Role of Hypoxia-Inducible Transcription Factors in TAM Function

  • Nadine Rohwer
  • Thorsten Cramer


Tumour progression is characterized by massive cellular proliferation associated with alterations of the tumour microenvironment. Hence, the tumour microenvironment is considered to be of great importance for tumourigenesis and, as a consequence, might influence the response to antitumour therapy. The microenvironmental alterations comprise hypoxia, acidosis, nutrient starvation, as well as increased interstitial fluid pressure (Denko 2008; Milosevic et al. 2004; Pouyssegur et al. 2006; Vaupel et al. 1989) and are largely the result of a defective and/or inadequate tumour vasculature which develops during rapid tumour growth (Bertout et al. 2008; Brown and Giaccia 1998; Vaupel et al. 1989; Vaupel 2004). Hypoxia is present in virtually every solid tumour and probably represents the most persistent of the microenvironmental hallmarks that sway tumour progression.


Tumour Microenvironment Interstitial Fluid Pressure Macrophage Polarization Mutate Tumour Suppressor Gene Renal Cell Carcinoma Xenograft 
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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie and Molekulares KrebsforschungszentrumCharité – Universitätsmedizin BerlinBerlinGermany

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