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IGF System and Breast Cancer

  • Marc A. Becker
  • Douglas YeeEmail author
Chapter
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

The insulin-like growth factor (IGF) pathway stimulates tumorigenesis and growth in breast cancer cells and can play a pivotal role in malignant progression. As a result, clinical efforts to target IGF action, namely via receptor-based strategies, are currently underway. While IGF-targeted therapies have shown activity in early clinical trials, benefits are seen in only a minority of patients suggesting that IGF pathway markers beyond the type I IGF receptor (IGF-1R) alone may improve patient stratification. This overview evaluates multiple facets of IGF pathway contribution in breast tumors and examines both current and future obstacles facing the clinical advancement of IGF-targeted therapeutics.

Keywords

Breast Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of PharmacologyUniversity of MinnesotaMinneapolisUSA
  2. 2.Masonic Cancer CenterUniversity of MinnesotaMinneapolisUSA
  3. 3.Department of MedicineUniversity of MinnesotaMinneapolisUSA

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