholar 

  3. Rogers-Stevane J, Kauffman GL. A historical perspective on surgery of the thyroid and parathyroid glands. Otolaryngol Clin North Am. 2008;41:1059.

    PubMed  Google Scholar 

  4. Summers G. Thyroid and parathyroid surgery. In: Krespi Y, Ossoff R, editors. Complications in head and neck surgery. Philadelphia: W.B. Saunders; 1993.

    Google Scholar 

  5. Werner JA, Davis RK. Metastases in head and neck cancer. Berlin: Springer; 2004. 233.

    Google Scholar 

  6. Heimgartner S, Zbaeren P. Thyroid carcinoma presenting as a metastasis to the parapharyngeal space. Otolaryngol Head Neck Surg. 2009;140:435–6.

    PubMed  Google Scholar 

  7. Sundram F. Clinical use of PET/CT in thyroid cancer diagnosis and management. Biomed Imag Interv J. 2006;2:1–5.

    Google Scholar 

  8. Shaha AR, Shah JP, Loree TR. Risk group stratification and prognostic factors in papillary carcinoma of thyroid. Ann Surg Oncol. 1996;3:534–8.

    CAS  PubMed  Google Scholar 

  9. Podnos YD, Smith D, Wagman LD, Ellenhorn JD. The implication of lymph node metastasis on survival in patients with well-differentiated thyroid cancer. Am Surg. 2005;71:731–4.

    PubMed  Google Scholar 

  10. Shaha AR, Shah JP, Loree TR. Low-risk differentiated thyroid cancer: the need for selective treatment. Ann Surg Oncol. 1997;4:328–33.

    CAS  PubMed  Google Scholar 

  11. Hay ID, McConahey WM, Goellner JR. Managing patients with papillary thyroid carcinoma: insights gained from the Mayo Clinic’s experience of treating 2,512 consecutive patients during 1940 through 2000. Trans Am Clin Climatol Assoc. 2002;113:241–60.

    PubMed Central  PubMed  Google Scholar 

  12. Bilimoria KY, Bentrem DJ, Linn JG, et al. Utilization of total thyroidectomy for papillary thyroid cancer in the United States. Surgery. 2007;142:906–13. discussion 913.e901-902.

    PubMed  Google Scholar 

  13. Suliburk J, Delbridge L. Surgical management of well-differentiated thyroid cancer: state of the art. Surg Clin North Am. 2009;89:1171.

    PubMed  Google Scholar 

  14. Cooper DS, Doherty GM, Haugen BR, et al. Revised American Thyroid Association Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167–214.

    PubMed  Google Scholar 

  15. Haymart MR, Cayo M, Chen H. Papillary thyroid microcarcinomas: big decisions for a small tumor. Ann Surg Oncol. 2009;16:3132–9.

    PubMed  Google Scholar 

  16. Sugitani I, Toda K, Yamada K, Yamamoto N, Ikenaga M, Fujimoto Y. Three distinctly different kinds of papillary thyroid microcarcinoma should be recognized: our treatment strategies and outcomes. World J Surg. 2010;12:12.

    Google Scholar 

  17. Kloos RT, Amer Thyroid A. Medullary thyroid cancer: management guidelines of the American Thyroid Association (vol 19, pg 565, 2009). Thyroid. 2009;19:1295–5.

    Google Scholar 

  18. Terris DJ, Seybt MW, Gourin CG, Chin E. Ultrasonic technology facilitates minimal access thyroid surgery. Laryngoscope. 2006;116:851–4.

    PubMed  Google Scholar 

  19. Koutsoumanis K, Koutras AS, Drimousis PG, et al. The use of a harmonic scalpel in thyroid surgery: report of a 3-year experience. Am J Surg. 2007;193:693–6.

    PubMed  Google Scholar 

  20. Shimizu K, Akira S, Jasmi AY, et al. Video-assisted neck surgery: endoscopic resection of thyroid tumors with a very minimal neck wound. J Am Coll Surg. 1999;188:697–703.

    CAS  PubMed  Google Scholar 

  21. Miccoli P, Berti P, Conte M, Bendinelli C, Marcocci C. Minimally invasive surgery for thyroid small nodules: preliminary report. J Endocrinol Invest. 1999;22:849–51.

    CAS  PubMed  Google Scholar 

  22. Del Rio P, Sommaruga L, Cataldo S, Robuschi G, Arcuri MF, Sianesi M. Minimally invasive video-assisted thyroidectomy: the learning curve. Eur Surg Resarch. 2008;41:33–6.

    Google Scholar 

  23. Miccoli P, Berti P, Frustaci GL, Ambrosini CE, Materazzi G. Video-assisted thyroidectomy: indications and results. Langenbecks Arch Surg. 2006;391:68–71.

    PubMed  Google Scholar 

  24. Lombardi CP, Raffaelli M, Princi P, et al. Safety of video-assisted thyroidectomy versus conventional surgery. Head Neck. 2005;27:58–64.

    PubMed  Google Scholar 

  25. Tabaqchali MA, Hanson JM, Proud G. Drains for thyroidectomy/parathyroidectomy: fact or fiction? Ann R Coll Surg Engl. 1999;81:302–5.

    CAS  PubMed Central  PubMed  Google Scholar 

  26. Terris DJ, Anderson SK, Watts TL, Chin E. Laryngeal nerve monitoring and minimally invasive thyroid surgery. Arch Otolaryngol Head Neck Surg. 2007;133:1254–7.

    PubMed  Google Scholar 

  27. Miccoli P, Elisei R, Materazzi G, et al. Minimally invasive video-assisted thyroidectomy for papillary carcinoma: a prospective study of its completeness. Surgery. 2002;132:1070–3. discussion 1073–1074.

    PubMed  Google Scholar 

  28. Terris DJ, Angelos P, Steward DL, Simental AA. Minimally invasive video-assisted thyroidectomy – a multi-institutional North American experience. Arch Otolaryngol Head Neck Surg. 2008;134:81–4.

    PubMed  Google Scholar 

  29. Lewis CM, Chung WY, Holsinger FC. Feasibility and surgical approach of transaxillary robotic thyroidectomy without CO2 insufflation. Head Neck. 2010;32:121–6.

    PubMed  Google Scholar 

  30. Kang SW, Lee SC, Lee SH, et al. Robotic thyroid surgery using a gasless, transaxillary approach and the da Vinci S system: the operative outcomes of 338 consecutive patients. Surgery. 2009;146:1048–55.

    PubMed  Google Scholar 

  31. Lahey FH, Hoover WB. Injuries to the recurrent laryngeal nerve in thyroid operations: their management and avoidance. Ann Surg. 1938;108:545–62.

    CAS  PubMed  Google Scholar 

  32. Thomusch O, Machens A, Sekulla C, et al. Multivariate analysis of risk factors for postoperative complications in benign goiter surgery: prospective multicenter study in Germany. World J Surg. 2000;24:1335–41.

    CAS  PubMed  Google Scholar 

  33. Myssiorek D. Recurrent laryngeal nerve paralysis: anatomy and etiology. Otolaryngol Clin North Am. 2004;37:25–44.

    PubMed  Google Scholar 

  34. Dralle H, Sekulla C, Haerting J, et al. Risk factors of paralysis and functional outcome after recurrent laryngeal nerve monitoring in thyroid surgery. Surgery. 2004;136:1310–22.

    PubMed  Google Scholar 

  35. Donnellan KA, Pitman KT, Cannon CR, Replogle WH, Simmons JD. Intraoperative laryngeal nerve monitoring during thyroidectomy. Arch Otolaryngol Head Neck Surg. 2009;135:1196–8.

    PubMed  Google Scholar 

  36. Zarnegar R, Brunaud L, Clark OH. Prevention, evaluation, and management of complications following thyroidectomy for thyroid carcinoma. Endocrinol Metab Clin North Am. 2003;32:483–502.

    PubMed  Google Scholar 

  37. Gourin CG, Johnson JT. Postoperative complications. In: RG W, editor. Surgery of thyroid and parathyroid glands. Philadelphia: Saunders (Elsevier Science); 2003. p. 433–43.

    Google Scholar 

  38. Wingert DJ, Friesen SR, Iliopoulos JI, Pierce GE, Thomas JH, Hermreck AS. Post-thyroidectomy hypocalcemia. Incidence and risk factors. Am J Surg. 1986;152:606–10.

    CAS  PubMed  Google Scholar 

  39. Rimpl I, Wahl RA. Surgery of nodular goiter: postoperative hypocalcemia in relation to extent of resection and manipulation of the parathyroid glands. Langenbecks Arch Chir Suppl Kongressbd. 1998;115:1063–6.

    CAS  PubMed  Google Scholar 

  40. Sosa JA, Bowman HM, Tielsch JM, Powe NR, Gordon TA, Udelsman R. The importance of surgeon experience for clinical and economic outcomes from thyroidectomy. Ann Surg. 1998;228:320–30.

    CAS  PubMed  Google Scholar 

  41. Kihara M, Yokomise H, Miyauchi A, Matsusaka K. Recovery of parathyroid function after total thyroidectomy. Surg Today. 2000;30:333–8.

    CAS  PubMed  Google Scholar 

  42. Zedenius J, Wadstrom C, Delbridge L. Routine autotransplantation of at least one parathyroid gland during total thyroidectomy may reduce permanent hypoparathyroidism to zero. Aust N Z J Surg. 1999;69:794–7.

    CAS  PubMed  Google Scholar 

  43. El-Sharaky MI, Kahalil MR, Sharaky O, et al. Assessment of parathyroid autotransplantation for preservation of parathyroid function after total thyroidectomy. Head Neck. 2003;25:799–807.

    PubMed  Google Scholar 

  44. Lo C, Lam K. Routine parathyroid autotransplantation during thyroidectomy. Surgery. 2001;129:318–23.

    CAS  PubMed  Google Scholar 

  45. Higgins KM, Mandell DL, Govindaraj S, et al. The role of intraoperative rapid parathyroid hormone monitoring for predicting thyroidectomy-related hypocalcemia. Arch Otolaryngol Head Neck Surg. 2004;130:63–7.

    PubMed  Google Scholar 

  46. Attie JN, Khafif RA, Steckler RM. Elective neck dissection in papillary carcinoma of the thyroid. Am J Surg. 1971;122:464–71.

    CAS  PubMed  Google Scholar 

  47. Machens A, Holzhausen HJ, Dralle H. The prognostic value of primary tumor size in papillary and follicular thyroid carcinoma. Cancer. 2005;103:2269–73.

    PubMed  Google Scholar 

  48. Frankenthaler RA, Sellin RV, Cangir A, Goepfert H. Lymph node metastasis from papillary-follicular thyroid carcinoma in young patients. Am J Surg. 1990;160:341–3.

    CAS  PubMed  Google Scholar 

  49. Lee SH, Lee SS, Jin SM, Kim JH, Rho YS. Predictive factors for central compartment lymph node metastasis in thyroid papillary microcarcinoma. Laryngoscope. 2008;118:659–62.

    PubMed  Google Scholar 

  50. Wada N, Duh QY, Sugino K, et al. Lymph node metastasis from 259 papillary thyroid microcarcinomas: frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection. Ann Surg. 2003;237:399–407.

    PubMed  Google Scholar 

  51. Pereira J, Jimeno J, Miquel J, et al. Nodal yield, ­morbidity, and recurrence after central neck dissection for papillary thyroid carcinoma. Surgery. 2005;138:1095–100.

    PubMed  Google Scholar 

  52. Noguchi S, Noguchi A, Murakami N. Papillary carcinoma of the thyroid. II. Value of prophylactic lymph node excision. Cancer. 1970;26:1061–4.

    CAS  PubMed  Google Scholar 

  53. Carty SE, Cooper DS, Doherty GM, et al. Consensus statement on the terminology and classification of central neck dissection for thyroid cancer. Thyroid. 2009;19:1153–8.

    PubMed  Google Scholar 

  54. Bardet S, Malville E, Rame JP, et al. Macroscopic lymph-node involvement and neck dissection predict lymph-node recurrence in papillary thyroid carcinoma. Eur J Endocrinol. 2008;158:551–60.

    CAS  PubMed  Google Scholar 

  55. White ML, Gauger PG, Doherty GM. Central lymph node dissection in differentiated thyroid cancer. World J Surg. 2007;31:895–904.

    PubMed  Google Scholar 

  56. Sippel RS, Chen H. Controversies in the surgical management of newly diagnosed and recurrent/residual thyroid cancer. Thyroid. 2009;19:1373–80.

    PubMed  Google Scholar 

  57. Shen WT, Ogawa L, Ruan D, et al. Central neck lymph node dissection for papillary thyroid cancer comparison of complication and recurrence rates in 295 initial dissections and reoperations. Arch Surg. 2010;145:272–5.

    PubMed  Google Scholar 

  58. Pederson LC, Shapiro SE, Fritsche HAJ, et al. Potential role for intraoperative gamma probe identification of normal parathyroid glands. Am J Surg. 2003;186:711–7.

    PubMed  Google Scholar 

  59. Alvarado R, Sywak MS, Delbridge L, Sidhu SB. Central lymph node dissection as a secondary procedure for papillary thyroid cancer: Is there added morbidity? Surgery. 2009;145:514–8.

    PubMed  Google Scholar 

  60. Wada N, Suganuma N, Nakayama H, et al. Microscopic regional lymph node status in papillary thyroid carcinoma with and without lymphadenopathy and its relation to outcomes. Langenbecks Arch Surg. 2007;392:417–22.

    PubMed  Google Scholar 

  61. Mirallie E, Visset J, Sagan C, Hamy AL, Bodic MF, Paineau J. Localization of cervical node metastasis of papillary thyroid carcinoma. World J Surg. 1999;23:970–3. discussion 973–974.

    CAS  PubMed  Google Scholar 

  62. Takeyama H, Tabei I, Uchida K, Morikawa T. Sentinel node biopsy for follicular tumours of the thyroid gland. Br J Surg. 2009;96:490–5.

    CAS  PubMed  Google Scholar 

  63. Carcoforo P, Feggi L, Trasforini G, et al. Use of preoperative lymphoscintigraphy and intraoperative gamma-probe detection for identification of the sentinel lymph node in patients with papillary thyroid carcinoma. Eur J Surg Oncol. 2007;33:1075–80. Epub 2007 Mar 1076.

    CAS  PubMed  Google Scholar 

  64. Rettenbacher L, Sungler P, Gmeiner D, Kassmann H, Galvan G. Detecting the sentinel lymph node in patients with differentiated thyroid carcinoma. Eur J Nucl Med. 2000;27:1399–401.

    CAS  PubMed  Google Scholar 

  65. Catarci M, Zaraca F, Angeloni R, et al. Preoperative lymphoscintigraphy and sentinel lymph node biopsy in papillary thyroid cancer. A pilot study. J Surg Oncol. 2001;77:21–4. discussion 25.

    CAS  PubMed  Google Scholar 

  66. Carcoforo P, Sortini D, Soliani G, Basaglia E, Feggi L, Liboni A. Accuracy and reliability of sentinel node biopsy in patients with breast cancer. Single centre study with long term follow-up. Breast Cancer Res Treat. 2006;95:111–6.

    CAS  PubMed  Google Scholar 

  67. Ferlito A, Silver CE, Pelizzo MR, Rinaldo A, Toniato A, Owen RP. Surgical management of the neck in thyroid cancer. ORL J Otorhinolaryngol Relat Spec. 2001;63:63–5.

    CAS  PubMed  Google Scholar 

  68. Dzodic R, Markovic I, Inic M, et al. Sentinel lymph node biopsy may be used to support the decision to perform modified radical neck dissection in differentiated thyroid carcinoma. World J Surg. 2006;30:841–6.

    PubMed  Google Scholar 

  69. Fukui Y, Yamakawa T, Taniki T, Numoto S, Miki H, Monden Y. Sentinel lymph node biopsy in patients with papillary thyroid carcinoma. Cancer. 2001;92:2868–74.

    CAS  PubMed  Google Scholar 

  70. Chow TL, Lim BH, Kwok SP. Sentinel lymph node dissection in papillary thyroid carcinoma. ANZ J Surg. 2004;74:10–2.

    PubMed  Google Scholar 

  71. Arch-Ferrer J, Velazquez D, Fajardo R, Gamboa-Dominguez A, Herrera MF. Accuracy of sentinel lymph node in papillary thyroid carcinoma. Surgery. 2001;130:907–13.

    CAS  PubMed  Google Scholar 

  72. Kelemen PR, Van Herle AJ, Giuliano AE. Sentinel lymphadenectomy in thyroid malignant neoplasms. Arch Surg. 1998;133:288–92.

    CAS  PubMed  Google Scholar 

  73. Dixon E, McKinnon JG, Pasieka JL. Feasibility of sentinel lymph node biopsy and lymphatic mapping in nodular thyroid neoplasms. World J Surg. 2000;24:1396–401.

    CAS  PubMed  Google Scholar 

  74. Lee SK, Choi JH, Lim HI, et al. Sentinel lymph node biopsy in papillary thyroid cancer: comparison study of blue dye method and combined radioisotope and blue dye method in papillary thyroid cancer. Eur J Surg Oncol. 2009;35:974–9.

    CAS  PubMed  Google Scholar 

  75. Silliphant WM, Klinck GH, Levitin MS. Thyroid carcinoma and death. A clinicopathological study of 193 autopsies. Cancer. 1964;17:513–25.

    CAS  PubMed  Google Scholar 

  76. McConahey WM, Hay ID, Woolner LB, van Heerden JA, Taylor WF. Papillary thyroid cancer treated at the Mayo Clinic, 1946 through 1970: initial manifestations, pathologic findings, therapy, and outcome. Mayo Clin Proc. 1986;61:978–96.

    CAS  PubMed  Google Scholar 

  77. McCaffrey JC. Aerodigestive tract invasion by well-differentiated thyroid carcinoma: diagnosis, management, prognosis, and biology. Laryngoscope. 2006;116:1–11.

    PubMed  Google Scholar 

  78. Tuttle RM, Leboeuf R, Martorella AJ. Papillary thyroid cancer: Monitoring and therapy. Endocrinol Metab Clin N Am. 2007;36:753.

    CAS  Google Scholar 

  79. Al-Dhahri SF, Al-Amro AS, Al-Shakwer W, Terkawi AS. Cerebellar mass as a primary presentation of papillary thyroid carcinoma: case report and literature review. Head Neck Oncol. 2009;1:23.

    PubMed Central  PubMed  Google Scholar 

  80. Lee J, Soh EY. Differentiated thyroid carcinoma presenting with distant metastasis at initial diagnosis clinical outcomes and prognostic factors. Ann Surg. 2010;251:114–9.

    PubMed  Google Scholar 

  81. Shaha AR, Ferlito A, Rinaldo A. Distant metastases from thyroid and parathyroid cancer. ORL J Otorhinolaryngol Relat Spec. 2001;63:243–9.

    CAS  PubMed  Google Scholar 

  82. Mihailovic J, Stefanovic L, Malesevic M, Markoski B. The importance of age over radioiodine avidity as a prognostic factor in differentiated thyroid carcinoma with distant metastases. Thyroid. 2009;19:227–32.

    CAS  PubMed  Google Scholar 

  83. Worm AM, Holten I, Taaning E. Nuclear imaging of pulmonary metastases in thyroid carcinoma. Acta Radiol Oncol. 1980;19:401–3.

    CAS  PubMed  Google Scholar 

  84. Fonseca P. Thyroid lung metastasis diagnosed 47 years after thyroidectomy. Ann Thorac Surg. 1999;67:856–7.

    CAS  PubMed  Google Scholar 

  85. Brignardello E, Gallo M, Baldi I, et al. Anaplastic thyroid carcinoma: clinical outcome of 30 consecutive patients referred to a single institution in the past 5 years. Eur J Endocrinol. 2007;156:425–30.

    CAS  PubMed  Google Scholar 

  86. Chen J, Tward JD, Shrieve DC, Hitchcock YJ. Surgery and radiotherapy improves survival in patients with anaplastic thyroid carcinoma: analysis of the surveillance, epidemiology, and end results 1983–2002. Am J Clin Oncol. 2008;31:460–4.

    CAS  PubMed  Google Scholar 

  87. Yau T, Lo CY, Epstein RJ, Lam AKY, Wan KY, Lang BH. Treatment outcomes in anaplastic thyroid ­carcinoma: survival improvement in young patients with localized disease treated by combination of surgery and radiotherapy. Ann Surg Oncol. 2008;15:2500–5.

    PubMed  Google Scholar 

  88. Haq MS, Harmer C. Rare thyroid cancers. In: Mazzaferri EL, Harmer C, Mallick UK, Kendall-Taylor P, editors. Practical management of thyroid cancer. London: Springer; 2006.

    Google Scholar 

  89. Harmer C, Bidmead M, Shepherd S, Sharpe A, Vini L. Radiotherapy planning techniques for thyroid cancer. Br J Radiol. 1998;71:1069–75.

    CAS  PubMed  Google Scholar 

  90. Eeles RA, Fisher C, A’Hern RP, et al. Head and neck sarcomas: prognostic factors and implications for treatment. Br J Cancer. 1993;68:201–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  91. Chen H, Nicol TL, Udelsman R. Clinically significant, isolated metastatic disease to the thyroid gland. World J Surg. 1999;23:177–80. discussion 181.

    CAS  PubMed  Google Scholar 

  92. Shimaoka K, Sokal JE, Pickren JW. Metastatic neoplasms in the thyroid gland. Pathological and clinical findings. Cancer. 1962;15:557–65.

    CAS  PubMed  Google Scholar 

  93. Silverberg SG, Vidone RA. Carcinoma of the thyroid in surgical and postmortem material. Analysis of 300 cases at autopsy and literature review. Ann Surg. 1966;164:291–9.

    CAS  PubMed  Google Scholar 

  94. Ross DS, Litofsky D, Ain KB, et al. Recurrence after treatment of micropapillary thyroid cancer. Thyroid. 2009;19:1043–U1043.

    PubMed  Google Scholar 

  95. Ondik MP, McGinn J, Ruggiero F, Goldenberg D. Unintentional parathyroidectomy and hypoparathyroidism in secondary central compartment surgery for thyroid cancer. Head Neck. 2009;24:24.

    Google Scholar 

  96. Kim MK, Mandel SH, Baloch Z, et al. Morbidity following central compartment reoperation for recurrent or persistent thyroid cancer. Arch Otolaryngol Head Neck Surg. 2004;130:1214–6.

    PubMed  Google Scholar 

  97. Palme CE, Waseem Z, Raza SN, Eski S, Walfish P, Freeman JL. Management and outcome of recurrent well-differentiated thyroid carcinoma. Arch Otolaryngol Head Neck Surg. 2004;130:819–24.

    PubMed  Google Scholar 

  98. Becker WF. Presidential address: pioneers in thyroid surgery. Ann Surg. 1977;185:493–504.

    CAS  PubMed  Google Scholar 

  99. Bhattacharyya N, Fried MP. Assessment of the morbidity and complications of total thyroidectomy. Arch Otolaryngol Head Neck Surg. 2002;128:389–92.

    PubMed  Google Scholar 

  100. Jameson MJ, Levine PA. Complications of thyroid surgery. In: TD J, GC G, editors. Thyroid and parathyroid diseases, Medical and surgical management. New York: Theime; 2009. p. 247–52.

    Google Scholar 

  101. Shaha AR. Revision thyroid surgery – technical ­considerations. Otolaryngol Clin North Am. 2008;41:1169.

    PubMed  Google Scholar 

  102. Rafferty MA, Goldstein DP, Rotstein L, et al. Completion thyroidectomy versus total thyroidectomy: Is there a difference in complication rates? An analysis of 350 patients. J Am Coll Surg. 2007;205:602–7.

    PubMed  Google Scholar 

  103. Tan M, Agarwal G, Reeve T, Barraclough B, Delbridge L. Impact of timing on completion thyroidectomy for thyroid cancer. Br J Surg. 2002;89:802–4.

    CAS  PubMed  Google Scholar 

  104. Kikuchi S, Perrier N, Cheah W, Siperstein A, Duh Q, Clark O. Complication of thyroidectomy in patients with radiation-induced thyroid neoplasms. Arch Surg. 2004;139:1185–8.

    PubMed  Google Scholar 

  105. Seybt MW, Khichi S, Terris DJ. Geriatric thyroidectomy safety of thyroid surgery in an aging population. Arch Otolaryngol Head Neck Surg. 2009;135:1041–4.

    PubMed  Google Scholar 

  106. Mekel M, Stephen AE, Gaz RD, Perry ZH, Hodin RA, Parangi S. Thyroid surgery in octogenarians is associated with higher complication rates. Surgery. 2009;146:913–21.

    PubMed  Google Scholar 

  107. Moo TAS, Umunna B, Kato M, et al. Ipsilateral versus bilateral central neck lymph node dissection in papillary thyroid carcinoma. Ann Surg. 2009;250:403–8.

    PubMed  Google Scholar 

  108. Pieracci FM, Fahey TJ. Substernal thyroidectomy is associated with increased morbidity and mortality as compared with conventional cervical thyroidectomy. J Am Coll Surg. 2007;205:1–7.

    PubMed  Google Scholar 

  109. Shen WT, Kebebew E, Duh QY, Clark OH. Predictors of airway complications after thyroidectomy for ­substernal goiter. Arch Surg. 2004;139:656–9. ­discussion 659–660.

    PubMed  Google Scholar 

  110. Ulmer C, Koch KP, Seimer A, et al. Real-time monitoring of the recurrent laryngeal nerve: an observational clinical trial. Surgery. 2008;143:359–65.

    PubMed  Google Scholar 

  111. Miccoli P, Berti P, Dionigi G, D’Agostino J, Orlandini C, Donatini G. Randomized controlled trial of harmonic scalpel use during thyroidectomy. Arch Otolaryngol Head Neck Surg. 2006;132:1069–73.

    PubMed  Google Scholar 

  112. Siperstein AE, Berber E, Morkoyun E. The use of the harmonic scalpel vs conventional knot tying for vessel ligation in thyroid surgery. Arch Surg. 2002;137:137–42.

    PubMed  Google Scholar 

  113. Koh YW, Park JH, Lee SW, Choi EC. The harmonic scalpel technique without supplementary, ligation in total thyroidectomy with central neck dissection – a prospective randomized study. Ann Surg. 2008;247:945–9.

    PubMed  Google Scholar 

  114. Saint Marc O, Cogliandolo A, Piquard A, Fama F, Pidoto RR. LigaSure vs clamp-and-tie technique to achieve hemostasis in total thyroidectomy for benign multinodular goiter – a prospective randomized study. Arch Surg. 2007;142:150–6.

    PubMed  Google Scholar 

  115. Sinagra D, Montesinos M, Tacchi V, et al. Voice changes after thyroidectomy without recurrent laryngeal nerve injury. J Am Coll Surg. 2004;199:556–60.

    PubMed  Google Scholar 

  116. Musholt TJ, Musholt PB, Garm J, Napiontek U, Keilmann A. Changes of the speaking and singing voice after thyroid or parathyroid surgery. Surgery. 2006;140:978–88. discussion 988–979.

    PubMed  Google Scholar 

  117. Maurer CA. Laryngeal complications after thyroidectomy: is it always the surgeon? (vol 144, pg 149, 2009). Arch Surg. 2009;144:595–5.

    Google Scholar 

  118. Worni M, Schudel HH, Seifert E, et al. Randomized controlled trial on single dose steroid before thyroidectomy for benign disease to improve postoperative nausea, pain, and vocal function. Ann Surg. 2008;248:1060–6.

    PubMed  Google Scholar 

  119. Fewins J, Simpson C, Miller F. Complications of thyroid and parathyroid surgery. Otolaryngol Clin North Am. 2003;36:189–206.

    PubMed  Google Scholar 

  120. Hartl DM, Travagli JP, Leboulleux S, Baudin E, Brasnu DF, Schlumberger M. Clinical review: current concepts in the management of unilateral recurrent laryngeal nerve paralysis after thyroid surgery. J Clin Endocrinol Metab. 2005;90:3084–8.

    CAS  PubMed  Google Scholar 

  121. Bellantone R, Boscherini M, Lombardi CP, et al. Is the identification of the external branch of the superior laryngeal nerve mandatory in thyroid operation? Results of a prospective randomized study. Surgery. 2001;130:1055–9.

    CAS  PubMed  Google Scholar 

  122. Stavrakis AI, Ituarte PHG, Ko CY, Yeh MW. Surgeon volume as a predictor of outcomes in inpatient and outpatient endocrine surgery. Surgery. 2007;142:887–94.

    PubMed  Google Scholar 

  123. McHenry CR. Patient volumes and complications in thyroid surgery. Br J Surg. 2002;89:821–3.

    CAS  PubMed  Google Scholar 

  124. Abboud B, Sleilaty G, Braidy C, et al. Careful examination of thyroid specimen intraoperatively to reduce incidence of inadvertent parathyroidectomy during thyroid surgery. Arch Otolaryngol Head Neck Surg. 2007;133:1105–10.

    PubMed  Google Scholar 

  125. Sasson AR, Pingpank JFJ, Wetherington RW, Hanlon AL, Ridge JA. Incidental parathyroidectomy during thyroid surgery does not cause transient symptomatic hypocalcemia. Arch Otolaryngol Head Neck Surg. 2001;127:304–8.

    CAS  PubMed  Google Scholar 

  126. Sakorafas GH, Stafyla V, Bramis C, Kotsifopoulos N, Kolettis T, Kassaras G. Incidental parathyroidectomy during thyroid surgery: an underappreciated complication of thyroidectomy. World J Surg. 2005;29:1539–43.

    PubMed  Google Scholar 

  127. Gourgiotis S, Moustafellos P, Dimopoulos N, Papaxoinis G, Baratsis S, Hadjiyannakis E. Inadvertent parathyroidectomy during thyroid surgery: the incidence of a complication of thyroidectomy. Langenbecks Arch Surg. 2006;391:557–60.

    PubMed  Google Scholar 

  128. Lam A, Kerr PD. Parathyroid hormone: an early ­predictor of postthyroidectomy hypocalcemia. Laryngoscope. 2003;113:2196–200.

    CAS  PubMed  Google Scholar 

  129. Vescan A, Witterick I, Freeman J. Parathyroid hormone as a predictor of hypocalcemia after thyroidectomy. Laryngoscope. 2005;115:2105–8.

    PubMed  Google Scholar 

  130. Luu Q, Andersen PE, Adams J, Wax MK, Cohen JI. The predictive value of perioperative calcium levels after thyroid/parathyroid surgery. Head Neck. 2002;24:63–7.

    PubMed  Google Scholar 

  131. Gulluoglu BM, Manukyan MN, Cingi A, Yegen C, Yalin R, Aktan AO. Early prediction of normocalcemia after thyroid surgery. World J Surg. 2005;29:1288–93.

    PubMed  Google Scholar 

  132. Payne RJ, Hier MP, Tamilia M, Mac Namara E, Young J, Black MJ. Same-day discharge after total thyroidectomy: the value of 6-hour serum parathyroid hormone and calcium levels. Head Neck. 2005;27:1–7.

    PubMed  Google Scholar 

  133. Samraj K, Gurusamy KS. Wound drains following thyroid surgery. Cochrane Database Syst Rev. 2007;4:CD006099.

    PubMed  Google Scholar 

  134. Avenia N, Sanguinetti A, Cirocchi R, et al. Antibiotic prophylaxis in thyroid surgery: a preliminary multicentric Italian experience. Ann Surg Innov Res. 2009;3:10.

    PubMed Central  PubMed  Google Scholar 

  135. Elaraj D, Sturgeon C. Papillary thyroid carcinoma. In: Morita S, Dackiw A, Zeiger M, editors. Endocrine surgery. New York: McGraw-Hill; 2009. p. 47–64.

    Google Scholar 

  136. McCaffrey JC. Evaluation and treatment of aerodigestive tract invasion by well- differentiated thyroid carcinoma. Cancer Control. 2000;7(3):246–52.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Babak Larian .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Cutter, C.S., Adashek, K.W., Babajanian, M., Larian, B. (2012). Surgical Management of Thyroid Cancer. In: Braunstein, G. (eds) Thyroid Cancer. Endocrine Updates, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0875-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-0875-8_12

  • Published:

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4614-0874-1

  • Online ISBN: 978-1-4614-0875-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics