Mapping PVS by Molecular Imaging with Contrast Agents
The primo vascular system (PVS) is now verified for its existence in the animal body. Some of its anatomical information and its role for a few diseases were also revealed. One of the important future tasks for better understanding the PVS may be its distribution (map) inside the body. Most studies already performed on the PVS visualization are limited to the vessels on the surface of various organs, and inside the lymph/blood vessels. Thorough mapping of PVS will be valuable because it may reveal the mode of the communication among the organs connected via this system. In addition, the changes in map of the PVS system in the course of disease progression may provide us with important information that can be utilized for better health management. Because the diameters of small PVS vessels are only in the range of tens of micrometers, for existing biomedical imaging modalities to be effective for imaging the system, external agents generating very high contrast combined with highly PVS-specific targeting agent will be required. In this chapter, a futuristic design of a single contrast agent guided by highly PVS-specific targeting molecule for MRI, X-ray/CT, optical, and TEM imaging is discussed.
KeywordsTransportation Polyethylene Glycol Polyethylene Glycol Flint
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