Cancer Genes, Tumor Suppressors, and Regulation of IGF1-R Gene Expression in Cancer

  • Haim WernerEmail author
  • Zohar Attias-Geva
  • Itay Bentov
  • Rive Sarfstein
  • Hagit Schayek
  • Doron Weinstein
  • Ilan Bruchim
Part of the Cancer Drug Discovery and Development book series (CDD&D)


The IGF1-R displays potent antiapoptotic, prosurvival activities and has an important role in cell cycle progression. In addition, activation of the IGF1-R signaling pathway is a crucial prerequisite for malignant transformation. Overexpression of the IGF1-R has been identified as a typical hallmark of many, but definitely not all, types of tumors. The level of expression of the IGF1-R gene is determined by the concerted action of positively acting and negatively acting transcription factors. Loss-of-function mutation of tumor suppressors, a characteristic feature of many human cancers, leads to IGF1-R expression, with ensuing activation of cell-surface receptors by circulating and/or locally produced IGF-1 and IGF-2.


Clear Cell Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Desmoplastic Small Round Cell Tumor Laron Syndrome Recurrent Chromosomal Translocation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Work in the laboratory of H.W. is supported by grants from the Israel Science Foundation, Israel Cancer Association, and Insulin-Dependent Diabetes Trust (IDDT, UK). I.B. wishes to thank the Israel Cancer Research Fund (ICRF, Montreal, Canada) for its generous support.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Haim Werner
    • 1
    Email author
  • Zohar Attias-Geva
    • 1
  • Itay Bentov
    • 1
  • Rive Sarfstein
    • 1
  • Hagit Schayek
    • 1
  • Doron Weinstein
    • 1
  • Ilan Bruchim
    • 1
  1. 1.Department of Human Molecular Genetics and Biochemistry, Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

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