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Toward a Computationally Unified Behavioral-Economic Model of Addiction

  • E. Terry Mueller
  • Laurence P. Carter
  • Warren K. Bickel
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI, volume 10)

Abstract

This chapter describes an instance of computational constructionism applied to the understanding of drug addiction. Rather than devising models of increasingly smaller anatomical, physiological or chemical units of analysis, the practice exposited here was to expand the integrative scope of behavioral-economic concepts that have been used to describe addiction phenomena. We discussed (a) excessive and persistent consumption of substances, as studied in analysis of demand; and (b) concurrent-choice preference for immediate small and unhealthy reinforcers over delayed but large and healthy reinforcers, and reversals of preference between this two types of alternatives, as studied in the science of delay discounting. While all of these phenomena are characteristic of addiction, it is remarkable how seldom concepts for explaining (a) appear in scientific reports on (b). The notion of expanding the scope of an explanatory concept is introduced via consideration of the concept of unit price. This concept integrates numerous variables traditionally studied in isolation in addiction research, and provides the basis of more general and parsimonious explanations of addiction phenomena. The scope of the unit price concept is further expanded, as it plays a role in a computational formulation describing choice among, and reversals of preference between, concurrently available reinforcers, which are very complex aspects of behavior that are fundamental to addiction phenomena. Lastly, we discuss computational implications and cautions, and scientific and practical prospects that derive from the exercise of expanding the integrative scope of the unit price concept to a broader and more complex range of addiction phenomena. Future developments along these lines are expected to produce constructs with which preferences exhibited by drug-dependent individuals may be predicted more accurately, and may be therapeutically modified.

Keywords

Preference Reversal Demand Curve Unit Price Behavioral Economic Delay Discount 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The writing of this chapter was supported by National Institute on Drug Abuse Grants R37 DA 006526-18, R01 DA 11692-10, R01 DA022386-02, R01 DA024080-01A1, Wilbur Mills Chair Endowment, and in part by the Arkansas Biosciences Institute, a partnership of scientists from Arkansas Children’s Hospital, Arkansas State University, the University of Arkansas-Division of Agriculture, the University of Arkansas, Fayetteville, and the University of Arkansas for Medical Sciences. The Arkansas Biosciences Institute is the major research component of the Tobacco Settlement Proceeds Act of 2000.

References

  1. Ainslie G, Herrnstein RJ (1981) Preference reversal and delayed reinforcement. Anim Learn Behav 9(4):476–482 Google Scholar
  2. Ashton H, Stepney R, Thompson JW (1979) Self-titration by cigarette smokers. Br Med J 2(6186):357–360 PubMedGoogle Scholar
  3. Audrain-McGovern J, Rodriguez D, Epstein LH, Cuevas J, Rodgers K, Wileyto EP (2009) Does delay discounting play an etiological role in smoking or is it a consequence of smoking? Drug Alcohol Depend 103(3):99–106 PubMedGoogle Scholar
  4. Bach PB, Lantos J (1999) Methadone dosing, heroin affordability, and the severity of addiction. Am J Publ Health 89(5):662–665 Google Scholar
  5. Baker F, Johnson MW, Bickel WK (2003) Delay discounting in current and never-before cigarette smokers: Similarities and differences across commodity, sign, and magnitude. J Abnorm Psychol 112(3):382–392 PubMedGoogle Scholar
  6. Benowitz NL, Jacob P, Yu L, Talcott R, Hall S, Jones RT (1986) Reduced tar, nicotine, and carbon monoxide exposure while smoking ultralow- but not low-yield cigarettes. JAMA J Am Med Assoc 256(2):241–246 Google Scholar
  7. Bickel WK, Christensen DR (2010) Behavioral economics of drug addiction. In: Stolerman IP (ed) Encyclopedia of psychopharmacology. Springer, Heidelberg Google Scholar
  8. Bickel WK, DeGrandpre RJ (1995) Price and alternatives: Suggestions for drug policy from psychology. Int J Drug Policy 2:93–105 Google Scholar
  9. Bickel WK, DeGrandpre RJ (1996) Basic psychological science speaks to drug policy: Drug cost and competing reinforcement. In: Bickel WK, DeGrandpre RJ (eds) Drug policy and human nature: Psychological perspectives on the control, prevention and treatment of illicit drug use. Plenum, New York, pp 31–52 Google Scholar
  10. Bickel WK, Marsch LA (2001) Toward a behavioral economic understanding of drug dependence: delay discounting processes. Addiction 96(1):73–86 PubMedGoogle Scholar
  11. Bickel WK, DeGrandpre RJ, Higgins ST, Hughes JR (1990) Behavioral economics of drug self-administration. I. Functional equivalence of response requirement and drug dose. Life Sci 47(17):1501–1510 PubMedGoogle Scholar
  12. Bickel WK, DeGrandpre RJ, Hughes JR, Higgins ST (1991) Behavioral economics of drug self-administration. II. A unit-price analysis of cigarette smoking. J Exp Anal Behav 55(2):145–154 PubMedGoogle Scholar
  13. Bickel WK, Hughes JR, DeGrandpre RJ, Higgins ST, Rizzuto P (1992) Behavioral economics of drug self-administration. IV. The effects of response requirement on the consumption of and interaction between concurrently available coffee and cigarettes. Psychopharmacology (Berl) 107(2–3):211–216 Google Scholar
  14. Bickel WK, DeGrandpre RJ, Higgins ST (1993) Behavioral economics: a novel experimental approach to the study of drug dependence. Drug Alcohol Depend 33(2):173–192 PubMedGoogle Scholar
  15. Bickel WK, DeGrandpre RJ, Higgins ST (1995) The behavioral economics of concurrent drug reinforcers: a review and reanalysis of drug self-administration research. Psychopharmacology (Berl) 118(3):250–259 Google Scholar
  16. Bickel WK, Odum AL, Madden GJ (1999) Impulsivity and cigarette smoking: delay discounting in current, never, and ex-smokers. Psychopharmacology (Berl) 146(4):447–454 Google Scholar
  17. Bickel WK, Pitcock JA, Yi R, Angtuaco EJC (2009) Congruence of BOLD response across intertemporal choice conditions: fictive and real money gains and losses. J Neurosci 29(27):8839–8846 PubMedGoogle Scholar
  18. Bickel WK, Mueller ET, MacKillop J, Yi R (in press). Behavioral economic and neuro-economic perspectives on addiction. In: Sher K (ed) Oxford handbook of substance use disorders. Oxford University Press, New York Google Scholar
  19. Bigelow GE, Griffiths RR, Stitzer ML, Liebson IA (1983) Development of clinical procedures for abuse liability assessment: progress report from the Behavioral Pharmacology Research Unit of the Johns Hopkins University School of Medicine and Baltimore City Hospitals. NIDA Res Monogr 43:125–131 PubMedGoogle Scholar
  20. Bigelow GE, Brooner RK, Silverman K (1998) Competing motivations: drug reinforcement vs non-drug reinforcement. J Psychopharmacol 12(1):8–14 PubMedGoogle Scholar
  21. Bjork JM, Hommer DW, Grant SJ, Danube C (2004) Impulsivity in abstinent alcohol-dependent patients: relation to control subjects and type 1-/type 2-like traits. Alcohol 34(2–3):133–150 PubMedGoogle Scholar
  22. Brandon TH, Tiffany ST, Obremski KM, Baker TB (1990) Postcessation cigarette use: the process of relapse. Addict Behav 15(2):105–114 PubMedGoogle Scholar
  23. Carter LP, Griffiths RR (2009) Principles of laboratory assessment of drug abuse liability and implications for clinical development. Drug Alcohol Depend 105:S14–S25 PubMedGoogle Scholar
  24. Caulkins JP (2001) Drug prices and emergency department mentions for cocaine and heroin. Am J Publ Health 91(9):1446–1448 Google Scholar
  25. Chaloupka FJ, Grossman M, Bickel WK, Saffor M (eds) (1999) The economic analysis of substance use and abuse: An integration of econometric and behavioral economic research. University of Chicago Press, Chicago Google Scholar
  26. Coffey SF, Gudleski GD, Saladin ME, Brady KT (2003) Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals. Exp Clin Psychopharmacol 11(1):18–25 PubMedGoogle Scholar
  27. Collier GH, Johnson DF, Hill WL, Kaufman LW (1986) The economics of the law of effect. J Exp Anal Behav 46(2):113–136 PubMedGoogle Scholar
  28. Corman H, Noonan K, Reichman NE, Dave D (2005) Demand for illicit drugs among pregnant women. Adv Health Econ Health Serv Res 16:41–60 PubMedGoogle Scholar
  29. Creighton DE, Lewis PH (1978) The effect of different cigarettes on human smoking patters. In: Thornton RE (ed) Smoking behavior: physiological and psychological influences. Churchill, Edinburgh Google Scholar
  30. Darke S, Kaye S, Topp L (2002a) Cocaine use in New South Wales, Australia, 1996–2000: 5 year monitoring of trends in price, purity, availability and use from the illicit drug reporting system. Drug Alcohol Depend 67(1):81–88 PubMedGoogle Scholar
  31. Darke S, Topp I, Kaye H, Hall W (2002b) Heroin use in New South Wales, Australia, 1996–2000: 5 year monitoring of trends in price, purity, availability and use from the Illicit Drug Reporting System (IDRS). Addiction 97(2):179–186 PubMedGoogle Scholar
  32. DeGrandpre RJ, Bickel WK, Hughes JR, Higgins ST (1992) Behavioral economics of drug self-administration. III. A reanalysis of the nicotine regulation hypothesis. Psychopharmacology (Berl) 108(1–2):1–10 Google Scholar
  33. DeGrandpre RJ, Bickel WK, Hughes JR, Layng MP, Badger G (1993) Unit price as a useful metric in analyzing effects of reinforcer magnitude. J Exp Anal Behav 60(3):641–666 PubMedGoogle Scholar
  34. Epstein LH, Salvy SJ, Carr KA, Dearing KK, Bickel WK (2010). Food reinforcement, delay discounting and obesity. Phys Behav 100:438–445 Google Scholar
  35. Evans JA (2008) Electronic publication and the narrowing of science and scholarship. Science 321(5887):395–399 PubMedGoogle Scholar
  36. Frith CD (1971) The effect of varying the nicotine content of cigarettes on human smoking behaviour. Psychopharmacologia 19(2):188–192 PubMedGoogle Scholar
  37. Goldfarb T, Gritz ER, Jarvik ME, Stolerman IP (1976) Reactions to cigarettes as a function of nicotine and “tar”. Clin Pharmacol Ther 19(6):767–772 PubMedGoogle Scholar
  38. Green L, Estle SJ (2003a) Preference reversals with food and water reinforcers in rats. J Exp Anal Behav 79(2):233–242 PubMedGoogle Scholar
  39. Green L, Estle SJ (2003b) Preference reversals with food and water reinforcers in rats. J Exp Anal Behav 79(2):233–242 PubMedGoogle Scholar
  40. Green L, Freed DE (1993) The substitutability of reinforcers. J Exp Anal Behav 60(1):141–158 PubMedGoogle Scholar
  41. Green L, Myerson J (1996) Exponential versus hyperbolic discounting of delayed outcomes: Risk and waiting time Google Scholar
  42. Green L, Snyderman M (1980) Choice between rewards differing in amount and delay—toward a choice model of self-control. J Exp Anal Behav 34(2):135–147 PubMedGoogle Scholar
  43. Green L, Fisher EB, Perlow S, Sherman L (1981) Preference reversal and self-control—choice as a function of reward amount and delay. Behav Anal Lett 1(1):43–51 Google Scholar
  44. Green L, Fristoe N, Myerson J (1994) Temporal discounting and preference reversals in choice between delayed outcomes. Psychon Bull Rev 1(3):383–389 Google Scholar
  45. Greenwald MK, Hursh SR (2006) Behavioral economic analysis of opioid consumption in heroin-dependent individuals: Effects of unit price and pre-session drug supply. Drug Alcohol Depend 85(1):35–48 PubMedGoogle Scholar
  46. Griffiths RR, Brady JV, Bradford LD (1979) Predicting abuse liability of drugs with animal drug self-administration procedures: Psychomotor stimulants and hallucinogens. In: Thompson T, Dews PB (eds) Advances in behavioral pharmacology, vol 2. Academic Press, New York Google Scholar
  47. Griffiths RR, Henningfield JE, Bigelow GE (1982) Human cigarette smoking: manipulation of number of puffs per bout, interbout interval and nicotine dose. J Pharmacol Exp Ther 220(2):256–265 PubMedGoogle Scholar
  48. Gritz ER (1980) Smoking behavior and tobacco abuse. In: Mello NK (ed) Advances in substance abuse. JAI Press, Greenwich, pp 91–158 Google Scholar
  49. Gust SW, Pickens RW (1982) Does cigarette nicotine yield affect puff volume? Clin Pharmacol Ther 32(4):418–422 PubMedGoogle Scholar
  50. Haley NJ, Sepkovic DW, Hoffmann D, Wynder EL (1985) Cigarette smoking as a risk for cardiovascular disease. Part VI. Compensation with nicotine availability as a single variable. Clin Pharmacol Ther 38(2):164–170 PubMedGoogle Scholar
  51. Heil SH, Johnson MW, Higgins ST, Bickel WK (2006) Delay discounting in currently using and currently abstinent cocaine-dependent outpatients and non-drug-using matched controls. Addict Behav 31(7):1290–1294 PubMedGoogle Scholar
  52. Henningfield JE (1984) Behavioral pharmacology of cigarette smoking. In: Thompson T, Dews PB, Barrett JE (eds) Advances in behavioral pharmacology, vol 4. Academic Press, Orlando Google Scholar
  53. Henningfield JE, Griffiths RR (1980) Effects of ventilated cigarette holders on cigarette smoking by humans. Psychopharmacology 68(2):115–119 PubMedGoogle Scholar
  54. Heyman GM, Gibb SP (2006) Delay discounting in college cigarette chippers. Behav Pharmacol 17(8):669–679 PubMedGoogle Scholar
  55. Higgins ST, Budney AJ, Bickel WK (1994) Applying behavioral concepts and principles to the treatment of cocaine dependence. Drug Alcohol Depend 34(2):87–97 PubMedGoogle Scholar
  56. Hill P, Marquardt H (1980) Plasma and urine changes after smoking different brands of cigarettes. Clin Pharmacol Ther 27(5):652–658 PubMedGoogle Scholar
  57. Hoffman WF, Moore M, Templin R, McFarland B, Hitzemann RJ, Mitchell SH (2006) Neuropsychological function and delay discounting in methamphetamine-dependent individuals. Psychopharmacology (Berl) 188(2):162–170 Google Scholar
  58. Hoffman WF, Schwartz DL, Huckans MS, McFarland BH, Meiri G, Stevens AA et al. (2008) Cortical activation during delay discounting in abstinent methamphetamine dependent individuals. Psychopharmacology (Berl) 201(2):183–193 Google Scholar
  59. Hursh SR (1978) The economics of daily consumption controlling food- and water-reinforced responding. J Exp Anal Behav 29(3):475–491 PubMedGoogle Scholar
  60. Hursh SR (1980) Economic concepts for the analysis of behavior. J Exp Anal Behav 34(2):219–238 PubMedGoogle Scholar
  61. Hursh SR (1991) Behavioral economics of drug self-administration and drug abuse policy. J Exp Anal Behav 56(2):377–393 PubMedGoogle Scholar
  62. Hursh SR, Silberberg A (2008) Economic demand and essential value. Psychol Rev 115(1):186–198 PubMedGoogle Scholar
  63. Hursh SR, Raslear TG, Shurtleff D, Bauman R, Simmons L (1988) A cost-benefit analysis of demand for food. J Exp Anal Behav 50(3):419–440 PubMedGoogle Scholar
  64. James W (1918) The principles of psychology, vol 1. Holt, New York Google Scholar
  65. Jarvik ME, Popek P, Schneider NG, Baer-Weiss V, Gritz ER (1978) Can cigarette size and nicotine content influence smoking and puffing rates? Psychopharmacology 58(3):303–306 PubMedGoogle Scholar
  66. Johnson MW, Bickel WK (2002) Within-subject comparison of real and hypothetical money rewards in delay discounting. J Exp Anal Behav 77(2):129–146 PubMedGoogle Scholar
  67. Johnson MW, Bickel WK (2003) The behavioral economics of cigarette smoking: The concurrent presence of a substitute and an independent reinforcer. Behav Pharmacol 14(2):137–144 PubMedGoogle Scholar
  68. Johnson MW, Bickel WK, Kirshenbaum AP (2004) Substitutes for tobacco smoking: a behavioral economic analysis of nicotine gum, denicotinized cigarettes, and nicotine-containing cigarettes. Drug Alcohol Depend 74(3):253–264 PubMedGoogle Scholar
  69. Johnson MW, Bickel WK, Baker F (2007a) Moderate drug use and delay discounting: a comparison of heavy, light, and never smokers. Exp Clin Psychopharmacol 15(2):187–194 PubMedGoogle Scholar
  70. Johnson MW, Bickel WK, Baker F (2007b) Moderate drug use and delay discounting: A comparison of heavy, light, and never smokers. Exp Clin Psychopharmacol 15(2):187–194 PubMedGoogle Scholar
  71. Kirby KN, Petry NM (2004) Heroin and cocaine abusers have higher discount rates for delayed rewards than alcoholics or non-drug-using controls. Addiction 99(4):461–471 PubMedGoogle Scholar
  72. Kirby KN, Petry NM, Bickel WK (1999) Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. J Exp Psychol Gen 128(1):78–87 PubMedGoogle Scholar
  73. Kirshenbaum AP, Olsen DM, Bickel WK (2009) A quantitative review of the ubiquitous relapse curve. J Subst Abuse Treat 36(1):8–17 PubMedGoogle Scholar
  74. Ko MC, Terner J, Hursh S, Woods JH, Winger G (2002) Relative reinforcing effects of three opioids with different durations of action. J Pharmacol Exp Ther 301(2):698–704 PubMedGoogle Scholar
  75. Kowal BP, Yi R, Erisman AC, Bickel WK (2007) A comparison of two algorithms in computerized temporal discounting procedures. Behav Process 75(2):231–236 Google Scholar
  76. Krishnan-Sarin S, Reynolds B, Duhig AM, Smith A, Liss T, McFetridge A et al. (2007) Behavioral impulsivity predicts treatment outcome in a smoking cessation program for adolescent smokers. Drug Alcohol Depend 88(1):79–82 PubMedGoogle Scholar
  77. Logue AW, Pena-Correal TE (1985) The effect of food-deprivation on self-control. Behav Process 10(4):355–368 Google Scholar
  78. Longo MC, Henry-Edwards SM, Humeniuk RE, Christie P, Ali RL (2004) Impact of the heroin ‘drought’ on patterns of drug use and drug-related harms. Drug Alcohol Rev 23(2):143–150 PubMedGoogle Scholar
  79. MacKillop J, Kahler CW (2009) Delayed reward discounting predicts treatment response for heavy drinkers receiving smoking cessation treatment. Drug Alcohol Depend 104(3):197–203 PubMedGoogle Scholar
  80. MacKillop J, Murphy JG (2007) A behavioral economic measure of demand for alcohol predicts brief intervention outcomes. Drug Alcohol Depend 89(2–3):227–233 PubMedGoogle Scholar
  81. MacKillop J, Murphy JG, Ray LA, Eisenberg DT, Lisman SA, Lum JK et al. (2008) Further validation of a cigarette purchase task for assessing the relative reinforcing efficacy of nicotine in college smokers. Exp Clin Psychopharmacol 16(1):57–65 PubMedGoogle Scholar
  82. Madden GJ, Petry NM, Badger GJ, Bickel WK (1997) Impulsive and self-control choices in opioid-dependent patients and non-drug-using control participants: drug and monetary rewards. Exp Clin Psychopharmacol 5(3):256–262 PubMedGoogle Scholar
  83. Marlatt GA, Curry S, Gordon JR (1988) A longitudinal analysis of unaided smoking cessation. J Consult Clin Psychol 56(5):715–720 PubMedGoogle Scholar
  84. Mattox AJ, Carroll ME (1996) Smoked heroin self-administration in rhesus monkeys. Psychopharmacology 125(3):195–201 PubMedGoogle Scholar
  85. Mazur JE (1987) An adjusting procedure for studying delayed reinforcement. In: Commons ML, Mazur JE, Nevin JA, Rachlin H (eds) Quantitative analysis of behavior: Vol 5: The effect of delay and of intervening events on reinforcement value. Erlbaum, Hillsdale, pp 55–73 Google Scholar
  86. McMorrow MJ, Foxx RM (1983) Nicotine role in smoking—an analysis of nicotine regulation. Psychol Bull 93(2):302–327 PubMedGoogle Scholar
  87. Mitchell SH (1999) Measures of impulsivity in cigarette smokers and non-smokers. Psychopharmacology (Berl) 146(4):455–464 Google Scholar
  88. Monterosso JR, Ainslie G, Xu JS, Cordova X, Domier CP, London ED (2007) Frontoparietal cortical activity of methamphetamine-dependent and comparison subjects performing a delay discounting task. Hum Brain Mapp 28(5):383–393 PubMedGoogle Scholar
  89. Moss RA, Prue DM (1982) Research on nicotine regulation. Behav Ther 13:31–46 Google Scholar
  90. Mueller ET, Bickel WK (2010). An opportunity cost reinterpretation of preference reversal experiments. Paper present at the 33rd annual meeting of the Society for Quantitative Analysis of Behavior, San Antonio, Texas Google Scholar
  91. Mueller ET, Landes RD, Kowal BP, Yi R, Stitzer ML, Burnett CA et al. (2009) Delay of smoking gratification as a laboratory model of relapse: effects of incentives for not smoking, and relationship with measures of executive function. Behav Pharmacol 20(5–6):461–473 PubMedGoogle Scholar
  92. Mueller ET, Bickel WK, Landes RD (2010) Smoker’s delay discounting indifference points are associated with changes in opportunity-cost-informed price. Paper presented at the 72nd annual meeting of the college on problems of drug dependence, Scottsdale, Arizona Google Scholar
  93. Murphy JG, MacKillop J (2006) Relative reinforcing efficacy of alcohol among college student drinkers. Exp Clin Psychopharmacol 14(2):219–227 PubMedGoogle Scholar
  94. Navarick DJ, Fantino E (1976) Self-control and general models of choice. J Exp Psychol, Anim Behav Processes 2(1):75–87 Google Scholar
  95. Nides MA, Rakos RF, Gonzales D, Murray RP, Tashkin DP, Bjornson-Benson WM et al. (1995) Predictors of initial smoking cessation and relapse through the first 2 years of the lung health study. J Consult Clin Psychol 63(1):60–69 PubMedGoogle Scholar
  96. Norregaard J, Tonnesen P, Petersen L (1993) Predictors and reasons for relapse in smoking cessation with nicotine and placebo patches. Prev Med 22(2):261–271 PubMedGoogle Scholar
  97. Odum AL, Madden GJ, Badger GJ, Bickel WK (2000) Needle sharing in opioid-dependent outpatients: psychological processes underlying risk. Drug Alcohol Depend 60(3):259–266 PubMedGoogle Scholar
  98. Ohmura Y, Takahashi T, Kitamura N (2005) Discounting delayed and probabilistic monetary gains and losses by smokers of cigarettes. Psychopharmacology (Berl) 182(4):508–515 Google Scholar
  99. Petry NM (2001) Delay discounting of money and alcohol in actively using alcoholics, currently abstinent alcoholics, and controls. Psychopharmacology (Berl) 154(3):243–250 Google Scholar
  100. Rachlin H, Green L (1972a) Commitement, choice, and self-control. J Exp Anal Behav 17:15–72 PubMedGoogle Scholar
  101. Rachlin H, Green L (1972b) Commitment, choice and self-control. J Exp Anal Behav 17(1):15 PubMedGoogle Scholar
  102. Rachlin H, Battalio R, Kagel J, Green L (1981) Maximization theory in behavioral psychology. Behav Brain Sci 4(3):371–388 Google Scholar
  103. Raslear TG, Bauman RA, Hursh SR, Shurtleff D, Simmons L (1988) Rapid demand curves for behavioral economics. Anim Learn Behav 16(3):330–339 Google Scholar
  104. Reynolds B, Leraas K, Collins C, Melanko S (2009) Delay discounting by the children of smokers and nonsmokers. Drug Alcohol Depend 99(1–3):350–353 PubMedGoogle Scholar
  105. Russell MA, Wilson C, Patel UA, Cole PV, Feyerabend C (1973) Comparison of effect on tobacco consumption and carbon monoxide absorption of changing to high and low nicotine cigarettes. Br Med J 4(5891):512–516 PubMedGoogle Scholar
  106. Russell MA, Wilson C, Patel UA, Feyerabend C, Cole PV (1975) Plasma nicotine levels after smoking cigarettes with high, medium, and low nicotine yields. Br Med J 2(5968):414–416 PubMedGoogle Scholar
  107. Russell MA, Sutton SR, Feyerabend C, Saloojee Y (1980) Smokers’ response to shortened cigarettes: dose reduction without dilution of tobacco smoke. Clin Pharmacol Ther 27(2):210–218 PubMedGoogle Scholar
  108. Schifano F, Corkery J (2008) Cocaine/crack cocaine consumption, treatment demand, seizures, related offences, prices, average purity levels and deaths in the UK (1990–2004). J Psychopharmacol 22(1):71–79 PubMedGoogle Scholar
  109. Schifano F, Corkery J, Deluca P, Oyefeso A, Ghodse AH (2006) Ecstasy (MDMA, MDA, MDEA, MBDB) consumption, seizures, related offences, prices, dosage levels and deaths in the UK (1994–2003). J Psychopharmacol 20(3):456–463 PubMedGoogle Scholar
  110. Schuster CR, Thompson T (1969) Self administration and behavioral dependence on drugs. Annu Rev Pharmacol 9(1):483–502 PubMedGoogle Scholar
  111. Shahan TA, Bickel WK, Badger GJ, Giordano LA (2001) Sensitivity of nicotine-containing and de-nicotinized cigarette consumption to alternative non-drug reinforcement: a behavioral economic analysis. Behav Pharmacol 12(4):277–284 PubMedGoogle Scholar
  112. Shahan TA, Odum AL, Bickel WK (2000) Nicotine gum as a substitute for cigarettes: a behavioral economic analysis. Behav Pharmacol 11(1):71–79 PubMedGoogle Scholar
  113. Shiffman S, Paty JA, Gnys M, Kassel JA, Hickcox M (1996) First lapses to smoking: within-subjects analysis of real-time reports. J Consult Clin Psychol 64(2):366–379 PubMedGoogle Scholar
  114. Silverman K (2004) Exploring the limits and utility of operant conditioning in the treatment of drug addiction. Behav Anal 27(2):209–230 Google Scholar
  115. Skurvydas A (2005) New methodology in biomedical science: methodological errors in classical science. Medicina (Kaunas) 41(1):7–16 Google Scholar
  116. Snyderman M (1983) Delay and amount of reward in a concurrent chain. J Exp Anal Behav 39(3):437–447 PubMedGoogle Scholar
  117. Soto AM, Sonnenschein C (2005) Emergentism as a default: cancer as a problem of tissue organization. J Biosci 30(1):103–118 PubMedGoogle Scholar
  118. Stepney R (1981) Would a medium-nicotine, low-tar cigarette be less hazardous to health? Br Med J (Clin Res Ed) 283(6302):1292–1296 Google Scholar
  119. Strange K (2005) The end of “naive reductionism”: rise of systems biology or renaissance of physiology?. Am J Physiol, Cell Physiol 288(5):C968–C974 PubMedGoogle Scholar
  120. Turner JA, Sillett RW, Ball KP (1974) Some effects of changing to low-tar and low-nicotine cigarettes. Lancet 2(7883):737–739 PubMedGoogle Scholar
  121. Vuchinich RE, Simpson CA (1998) Hyperbolic temporal discounting in social drinkers and problem drinkers. Exp Clin Psychopharmacol 6(3):292–305 PubMedGoogle Scholar
  122. Westman EC, Behm FM, Simel DL, Rose JE (1997) Smoking behavior on the first day of a quit attempt predicts long-term abstinence. Arch Intern Med 157(3):335–340 PubMedGoogle Scholar
  123. Winger G, Galuska CM, Hursh SR, Woods JH (2006) Relative reinforcing effects of cocaine, remifentanil, and their combination in rhesus monkeys. J Pharmacol Exp Ther 318(1):223–229 PubMedGoogle Scholar
  124. Yoon JH, Higgins ST, Heil SH, Sugarbaker RJ, Thomas CS, Badger GJ (2007) Delay discounting predicts postpartum relapse to cigarette smoking among pregnant women. Exp Clin Psychopharmacol 15(2):176–186 PubMedGoogle Scholar
  125. Zacny JP, Stitzer ML (1988) Cigarette brand-switching: effects on smoke exposure and smoking behavior. J Pharmacol Exp Ther 246(2):619–627 PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • E. Terry Mueller
    • 1
  • Laurence P. Carter
    • 2
  • Warren K. Bickel
    • 3
  1. 1.Advanced Recovery Research Center, Virginia Tech Carilion Research InstituteVirginia TechRoanokeUSA
  2. 2.Center for Addiction Research, Psychiatric Research InstituteUniversity of Arkansas for Medical SciencesLittle RockUSA
  3. 3.Advanced Recovery Research Center, Virginia Tech Carilion Research Institute and Department of PsychologyVirginia TechRoanokeUSA

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