Long-Term Outcome of Chronic Dialysis in Children

Chapter

Abstract

As the prevalence of children on renal replacement therapy (RRT) increases worldwide and comprises at least 2% of any national dialysis or transplant programme, it is essential that paediatric nephrologists are able to advise families on the possible outcome for their child with end-stage renal disease (ESRD). Most children start dialysis with the expectation that a successful renal transplant is an achievable goal and will provide the best survival and quality of life. However, some will require long-term dialysis or may return intermittently to dialysis during the course of their chronic kidney disease (CKD) management. This chapter reviews the available outcome data for children on chronic dialysis along with data from the larger adult dialysis experience to inform our paediatric practise. The multiple factors that may influence outcome and particularly those which can potentially be modified are discussed.

Keywords

Chronic dialysis Children Long term outcomes Pediatric dialysis 

References

  1. 1.
    US Renal Data System. The Concise 2009 Annual Data Report: National Institutes of Health, National Institutes of Diabetes and Digestive and Kidney Diseases, Bathesda, MD; 2009.Google Scholar
  2. 2.
    North American Pediatric Renal Trials and Collaborative Studies. NAPRTCS Annual Report: renal transplantation, dialysis, chronic renal insufficiency, 2008.Google Scholar
  3. 3.
    McDonald SP, Craig JC. Long-term survival of children with end-stage renal disease. N Engl J Med. 2004;350(26):2654–62.PubMedGoogle Scholar
  4. 4.
    Groothoff JW, Gruppen MP, Offringa M, et al. Mortality and causes of death of end-stage renal disease in children: a Dutch cohort study. Kidney Int. 2002;61(2):621–9.PubMedGoogle Scholar
  5. 5.
    UNOS. 2002 Annual report of the US scientific registry of transplant recipients and the organ procurement and transplantation network; transplant data 1992–2001: United Network for organ sharing, Rockville, MD; 2007.Google Scholar
  6. 6.
    Hijazi R, Abitbol CL, Chandar J, Seeherunvong W, Freundlich M, Zilleruelo G. Twenty-five years of infant dialysis: a single center experience. J Pediatr. 2009;155(1):111–7.PubMedGoogle Scholar
  7. 7.
    Kramer A, Stel VS, Tizard J, et al. Characteristics and survival of young adults who started renal replacement therapy during childhood. Nephrol Dial Transplant. 2009;24(3):926–33.PubMedGoogle Scholar
  8. 8.
    ERA-EDTA Registry. ERA-EDTA Registry 2005 annual report. Amsterdam, the Netherlands: Academic Medical Center; 2005.Google Scholar
  9. 9.
    Carey WA, Talley LI, Sehring SA, Jaskula JM, Mathias RS. Outcomes of dialysis initiated during the neonatal period for treatment of end-stage renal disease: a North American Pediatric Renal Trials and Collaborative Studies special analysis. Pediatrics. 2007;119(2):e468–73.PubMedGoogle Scholar
  10. 10.
    Rheault MN, Rajpal J, Chavers B, Nevins TE. Outcomes of infants <28 days old treated with peritoneal dialysis for end-stage renal disease. Pediatr Nephrol. 2009;24(10):2035–9.PubMedGoogle Scholar
  11. 11.
    Geary DF. Attitudes of pediatric nephrologists to management of end-stage renal disease in infants. J Pediatr. 1998;133(1):154–6.PubMedGoogle Scholar
  12. 12.
    Shroff R, Rees L, Trompeter R, Hutchinson C, Ledermann S. Long-term outcome of chronic dialysis in children. Pediatr Nephrol. 2006;21(2): 257–64.PubMedGoogle Scholar
  13. 13.
    Ansell D, Feehaly J, Fogarty D, Tomson C, Wiliams A, Warwick G. UK Renal Registry Report. Bristol, UK, 2008.Google Scholar
  14. 14.
    Oh J, Wunsch R, Turzer M, et al. Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. Circulation. 2002; 106(1):100–5.PubMedGoogle Scholar
  15. 15.
    Verrina E, Edefonti A, Gianoglio B, et al. A multicenter experience on patient and technique survival in children on chronic dialysis. Pediatr Nephrol. 2004;19(1):82–90.PubMedGoogle Scholar
  16. 16.
    Wong CS, Hingorani S, Gillen DL, et al. Hypoalbuminemia and risk of death in pediatric patients with end-stage renal disease. Kidney Int. 2002;61(2):630–7.PubMedGoogle Scholar
  17. 17.
    Wood EG, Hand M, Briscoe DM, et al. Risk factors for mortality in infants and young children on dialysis. Am J Kidney Dis. 2001;37(3):573–9.PubMedGoogle Scholar
  18. 18.
    Ledermann SE, Scanes ME, Fernando ON, Duffy PG, Madden SJ, Trompeter RS. Long-term outcome of peritoneal dialysis in infants. J Pediatr. 2000; 136(1):24–9.PubMedGoogle Scholar
  19. 19.
    Ellis EN, Pearson D, Champion B, Wood EG. Outcome of infants on chronic peritoneal dialysis. Adv Perit Dial. 1995;11:266–9.PubMedGoogle Scholar
  20. 20.
    Shroff R, Wright E, Ledermann S, Hutchinson C, Rees L. Chronic hemodialysis in infants and children under 2 years of age. Pediatr Nephrol. 2003; 18(4):378–83.PubMedGoogle Scholar
  21. 21.
    Mekahli D, Shaw V, Ledermann SE, Rees L. Long-term outcome of Infants with severe chronic kidney disease. Clin J Am Soc Nephrol. 2010;5(1):10–7.PubMedGoogle Scholar
  22. 22.
    Taghizadeh AK, Desai D, Ledermann SE, et al. Renal transplantation or bladder augmentation first? A comparison of complications and outcomes in children. BJU Int. 2007;100(6):1365–70.PubMedGoogle Scholar
  23. 23.
    Leonard MB, Donaldson LA, Ho M, Geary DF. A prospective cohort study of incident maintenance dialysis in children: an NAPRTC study. Kidney Int. 2003;63(2):744–55.PubMedGoogle Scholar
  24. 24.
    North American Pediatric Renal Trials and Collaborative Studies. NAPRTCS Annual Report: renal transplantation, dialysis, chronic renal insufficiency, 2006.Google Scholar
  25. 25.
    Renal Association. Treatment of adults and children with renal failure: standards and audit measures, 2002.Google Scholar
  26. 26.
    NKF-DOQI. NKF-DOQI: Clinical practice guidelines and clinical practice recommendations for pediatrics 2006 updates: hemodialysis adequacy, peritoneal dialysis adequacy and vascular access, 2006.Google Scholar
  27. 27.
    Fischbach M, Edefonti A, Schroder C, Watson A. Hemodialysis in children: general practical guidelines. Pediatr Nephrol. 2005;20(8):1054–66.PubMedGoogle Scholar
  28. 28.
    Pastan S, Soucie JM, McClellan WM. Vascular access and increased risk of death among hemodialysis patients. Kidney Int. 2002;62(2):620–6.PubMedGoogle Scholar
  29. 29.
    Sheth RD, Brandt ML, Brewer ED, Nuchtern JG, Kale AS, Goldstein SL. Permanent hemodialysis vascular access survival in children and adolescents with end-stage renal disease. Kidney Int. 2002;62(5): 1864–9.PubMedGoogle Scholar
  30. 30.
    Ramage IJ, Bailie A, Tyerman KS, McColl JH, Pollard SG, Fitzpatrick MM. Vascular access survival in children and young adults receiving long-term hemodialysis. Am J Kidney Dis. 2005;45(4):708–14.PubMedGoogle Scholar
  31. 31.
    White CT, Gowrishankar M, Feber J, Yiu V. Clinical practice guidelines for pediatric peritoneal dialysis. Pediatr Nephrol. 2006;21(8):1059–66.PubMedGoogle Scholar
  32. 32.
    Rumpsfeld M, McDonald SP, Johnson DW. Higher peritoneal transport status is associated with higher mortality and technique failure in the Australian and New Zealand peritoneal dialysis patient populations. J Am Soc Nephrol. 2006;17(1):271–8.PubMedGoogle Scholar
  33. 33.
    Brimble KS, Walker M, Margetts PJ, Kundhal KK, Rabbat CG. Meta-analysis: peritoneal membrane transport, mortality, and technique failure in peritoneal dialysis. J Am Soc Nephrol. 2006;17(9):2591–8.PubMedGoogle Scholar
  34. 34.
    Andreoli SP, Leiser J, Warady BA, Schlichting L, Brewer ED, Watkins SL. Adverse effect of peritonitis on peritoneal membrane function in children on dialysis. Pediatr Nephrol. 1999;13(1):1–6.PubMedGoogle Scholar
  35. 35.
    Davies SJ, Brown EA, Frandsen NE, et al. Longitudinal membrane function in functionally anuric patients treated with APD: data from EAPOS on the effects of glucose and icodextrin prescription. Kidney Int. 2005;67(4):1609–15.PubMedGoogle Scholar
  36. 36.
    Honda M, Warady BA. Long-term peritoneal dialysis and encapsulating peritoneal sclerosis in children. Pediatr Nephrol. 2010;25(1):75–81.Google Scholar
  37. 37.
    Eknoyan G, Beck GJ, Cheung AK, et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med. 2002;347(25):2010–9.PubMedGoogle Scholar
  38. 38.
    Gorman G, Furth S, Hwang W, et al. Clinical outcomes and dialysis adequacy in adolescent hemodialysis patients. Am J Kidney Dis. 2006;47(2):285–93.PubMedGoogle Scholar
  39. 39.
    Tom A, McCauley L, Bell L, et al. Growth during maintenance hemodialysis: impact of enhanced nutrition and clearance. J Pediatr. 1999;134(4):464–71.PubMedGoogle Scholar
  40. 40.
    Fischbach M, Terzic J, Menouer S, et al. Intensified and daily hemodialysis in children might improve statural growth. Pediatr Nephrol. 2006;21(11): 1746–52.PubMedGoogle Scholar
  41. 41.
    Pauly RP, Gill JS, Rose CL, et al. Survival among nocturnal home haemodialysis patients compared to kidney transplant recipients. Nephrol Dial Transplant. 2009;24(9):2915–9.PubMedGoogle Scholar
  42. 42.
    Chan CT. Cardiovascular effects of home intensive hemodialysis. Adv Chronic Kidney Dis. 2009;16(3): 173–8.PubMedGoogle Scholar
  43. 43.
    Canaud B, Bragg-Gresham JL, Marshall MR, et al. Mortality risk for patients receiving hemodiafiltration versus hemodialysis: European results from the DOPPS. Kidney Int. 2006;69(11):2087–93.PubMedGoogle Scholar
  44. 44.
    Jirka T, Cesare S, Di Benedetto A, et al. Mortality risk for patients receiving hemodiafiltration versus hemodialysis. Kidney Int. 2006;70(8):1524. author reply 1524–1525.PubMedGoogle Scholar
  45. 45.
    Lo WK, Lui SL, Chan TM, et al. Minimal and optimal peritoneal Kt/V targets: results of an anuric peritoneal dialysis patient’s survival analysis. Kidney Int. 2005;67(5):2032–8.PubMedGoogle Scholar
  46. 46.
    Lo WK, Ho YW, Li CS, et al. Effect of Kt/V on survival and clinical outcome in CAPD patients in a randomized prospective study. Kidney Int. 2003; 64(2):649–56.PubMedGoogle Scholar
  47. 47.
    Paniagua R, Amato D, Vonesh E, et al. Effects of increased peritoneal clearances on mortality rates in peritoneal dialysis: ADEMEX, a prospective, randomized, controlled trial. J Am Soc Nephrol. 2002;13(5):1307–20.PubMedGoogle Scholar
  48. 48.
    Jansen MA, Termorshuizen F, Korevaar JC, Dekker FW, Boeschoten E, Krediet RT. Predictors of survival in anuric peritoneal dialysis patients. Kidney Int. 2005;68(3):1199–205.PubMedGoogle Scholar
  49. 49.
    Brem AS, Lambert C, Hill C, Kitsen J, Shemin DG. Clinical morbidity in pediatric dialysis patients: data from the network 1 clinical indicators project. Pediatr Nephrol. 2001;16(11):854–7.PubMedGoogle Scholar
  50. 50.
    Brem AS, Lambert C, Hill C, Kitsen J, Shemin DG. Outcome data on pediatric dialysis patients from the end-stage renal disease clinical indicators project. Am J Kidney Dis. 2000;36(2):310–7.PubMedGoogle Scholar
  51. 51.
    Rumpsfeld M, McDonald SP, Johnson DW. Peritoneal small solute clearance is nonlinearly related to patient survival in the Australian and New Zealand peritoneal dialysis patient populations. Perit Dial Int. 2009;29(6):637–46.PubMedGoogle Scholar
  52. 52.
    Perl J, Bargman JM. The importance of residual kidney function for patients on dialysis: a critical review. Am J Kidney Dis. 2009;53(6):1068–81.PubMedGoogle Scholar
  53. 53.
    Canada-USA (CANUSA). Peritoneal Dialysis Study Group. Adequacy of dialysis and nutrition in continuous peritoneal dialysis: association with clinical outcomes. J Am Soc Nephrol. 1996;7(2):198–207.Google Scholar
  54. 54.
    Bargman JM, Thorpe KE, Churchill DN. Relative contribution of residual renal function and peritoneal clearance to adequacy of dialysis: a reanalysis of the CANUSA study. J Am Soc Nephrol. 2001;12(10): 2158–62.PubMedGoogle Scholar
  55. 55.
    Chadha V, Blowey DL, Warady BA. Is growth a valid outcome measure of dialysis clearance in children undergoing peritoneal dialysis? Perit Dial Int. 2001;21(Suppl 3):S179–84.PubMedGoogle Scholar
  56. 56.
    Konings CJ, Kooman JP, Gladziwa U, van der Sande FM, Leunissen KM. A decline in residual glomerular filtration during the use of icodextrin may be due to underhydration. Kidney Int. 2005;67(3):1190–1.PubMedGoogle Scholar
  57. 57.
    Medcalf JF, Harris KP, Walls J. Role of diuretics in the preservation of residual renal function in patients on continuous ambulatory peritoneal dialysis. Kidney Int. 2001;59(3):1128–33.PubMedGoogle Scholar
  58. 58.
    Li PK, Chow KM, Wong TY, Leung CB, Szeto CC. Effects of an angiotensin-converting enzyme inhibitor on residual renal function in patients receiving peritoneal dialysis. A randomized, controlled study. Ann Intern Med. 2003;139(2):105–12.PubMedGoogle Scholar
  59. 59.
    Suzuki H, Kanno Y, Sugahara S, Okada H, Nakamoto H. Effects of an angiotensin II receptor blocker, valsartan, on residual renal function in patients on CAPD. Am J Kidney Dis. 2004;43(6):1056–64.PubMedGoogle Scholar
  60. 60.
    Fang W, Oreopoulos DG, Bargman JM. Use of ACE inhibitors or angiotensin receptor blockers and survival in patients on peritoneal dialysis. Nephrol Dial Transplant. 2008;23(11):3704–10.PubMedGoogle Scholar
  61. 61.
    The Escape Trial Group. Strict blood-pressure control and progression of renal failure in children. N Engl J Med. 2009;361(17%U http://content.nejm.org/cgi/content/abstract/361/17/1639%8 October 22, 2009):1639–50.Google Scholar
  62. 62.
    de Brito-Ashurst I, Varagunam M, Raftery MJ, Yaqoob MM. Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol. 2009;20(9):2075–84.PubMedGoogle Scholar
  63. 63.
    Rees L, Shaw V. Nutrition in children with CRF and on dialysis. Pediatr Nephrol. 2007;22(10):1689–702.PubMedGoogle Scholar
  64. 64.
    Amaral S, Hwang W, Fivush B, Neu A, Frankenfield D, Furth S. Serum albumin level and risk for mortality and hospitalization in adolescents on hemodialysis. Clin J Am Soc Nephrol. 2008;3(3):759–67.PubMedGoogle Scholar
  65. 65.
    Norman LJ, Coleman JE, Macdonald IA, Tomsett AM, Watson AR. Nutrition and growth in relation to severity of renal disease in children. Pediatr Nephrol. 2000;15(3–4):259–65.PubMedGoogle Scholar
  66. 66.
    Wong CS, Gipson DS, Gillen DL, et al. Anthropometric measures and risk of death in children with end-stage renal disease. Am J Kidney Dis. 2000;36(4):811–9.PubMedGoogle Scholar
  67. 67.
    Furth SL, Stablein D, Fine RN, Powe NR, Fivush BA. Adverse clinical outcomes associated with short stature at dialysis initiation: a report of the North American Pediatric Renal Transplant Cooperative Study. Pediatrics. 2002;109(5):909–13.PubMedGoogle Scholar
  68. 68.
    Kari JA, Gonzalez C, Ledermann SE, Shaw V, Rees L. Outcome and growth of infants with severe chronic renal failure. Kidney Int. 2000;57(4):1681–7.PubMedGoogle Scholar
  69. 69.
    Holtta T, Ronnholm K, Jalanko H, Holmberg C. Clinical outcome of pediatric patients on peritoneal dialysis under adequacy control. Pediatr Nephrol. 2000;14(10–11):889–97.PubMedGoogle Scholar
  70. 70.
    Cansick J, Waller S, Ridout D, Rees L. Growth and PTH in prepubertal children on long-term dialysis. Pediatr Nephrol. 2007;22(9):1349–54.PubMedGoogle Scholar
  71. 71.
    Seikaly MG, Salhab N, Warady BA, Stablein D. Use of rhGH in children with chronic kidney disease: lessons from NAPRTCS. Pediatr Nephrol. 2007;22(8):1195–204.PubMedGoogle Scholar
  72. 72.
    Groothoff JW, Grootenhuis M, Dommerholt A, Gruppen MP, Offringa M, Heymans HS. Impaired cognition and schooling in adults with end stage renal disease since childhood. Arch Dis Child. 2002; 87(5):380–5.PubMedGoogle Scholar
  73. 73.
    Bawden HN, Acott P, Carter J, et al. Neuropsychological functioning in end-stage renal disease. Arch Dis Child. 2004;89(7):644–7.PubMedGoogle Scholar
  74. 74.
    Goldstein SL, Graham N, Burwinkle T, Warady B, Farrah R, Varni JW. Health-related quality of life in pediatric patients with ESRD. Pediatr Nephrol. 2006;21(6):846–50.PubMedGoogle Scholar
  75. 75.
    McKenna AM, Keating LE, Vigneux A, Stevens S, Williams A, Geary DF. Quality of life in children with chronic kidney disease-patient and caregiver assessments. Nephrol Dial Transplant. 2006;21(7): 1899–905.PubMedGoogle Scholar
  76. 76.
    Groothoff JW, Grootenhuis MA, Offringa M, Stronks K, Hutten GJ, Heymans HS. Social consequences in adult life of end-stage renal disease in childhood. J Pediatr. 2005;146(4):512–7.PubMedGoogle Scholar
  77. 77.
    Goldstein SL, Rosburg NM, Warady BA, et al. Pediatric end stage renal disease health-related quality of life differs by modality: a PedsQL ESRD analysis. Pediatr Nephrol. 2009;24(8):1553–60.PubMedGoogle Scholar
  78. 78.
    Foley RN, Parfrey PS, Sarnak MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis. 1998;32(5 Suppl 3):S112–9.PubMedGoogle Scholar
  79. 79.
    Parekh RS, Carroll CE, Wolfe RA, Port FK. Cardiovascular mortality in children and young adults with end-stage kidney disease. J Pediatr. 2002;141(2):191–7.PubMedGoogle Scholar
  80. 80.
    Litwin M, Wuhl E, Jourdan C, et al. Altered morphologic properties of large arteries in children with chronic renal failure and after renal transplantation. J Am Soc Nephrol. 2005;16(5):1494–500.PubMedGoogle Scholar
  81. 81.
    Chavers BM, Li S, Collins AJ, Herzog CA. Cardiovascular disease in pediatric chronic dialysis patients. Kidney Int. 2002;62(2):648–53.PubMedGoogle Scholar
  82. 82.
    Goldsmith D, Ritz E, Covic A. Vascular calcification: a stiff challenge for the nephrologist: does preventing bone disease cause arterial disease? Kidney Int. 2004;66(4):1315–33.PubMedGoogle Scholar
  83. 83.
    Block GA, Hulbert-Shearon TE, Levin NW, Port FK. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis. 1998;31(4):607–17.PubMedGoogle Scholar
  84. 84.
    Shroff RC, Donald AE, Hiorns MP, et al. Mineral metabolism and vascular damage in children on dialysis. J Am Soc Nephrol. 2007;18(11):2996–3003.PubMedGoogle Scholar
  85. 85.
    Shanahan CM. Vascular calcification – a matter of damage limitation? Nephrol Dial Transplant. 2006;21(5):1166–9.PubMedGoogle Scholar
  86. 86.
    Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial. 2007;20(2):103–9.PubMedGoogle Scholar
  87. 87.
    Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM. The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int. 2002;62(5):1524–38.PubMedGoogle Scholar
  88. 88.
    Nikolov I, Joki N, Drueke T, Massy Z. Beyond ­phosphate – role of uraemic toxins in cardiovascular calcification. Nephrol Dial Transplant. 2006;21(12): 3354–7.PubMedGoogle Scholar
  89. 89.
    Bennett-Richards K, Kattenhorn M, Donald A, et al. Does oral folic acid lower total homocysteine levels and improve endothelial function in children with chronic renal failure? Circulation. 2002;105(15): 1810–5.PubMedGoogle Scholar
  90. 90.
    Bennett-Richards KJ, Kattenhorn M, Donald AE, et al. Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure. Kidney Int. 2002;62(4):1372–8.PubMedGoogle Scholar
  91. 91.
    Sarafidis PA, Bakris GL. Microalbuminuria and chronic kidney disease as risk factors for cardiovascular disease. Nephrol Dial Transplant. 2006;21(9): 2366–74.PubMedGoogle Scholar
  92. 92.
    Querfeld U, Salusky IB, Nelson P, Foley J, Fine RN. Hyperlipidemia in pediatric patients undergoing peritoneal dialysis. Pediatr Nephrol. 1988;2(4):447–52.PubMedGoogle Scholar
  93. 93.
    Mitsnefes MM. Cardiovascular morbidity and mortality in children with chronic kidney disease in North America: lessons from the USRDS and NAPRTCS databases. Perit Dial Int. 2005;25(Suppl 3):S120–2.PubMedGoogle Scholar
  94. 94.
    Mitsnefes MM. Hypertension in children and ­adolescents. Pediatr Clin North Am. 2006;53(3): 493–512. viii.PubMedGoogle Scholar
  95. 95.
    Wilson AC, Mitsnefes MM. Cardiovascular disease in CKD in children: update on risk factors, risk assessment, and management. Am J Kidney Dis. 2009;54(2):345–60.PubMedGoogle Scholar
  96. 96.
    Kari JA, Donald AE, Vallance DT, et al. Physiology and biochemistry of endothelial function in children with chronic renal failure. Kidney Int. 1997;52(2): 468–72.PubMedGoogle Scholar
  97. 97.
    Blacher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, London GM. Impact of aortic stiffness on survival in end-stage renal disease. Circulation. 1999;99(18):2434–9.PubMedGoogle Scholar
  98. 98.
    London GM, Guerin AP, Marchais SJ, Metivier F, Pannier B, Adda H. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant. 2003;18(9):1731–40.PubMedGoogle Scholar
  99. 99.
    Goodman WG, London G, Amann K, et al. Vascular calcification in chronic kidney disease. Am J Kidney Dis. 2004;43(3):572–9.PubMedGoogle Scholar
  100. 100.
    Lerner GR, Warady BA, Sullivan EK, Alexander SR. Chronic dialysis in children and adolescents. The 1996 annual report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol. 1999;13(5):404–17.PubMedGoogle Scholar
  101. 101.
    Leypoldt JK, Cheung AK, Delmez JA, et al. Relationship between volume status and blood pressure during chronic hemodialysis. Kidney Int. 2002;61(1):266–75.PubMedGoogle Scholar
  102. 102.
    Lingens N, Soergel M, Loirat C, Busch C, Lemmer B, Scharer K. Ambulatory blood pressure monitoring in paediatric patients treated by regular haemodialysis and peritoneal dialysis. Pediatr Nephrol. 1995;9(2):167–72.PubMedGoogle Scholar
  103. 103.
    Chavers BM, Solid CA, Daniels FX, et al. Hypertension in pediatric long-term hemodialysis patients in the United States. Clin J Am Soc Nephrol. 2009;4(8):1363–9.PubMedGoogle Scholar
  104. 104.
    Klassen PS, Lowrie EG, Reddan DN, et al. Association between pulse pressure and mortality in patients undergoing maintenance hemodialysis. JAMA. 2002;287(12):1548–55.PubMedGoogle Scholar
  105. 105.
    Covic A, Mardare N, Gusbeth-Tatomir P, et al. Increased arterial stiffness in children on haemodialysis. Nephrol Dial Transplant. 2006;21(3): 729–35.PubMedGoogle Scholar
  106. 106.
    Verrier-Jones K, Reid C, Evans J, Webb N, Gilbert R, Lewis M. Aspects of anaemia management in children with established renal failure. London: Royal College of Physicians and the Renal Association; 2006.Google Scholar
  107. 107.
    Amaral S, Hwang W, Fivush B, Neu A, Frankenfield D, Furth S. Association of mortality and hospitalization with achievement of adult hemoglobin targets in adolescents maintained on hemodialysis. J Am Soc Nephrol. 2006;17(10):2878–85.PubMedGoogle Scholar
  108. 108.
    Paoletti E, Specchia C, Di Maio G, et al. The worsening of left ventricular hypertrophy is the strongest predictor of sudden cardiac death in haemodialysis patients: a 10 year survey. Nephrol Dial Transplant. 2004;19(7):1829–34.PubMedGoogle Scholar
  109. 109.
    Qunibi WY. Cardiovascular calcification in nondialyzed patients with chronic kidney disease. Semin Dial. 2007;20(2):134–8.PubMedGoogle Scholar
  110. 110.
    Mitsnefes MM, Kimball TR, Kartal J, et al. Cardiac and vascular adaptation in pediatric patients with chronic kidney disease: role of calcium-phosphorus metabolism. J Am Soc Nephrol. 2005;16(9):2796–803.PubMedGoogle Scholar
  111. 111.
    Groothoff JW, Gruppen MP, Offringa M, et al. Increased arterial stiffness in young adults with end-stage renal disease since childhood. J Am Soc Nephrol. 2002;13(12):2953–61.PubMedGoogle Scholar
  112. 112.
    Civilibal M, Caliskan S, Adaletli I, et al. Coronary artery calcifications in children with end-stage renal disease. Pediatr Nephrol. 2006;21(10):1426–33.PubMedGoogle Scholar
  113. 113.
    Sanchez CP, Goodman WG, Ramirez JA, et al. Calcium-regulated parathyroid hormone secretion in adynamic renal osteodystrophy. Kidney Int. 1995;48(3):838–43.PubMedGoogle Scholar
  114. 114.
    Goodman WG, Goldin J, Kuizon BD, et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med. 2000;342(20):1478–83.PubMedGoogle Scholar
  115. 115.
    Block GA, Spiegel DM, Ehrlich J, et al. Effects of sevelamer and calcium on coronary artery calcification in patients new to hemodialysis. Kidney Int. 2005;68(4):1815–24.PubMedGoogle Scholar
  116. 116.
    Ketteler M, Bongartz P, Westenfeld R, et al. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet. 2003;361 (9360):827–33.PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Pediatric NephrologyGreat Ormond Street Hospital for ChildrenLondonUK
  2. 2.Department of NephrologyGreat Ormond Street Hospital for ChildrenLondonUK

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