The Role of Insulin-Like Growth Factor Signaling in Prostate Cancer Development and Progression

  • Bruce Montgomery
  • James Dean
  • Stephen PlymateEmail author
Part of the Cancer Drug Discovery and Development book series (CDD&D)


The insulin-like growth factor (IGF) pathway plays a critical role in the development and progression of multiple human malignancies, but the data are particularly compelling for a role in prostate cancer. IGF ligands and the insulin-like growth factor receptor-1 (IGF-IR) signal through multiple pathways, including the MAPK, PI-3K, and androgen receptor (AR). In this chapter, we review some of the published data on the mechanisms of IGF-IR signaling with a focus on IGF-IR and AR interaction and present new evidence that IGF-IR signaling may modulate AR localization and thus alter AR activity in prostate cancer cells. Multiple fully humanized antibodies targeting the IGF-IR are now in clinical trials, and this review is intended to reveal the mechanisms of potential therapeutic effects of these antibodies on prostate cancer. Targeting IGF and the IGF1-R holds significant promise for improving treatment for men with prostate cancer.


Prostate Cancer Androgen Receptor Prostate Cancer Progression Androgen Receptor Signaling Insulin Degrading Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Bruce Montgomery
    • 1
    • 2
  • James Dean
    • 1
  • Stephen Plymate
    • 3
    • 4
    Email author
  1. 1.Division of Oncology, Department of MedicineUniversity of Washington, Seattle Cancer Care AllianceSeattleUSA
  2. 2.VA Puget Sound Health Care SystemSeattleUSA
  3. 3.VA Puget Sound Health Care SystemSeattleUSA
  4. 4.Division of Geriatrics and Gerontology, Department of MedicineUniversity of Washington School of MedicineSeattleUSA

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