Optic Disc Tumors



Although metastasis to the optic nerve is more common, it is important to be able to distinguish primary optic disc tumors from other types of disorders that mimic optic disc elevation with a different visual prognosis. Tumors of the sensory retina and medullary epithelium affecting the optic disc include retinoblastomas and medulloepitheliomas. Astrocytic hamartomas are glial tumors of the retina that can affect the optic disc. Vascular retinal tumors affecting the optic disc include capillary hemangiomas, cavernous hemangiomas, optic nerve hemangioblastomas, and racemose hemangiomas. Melanocytomas, choroidal melanomas, and combined hamartomas of the retina and retinal pigment epithelium comprise the melanocytic tumors of the optic disc.


Optic Nerve Retinal Pigment Epithelium Optic Disc Tuberous Sclerosis Complex Vitreous Hemorrhage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Shields JA, Augsburger JJ. Current approaches to the diagnosis and management of retinoblastoma. Surv Ophthalmol. 1981;25(6):347–72.PubMedGoogle Scholar
  2. 2.
    Shields JA. Diagnosis and management of intraocular tumors. St. Louis: Mosby; 1983.Google Scholar
  3. 3.
    Knudson Jr AG. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A. 1971;68(4):820–3.PubMedCentralPubMedGoogle Scholar
  4. 4.
    Ellsworth RM. The practical management of retinoblastoma. Trans Am Ophthalmol Soc. 1969;67:462–534.PubMedCentralPubMedGoogle Scholar
  5. 5.
    Kingston JE, Plowman PN, Hungerford JL. Ectopic intracranial retinoblastoma in childhood. Br J Ophthalmol. 1985;69(10):742–8.PubMedCentralPubMedGoogle Scholar
  6. 6.
    Bader JL, Meadows AT, Zimmerman LE, et al. Bilateral retinoblastoma with ectopic intracranial retinoblastoma: trilateral retinoblastoma. Cancer Genet Cytogenet. 1982;5(3):203–13.PubMedGoogle Scholar
  7. 7.
    Howard GM, Ellsworth RM. Differential diagnosis of retinoblastoma. A statistical survey of 500 children. II. Factors relating to the diagnosis of retinoblastoma. Am J Ophthalmol. 1965;60(4):618–21.PubMedGoogle Scholar
  8. 8.
    Shields JA, Leonard BC, Michelson JB, et al. B-scan ultrasonography in the diagnosis of atypical retinoblastomas. Can J Ophthalmol. 1976;11(1):42–51.PubMedGoogle Scholar
  9. 9.
    Hermsen VM. Echographic diagnosis. In: Lodi FC, editor. Retinoblastoma. New York: Churchill Livingstone; 1985. p. 62–71.Google Scholar
  10. 10.
    Merriam Jr GR. Retinoblastoma: analysis of 17 autopsies. Arch Ophthalmol. 1950;44(1):71–108.Google Scholar
  11. 11.
    Abramson DH, Ellsworth RM. Optic nerve involvement in retinoblastoma. Ophthalmology. 1989;96(2):217–22.PubMedGoogle Scholar
  12. 12.
    Shields CL, Shields JA. Retinoblastoma management: advances in enucleation, intravenous chemoreduction, and intra-arterial chemotherapy. Curr Opin Ophthalmol. 2010;21(3):203–12.PubMedGoogle Scholar
  13. 13.
    Karch SB, Urich H. Medulloepithelioma: definition of an entity. J Neuropathol Exp Neurol. 1972;31(1):27–53.PubMedGoogle Scholar
  14. 14.
    Green WR, Iliff WJ, Trotter RR. Malignant teratoid medulloepithelioma of the optic nerve. Arch Ophthalmol. 1974;91(6):451–4.PubMedGoogle Scholar
  15. 15.
    Grover WD, Harley RD. Early recognition of tuberous sclerosis by funduscopic examination. J Pediatr. 1969;75(6):991–5.PubMedGoogle Scholar
  16. 16.
    Robertson DM. Astrocytic hamartomas. Ann N Y Acad Sci. 1991;615(1):17–25.PubMedGoogle Scholar
  17. 17.
    Barksy D, Wolter JR. The retinal lesion of tuberous sclerosis: an angiogliomatous hamartoma? J Pediatr Ophthalmol. 1971;8:261.Google Scholar
  18. 18.
    Foos RY, Straatsma BR, Allen RA. Astrocytoma of the optic nerve head. Arch Ophthalmol. 1965;74:319–26.PubMedGoogle Scholar
  19. 19.
    Reeser FJ, Aaberg TM, van Horn D. Astrocytic hamartoma of the retina not associated with tuberous sclerosis. Am J Ophthalmol. 1978;86(5):688–98.PubMedGoogle Scholar
  20. 20.
    Lagos JC, Gomez MR. Tuberous sclerosis: reappraisal of a clinical entity. Mayo Clin Proc. 1967;42(1):26–49.PubMedGoogle Scholar
  21. 21.
    Cleasby GW, Fung WE, Shekter WB. Astrocytoma of the retina. Report of two cases. Am J Ophthalmol. 1967;64 suppl 3:633–7.PubMedGoogle Scholar
  22. 22.
    Font RL, Ferry AP. The phakomatoses. Int Ophthalmol Clin. 1972;12(1):1–50.PubMedGoogle Scholar
  23. 23.
    Turek M, Raistrick ER, Hart CD. Retinal tumours in neurofibromatosis. Can J Ophthalmol. 1977;12(1):68–70.PubMedGoogle Scholar
  24. 24.
    Darling TN, Skarulis MC, Steinberg SM, et al. Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1. Arch Dermatol. 1997;133(7):853–7.PubMedGoogle Scholar
  25. 25.
    Nickel WR, Reed WB. Tuberous sclerosis. Special reference to the microscopic alterations in the cutaneous hamartomas. Arch Dermatol. 1962;85:209–26.PubMedGoogle Scholar
  26. 26.
    Roach ES, Gomez MR, Northrup H. Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria. J Child Neurol. 1998;13(12):624–8.PubMedGoogle Scholar
  27. 27.
    McLean EB. Hamartoma of the retinal pigment epithelium. Am J Ophthalmol. 1976;82(2):227–31.PubMedGoogle Scholar
  28. 28.
    Macmichael IM. Von Hippel-Lindau’s disease of the optic disc. Trans Ophthalmol Soc U K. 1970;90:877–85.PubMedGoogle Scholar
  29. 29.
    Nicholson DH, Green WR, Kenyon KR. Light and electron microscopic study of early lesions in angiomatosis retinae. Am J Ophthalmol. 1976;82(2):193–204.PubMedGoogle Scholar
  30. 30.
    Pierro L, Guarisco L, Zaganelli E, et al. Capillary and cavernous hemangioma of the optic disc. Echographic and histological findings. Acta Ophthalmol Suppl. 1992;204:102–6.PubMedGoogle Scholar
  31. 31.
    Schindler RF, Sarin LK, MacDonald PR. Hemangiomas of the optic disc. Can J Ophthalmol. 1975;10(3):305–18.PubMedGoogle Scholar
  32. 32.
    Brown GC, Magargal LE, Schachat A, et al. Neovascular glaucoma. Etiologic considerations. Ophthalmology. 1984;91(4):315–20.PubMedGoogle Scholar
  33. 33.
    Augsburger JJ, Shields JA, Goldberg RE. Classification and management of hereditary retinal angiomas. Int Ophthalmol. 1981;4(1–2):93–106.PubMedGoogle Scholar
  34. 34.
    Hardwig P, Robertson DM. von Hippel-Lindau disease: a familial, often lethal, multi-system phakomatosis. Ophthalmology. 1984;91(3):263–70.PubMedGoogle Scholar
  35. 35.
    Carr RE, Noble KG. Retinal angiomatosis. Ophthalmology. 1980;87(9):956–9, 961.PubMedGoogle Scholar
  36. 36.
    Goldberg ME, Koenig S. Argon laser treatment of von Hippel-Lindau retinal angiomas. Arch Ophthalmol. 1974;92:121.PubMedGoogle Scholar
  37. 37.
    Annesley Jr WH, Leonard BC, Shields JA, et al. Fifteen year review of treated cases of retinal angiomatosis. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1977;83(83 Pt1):OP446–53.PubMedGoogle Scholar
  38. 38.
    Cardoso RD, Brockhurst RJ. Perforating diathermy coagulation for retinal angiomas. Arch Ophthalmol. 1976;94(10):1702–15.PubMedGoogle Scholar
  39. 39.
    Salazar EG, Lamiell JM. Early identification of retinal angiomas in a large kindred with von Hippel-Lindau disease. Am J Ophthalmol. 1980;89:540.PubMedGoogle Scholar
  40. 40.
    Lewis RA, Cohen MH, Wise GN. Cavernous haemangioma of the retina and optic disc. A report of three cases and a review of the literature. Br J Ophthalmol. 1975;59(8):422–34.PubMedCentralPubMedGoogle Scholar
  41. 41.
    Davies WS, Thumim M. Cavernous hemangioma of the optic disc and retina. Trans Am Acad Ophthalmol Otolaryngol. 1956;60(2):217–8.PubMedGoogle Scholar
  42. 42.
    Maruoka N, Yamakawa Y, Shimauchi M. Cavernous hemangioma of the optic nerve. Case report. J Neurosurg. 1988;69(2):292–4.PubMedGoogle Scholar
  43. 43.
    Castel JP, Delorge-Kerdiles C, Rivel J. Cavernous angioma of the optic chiasm. Neurochirurgie. 1989;35(4):252–6.PubMedGoogle Scholar
  44. 44.
    Kushner MS, Jampol LM, Haller JA. Cavernous hemangioma of the optic nerve. Retina. 1994;14(4):359–61.PubMedGoogle Scholar
  45. 45.
    Manschot WA. Juxtapapillary retinal angiomatosis. Arch Ophthalmol. 1968;80(6):775–6.PubMedGoogle Scholar
  46. 46.
    Kerr DJ, Scheithauer BW, Miller GM, et al. Hemangioblastoma of the optic nerve: case report. Neurosurgery. 1995;36(3):573–80.PubMedGoogle Scholar
  47. 47.
    In S, Miyagi J, Kojho N, et al. Intraorbital optic nerve hemangioblastoma with von Hippel-Lindau disease. J Neurosurg. 1982;56(3):426–9.PubMedGoogle Scholar
  48. 48.
    Ginzburg BM, Montanera WJ, Tyndel FJ, et al. Diagnosis of von Hippel-Lindau disease in a patient with blindness resulting from bilateral optic nerve hemangioblastomas. AJR Am J Roentgenol. 1992;159(2):403–5.PubMedGoogle Scholar
  49. 49.
    Nerad JA, Kersten RC, Anderson RL. Hemangioblastoma of the optic nerve. Report of a case and review of literature. Ophthalmology. 1988;95(3):398–402.PubMedGoogle Scholar
  50. 50.
    Hardwig P, Robertson DM. von Hippel-Lindau disease: a familial, often lethal, multisystem phakomatosis. Ophthalmology. 1984;91(3):263–70.PubMedGoogle Scholar
  51. 51.
    Seizinger BR, Rouleau GA, Ozelius LJ, et al. Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature. 1988;332(6161):268–9.PubMedGoogle Scholar
  52. 52.
    Krill AE. Hereditary retinal and choroidal diseases, vol. 2. Hagerstown: Harper and Row; 1997.Google Scholar
  53. 53.
    Lonser RR, Glenn GM, Walther M, Chew EY, Libutti SK, Linehan WM, et al. Von Hippel-Lindau disease. Lancet. 2003;361:2059–67.PubMedGoogle Scholar
  54. 54.
    Rosenberg RN, Prusiner SB, DiMauro S, et al. The molecular and genetic basis of neurologic and psychiatric disease. 3rd ed. Philadelphia, PA: Butterworth Heinemann; 2003.Google Scholar
  55. 55.
    Raila FA, Zimmerman J, Azordegan P, et al. Successful surgical removal of an asymptomatic optic nerve hemangioblastoma in von Hippel-Lindau disease. J Neuroimaging. 1997;7(1):48–50.PubMedGoogle Scholar
  56. 56.
    Wong WT, Chew EY. Ocular von Hippel-Lindau disease: clinical update and emerging treatments. Curr Opin Ophthalmol. 2008;19(3):213–7.PubMedCentralPubMedGoogle Scholar
  57. 57.
    Archer DB, Deutman A, Ernest JT, et al. Arteriovenous communications of the retina. Am J Ophthalmol. 1973;75(2):224–41.PubMedGoogle Scholar
  58. 58.
    Cameron ME, Greer CH. Congenital arteriovenous aneurysm of the retina. A post mortem report. Br J Ophthalmol. 1968;52(10):768–72.PubMedCentralPubMedGoogle Scholar
  59. 59.
    Theron J, Newton TH, Hoyt WF. Unilateral retinocephalic vascular malformations. Neuro-radiology. 1974;7(4):185–96.Google Scholar
  60. 60.
    Wyburn-Mason R. Arteriovenous aneurysm of the midbrain and retina, facial nevi and mental changes. Brain. 1943;66:163.Google Scholar
  61. 61.
    Kikuchi K, Kowada M, Sakamoto T, et al. Wyburn-Mason syndrome: report of a rare case with computed tomography and angiographic evaluations. J Comput Tomogr. 1988;12(2):111–5.PubMedGoogle Scholar
  62. 62.
    Ladow CS, McFall TA. Central hemangioma of the maxilla, with von Hippel’s disease: report of a case. J Oral Surg Anesth Hosp Dent Serv. 1964;22:252–9.PubMedGoogle Scholar
  63. 63.
    Sperner J, Schmauser I, Bittner R, et al. MR imaging findings in children with Sturge-Weber syndrome. Neuropediatrics. 1990;21(3):146–52.PubMedGoogle Scholar
  64. 64.
    Rundles Jr WZ, Falls HF. Congenital arteriovenous (racemose) aneurysm of the retina; report of 3 cases. AMA Arch Ophthalmol. 1951;46(4):408–18.PubMedGoogle Scholar
  65. 65.
    Cameron ME. Congenital arteriovenous aneurysm of the retina. Br J Ophthalmol. 1958;42(11):655–66.PubMedCentralPubMedGoogle Scholar
  66. 66.
    Destro M, D’Amico DJ, Gragoudas ES, et al. Retinal manifestations of neurofibromatosis. Diagnosis and management. Arch Ophthalmol. 1991;109(5):662–6.PubMedGoogle Scholar
  67. 67.
    Traboulsi EI. Neovascular glaucoma and ischemia. J Clin Neuro-Ophthalmol. 1986;6(2):126–7.Google Scholar
  68. 68.
    Joffe L, Shields JA, Osher RH, et al. Clinical and follow-up studies of melanocytomas of the optic disc. Ophthalmology. 1979;86(6):1067–83.PubMedGoogle Scholar
  69. 69.
    Shields JA, Demirci H, Mashayekhi A, et al. Melanocytoma of optic disc in 115 cases: the 2004 Samuel Johnson Memorial Lecture, part 1. Ophthalmology. 2004;111(9):1739–46.PubMedGoogle Scholar
  70. 70.
    Juarez CP, Tso MO. An ultrastructural study of melanocytomas (magnocellular nevi) of the optic disk and uvea. Am J Ophthalmol. 1980;90(1):48–62.PubMedGoogle Scholar
  71. 71.
    Mansour AM, Zimmerman L, La Piana FG, et al. Clinicopathological findings in a growing optic nerve melanocytoma. Br J Ophthalmol. 1989;73(6):410–5.PubMedCentralPubMedGoogle Scholar
  72. 72.
    Apple DJ, Craythorn JM, Reidy JJ, et al. Malignant transformation of an optic nerve melanocytoma. Can J Ophthalmol. 1984;19(7):320–5.PubMedGoogle Scholar
  73. 73.
    Croxatto JO, Ebner R, Crovetto L, et al. Angle closure glaucoma as initial manifestation of melanocytoma of the optic disc. Ophthalmology. 1983;90(7):830–4.PubMedGoogle Scholar
  74. 74.
    Shields CL, Demirci H, Karatza E, et al. Clinical survey of 1643 melanocytic and nonmelanocytic conjunctival tumors. Ophthalmology. 2004;111(9):1747–54.PubMedGoogle Scholar
  75. 75.
    Shields JA, Shields CL, Eagle Jr RC, et al. Malignant melanoma associated with melanocytoma of the optic disc. Ophthalmology. 1990;97(2):225–30.PubMedGoogle Scholar
  76. 76.
    Shields JA, Shields CL, Eagle Jr RC, et al. Central retinal vascular obstruction secondary to melanocytoma of the optic disc. Arch Ophthalmol. 2001;119(1):129–33.PubMedGoogle Scholar
  77. 77.
    Wiznia RA, Price J. Recovery of vision in association with a melanocytoma of the optic disk. Am J Ophthalmol. 1974;78(2):236–8.PubMedGoogle Scholar
  78. 78.
    Osher RH, Shields JA, Layman PR. Pupillary and visual field evaluation in patients with melanocytoma of the optic disc. Arch Ophthalmol. 1979;97(6):1096–9.PubMedGoogle Scholar
  79. 79.
    De Potter P, Shields CL, Shields JA, et al. Plaque radiotherapy for juxtapapillary choroidal melanoma. Visual acuity and survival outcome. Arch Ophthalmol. 1996;114(11):1357–65.PubMedGoogle Scholar
  80. 80.
    Gahankari MD, Jehangir R, Bhatti SS. Melanocytoma of the optic disc. J Postgrad Med. 1992;38(3):135–6.PubMedGoogle Scholar
  81. 81.
    Shields JA. Melanocytoma of the optic nerve head: a review. Int Ophthalmol. 1978;1(1):31–7.PubMedGoogle Scholar
  82. 82.
    Shields JA, Demirci H, Mashayekhi A, et al. Melanocytoma of the optic disk: a review. Surv Ophthalmol. 2006;51(2):93–104.PubMedGoogle Scholar
  83. 83.
    Sharma PM, Sangal K, Malik P, et al. Malignant transformation of optic disc melano-cytoma? A clinical dilemma at presentation with a review of the literature. Ophthalmologica. 2002;216(4):292–5.PubMedGoogle Scholar
  84. 84.
    Graham BJ, Duane TD. Ocular melanoma task force report. Am J Ophthalmol. 1980;90(5):728–33.PubMedGoogle Scholar
  85. 85.
    Margo CE, McLean IW. Malignant melanoma of the choroid and ciliary body in black patients. Arch Ophthalmol. 1984;102(1):77–9.PubMedGoogle Scholar
  86. 86.
    Haukin T, Teppo L, Saxen F. Cancer of the eye: a review of trends and differentials. World Health Stat Q. 1978;31:143–58.Google Scholar
  87. 87.
    Scotto J, Fraumeni Jr JF, Lee JA. Melanomas of the eye and other noncutaneous sites: epidemiologic aspects. J Natl Cancer Inst. 1976;56(3):489–91.PubMedGoogle Scholar
  88. 88.
    Ferry AP. Lesions mistaken for malignant melanoma of the posterior uvea: a clinicopathologic analysis of 100 cases with ophthalmoscopically visible lesions. Arch Ophthalmol. 1964;72:463–9.PubMedGoogle Scholar
  89. 89.
    Font RL, Spaulding AG, Zimmerman LE. Diffuse malignant melanoma: a clinicopathologic report of 54 cases. Trans Am Acad Ophthalmol Otolaryngol. 1968;72(6):877–95.PubMedGoogle Scholar
  90. 90.
    Shields JA. Lesions simulating malignant melanoma of the posterior uvea. Arch Ophthalmol. 1973;89(6):466–71.PubMedGoogle Scholar
  91. 91.
    Affeldt JC, Minckler DS, Azen SP, et al. Prognosis in uveal melanoma with extrascleral extension. Arch Ophthalmol. 1980;98(11):1975–9.PubMedGoogle Scholar
  92. 92.
    Shields CL, Shields JA. Recent developments in the management of choroidal melanoma. Curr Opin Ophthalmol. 2004;15(3):244–51.PubMedGoogle Scholar
  93. 93.
    Vogel MH, Zimmerman LE, Gass JD. Proliferation of the juxtapapillary retinal pigment epithelium simulating malignant melanoma. Doc Ophthalmol. 1969;26:461–81.PubMedGoogle Scholar
  94. 94.
    Cardell BS, Starbuck MS. Juxtapapillary hamartoma of retina. Br J Ophthalmol. 1961;45:672–7.PubMedCentralPubMedGoogle Scholar
  95. 95.
    Gass JD. An unusual hamartoma of the pigment epithelium and retina simulating choroidal melanoma and retinoblastoma. Trans Am Ophthalmol Soc. 1973;71:171–83. discussions 184–185.PubMedCentralPubMedGoogle Scholar
  96. 96.
    Schachat AP, Shields JA, Fine SL, et al. Combined hamartomas of the retina and retinal pigment epithelium. Ophthalmology. 1984;91(12):1609–15.PubMedGoogle Scholar
  97. 97.
    Rosenberg PR, Walsh JB. Retinal pigment epithelial hamartoma: unusual manifestations. Br J Ophthalmol. 1984;68(6):439–42.PubMedCentralPubMedGoogle Scholar
  98. 98.
    Kahn D, Goldberg MF, Jednock N. Combined retinal pigment epithelial hamartoma presenting as a vitreous hemorrhage. Retina. 1984;4(1):40–3.PubMedGoogle Scholar
  99. 99.
    Flood TP, Orth DH, Aaberg TM, et al. Macular hamartomas of the retinal pigment epithelium and retina. Retina. 1983;3(3):164–70.PubMedGoogle Scholar
  100. 100.
    Schachat AP, Glaser BM. Retinal hamartoma, acquired retinoschisis, and retinal hole. Am J Ophthalmol. 1985;99(5):604–5.PubMedGoogle Scholar
  101. 101.
    Kaye LD, Rothner AD, Beauchamp GR, et al. Ocular findings associated with neurofibromatosis type II. Ophthalmology. 1992;99(9):1424–9.PubMedGoogle Scholar
  102. 102.
    Palmer ML, Carney MD, Combs JL. Combined hamartomas of the retinal pigment epithelium and retina. Retina. 1990;10(1):33–6.PubMedGoogle Scholar
  103. 103.
    Sivalingam A, Augsburger J, Perilongo G, et al. Combined hamartoma of the retina and retinal pigment epithelium in a patient with neurofibromatosis type 2. J Pediatr Ophthalmol Strabismus. 1991;28(6):320–2.PubMedGoogle Scholar
  104. 104.
    Vianna RN, Pacheco DF, Vasconcelos MM, et al. Combined hamartoma of the retina and retinal pigment epithelium associated with neurofibromatosis type 1. Int Ophthalmol. 2001;24(2):63–6.PubMedGoogle Scholar
  105. 105.
    Fonseca RA, Dantas MA, Kaga T, et al. Combined hamartoma of the retina and retinal pigment epithelium associated with juvenile nasopharyngeal angiofibroma. Am J Ophthalmol. 2001;132(1):131–2.PubMedGoogle Scholar
  106. 106.
    Mason III JO. Visual improvement after pars plana vitrectomy and membrane peeling for vitreoretinal traction associated with combined hamartoma of the retina and retinal pigment epithelium. Retina. 2002;22(6):824–5.PubMedGoogle Scholar
  107. 107.
    Sappenfield DL, Gitter KA. Surgical intervention for combined hamartoma of the retina and retinal pigment epithelial hamartoma. Retina. 1990;10(2):119–24.PubMedGoogle Scholar
  108. 108.
    Stallman JB. Visual improvement after pars plana vitrectomy and membrane peeling for vitreoretinal traction associated with combined hamartoma of the retina and retinal pigment epithelium. Retina. 2002;22(1):101–4.PubMedGoogle Scholar
  109. 109.
    Inoue M, Noda K, Ishida S, et al. Successful treatment of subfoveal choroidal neovascularization associated with combined hamartoma of the retina and retinal pigment epithelium. Am J Ophthalmol. 2004;138(1):155–6.PubMedGoogle Scholar
  110. 110.
    McDonald HR, Abrams GW, Burke JM, et al. Clinicopathologic results of vitreous surgery for epiretinal membranes in patients with combined retinal and retinal pigment epithelial hamartomas. Am J Ophthalmol. 1985;100(6):806–13.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Neurology, Neuro-OphthalmologyUniversity of Nevada School of MedicineRenoUSA

Personalised recommendations